Protein Alignment Dap160 and eps15

DIOPT Version :10

• Sequence 1: NP_001246118.1
• Gene: Dap160 / 35378
• FlyBaseID: FBgn0023388
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_002663145.4
• Gene: eps15 / 795505
• ZFINID: ZDB-GENE-081104-264
• Length: 1039
• Species: Danio rerio
• Alignment Length: 1076
• Identity: 225/1076 - (20%)
• Similarity: 377/1076 - (35%)
• Gaps: 342/1076 - (31%)

  Fly     8 WAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFS 72
            |.|...|::|:...|.:|.|..|.:||.:.|...|.|:||..:||::|.|:|.|.||.::.:||:
Zfish   119 WVVKAEEKVKFDAIFDSLSPVGGMLTGDKVKPVLLNSKLPVDVLGRVWELSDIDRDGMLDKDEFA 183

  Fly    73 IACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAP 137
            :|..|:...|....||..||.:|:.      ||...                        |..:|
Zfish   184 VAMYLVYRALESEMVPMSLPAALIP------PSKRK------------------------PASSP 218

  Fly   138 PVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNAN 202
            ||            :|..|:|......:...|.|:..|:  .....:|.|..|.|.||..:|...
Zfish   219 PV------------MPLLPSPAQHKERNSAHSGSKTLPA--KATPSQWVVSPADKAKYDDLFAKT 269

  Fly   203 DRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLC-EKAMAGEKIP 266
            |....|.::|::.|.:.:::.||..|||:||.|.||...|:|..|:|.||::|. :|...|.:.|
Zfish   270 DTDMDGLVSGAEVRDIFLKTGLPSATLARIWELCDIGDVGKLTRDQFALALYLINQKLSKGIEPP 334

  Fly   267 VTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKE 331
            .||..|.:||                                               |.:..|:.
Zfish   335 QTLSPEMIPP-----------------------------------------------PDRLARQN 352

  Fly   332 NYVKGQA-------ELDR-RRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQL 388
            |.|..||       |||. ..:||:.|:.|...|::.|:|||..::..:.::   ..|||:::..
Zfish   353 NAVTLQAADFSAIKELDSLTNEIMDLQKEKSVVEQDIKDREETIRQRTSEVQ---DLQEEVQKGS 414

  Fly   389 QRQREIEMEKEEQRKRELEAKEAARKELEK-----QRQQEWEQARIAEMNAQKEREQERVLKQKA 448
            .....::.|::|.::: ||..:..::.||:     |:|...|...|..:..|...:::|:...:.
Zfish   415 DELGRLQAERQEVQEK-LERLDEQKRSLEEQLTLIQQQCSQESQLIQSLQVQHSEQEQRISDYEE 478

  Fly   449 HNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKL 513
            ..|:...||..|.|:.::|.:::...||.:..::..:....||.......:|:||...:|..|:|
Zfish   479 ELTRAREELLHLQEETRQLGEKVQSARAQLCPLEDAVKESHTQIVQEQERLSELKMEEREVTARL 543

  Fly   514 --------------------------------------------------------LQLTQERAK 522
                                                                    |::|:|...
Zfish   544 TWKILEEPVLVNGAAPSIEHPEPLQWPQPTAQPPETTKEDKVQDEEEQSSTDEPQELKVTEEEPG 608

  Fly   523 WEAKSKASGAALGGENAQQEQ---------LNAAFAH-KQLIINQIKDKVENISKEIESKKEDIN 577
            .||:..:|..      .|||.         .|:||:. ....:|..:...||.::|.|..:|..|
Zfish   609 SEAEEPSSSP------EQQESKPELYSYDLYNSAFSTISSTSVNWPQGNTENTTQEAEVDEEREN 667

  Fly   578 TND-VQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTG------SSSA 635
            |.: ...|..|||                   |...|.:...:.:|...|...:|      .|..
Zfish   668 TEERPATSTPKAE-------------------TVEPEKRETAQPDTEPPSNPPSGPGLDFFQSDP 713

  Fly   636 WEETGTTVTDPYAVASNDISALAAPAVDLGGP------------APEGFVKYQAVYEFNARNAEE 688
            :.::.....||:|            .||:..|            |.:.|.| |:...|.:|:
Zfish   714 FTDSDPFTEDPFA------------KVDISDPFGGDPFKGTDPFAADNFFK-QSSGSFPSRD--- 762

  Fly   689 ITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVAD 753
                       |. .:::|....|...      |:.:..| ....|.|     .|..:....:.|
Zfish   763 -----------PF-SSSDPFNTTGPKE------PDLFTSK-TTNAVTP-----DPFASSSGNLQD 803

  Fly   754 TYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGS 818
            |  |...:.....|.:|              |:.|:..|...|...:   |:.::|.      .|
Zfish   804 T--DPFGSKMDALADSD--------------PFSSSGTGPDPFGGSD---VVARDGP------AS 843

  Fly   819 RTGMFPSNYVQKADVGTASTAAAEPVES------LDQET------------TLNGNAAYTAA--- 862
            ....|       |..||...|.::|.::      ...||            ..|||..:.::
Zfish   844 ANDPF-------APGGTTVVANSDPDKTDPFAAVFGNETFGGGFADFSSLAKSNGNDPFDSSTNK 901

  Fly   863 ---PVEAQEQVYQPLPVQ--EPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSR 922
               ..:.|..|...||.:  .|:..|...||                  .:|....||.:||:.|
Zfish   902 NLFKEDTQSDVPPALPPKTGTPTRPPPPPPG------------------KRSNIHRSESSESFHR 948

  Fly   923 P---MSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQ 955
            .   .::.|:....:.||.|    |..|:..:|..|
Zfish   949 RGLFKAQGSAEFSSLPAKDS----VPDPFAPSSPHQ 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	33/92 (36%)
		EH	184..279	CDD:197477	36/95 (38%)
		SMC_prok_B	<368..>615	CDD:274008	57/318 (18%)
		SH3_Intersectin_1	674..728	CDD:212770	8/53 (15%)
		SH3_Intersectin_3	779..830	CDD:212772	8/50 (16%)
		SH3_Intersectin_4	941..998	CDD:212773	4/15 (27%)
		SH3_Intersectin_5	1025..1077	CDD:212774
		RRM_SF	<1125..1175	CDD:473069
eps15	XP_002663145.4	None