DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dap160 and Rbm28

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_598686.2 Gene:Rbm28 / 68272 MGIID:2655711 Length:750 Species:Mus musculus


Alignment Length:521 Identity:99/521 - (19%)
Similarity:169/521 - (32%) Gaps:161/521 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   241 DGRLNCDEFILAMFLCE--KAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRH 303
            ||::....|:....|.|  ||:.|             .|:::||.|..:|...|::...:.| :|
Mouse   150 DGKMRGFAFVQFKNLLEAGKALKG-------------ANMKEIKGRTVAVDWAVAKDKYKDA-QH 200

  Fly   304 ASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERE--------- 359
            ||..     ||..:....  |.::.:|...|:.|.|.....:  :|....:.||||         
Mouse   201 ASAP-----GVKKSSDRK--PKESGKKNCRVEEQVEDSDDEE--DDDSHDDEEERESTIASPVSV 256

  Fly   360 ----------RKEREEADKREKARLEAERKQQEE----LERQLQRQREIEMEKEEQRKREL---- 406
                      .:..||.|..|.:.||......:|    .|...:.|.:.::...|::||:|    
Mouse   257 HKRAVKRAAPEESIEEDDSYEDSDLEEGGSSYDEGTVDSESSAEDQEDEDVPVSEKKKRKLPSDV 321

  Fly   407 -------------EAKEAARKELEKQ--------------------------RQQEWEQARIAEM 432
                         :::|.|..|:.:|                          ..||..|..:|..
Mouse   322 TEGKTVFIRNLSFDSEEEALGEVLQQFGDLKYVRVVLHPDTEHSKGCAFAQFMTQEAAQKCLAAA 386

  Fly   433 NAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGM-----RTQR 492
            :.:.|..     ..|....||.|:|:...::..:|..:......|..|:....:|:     :...
Mouse   387 SLEAEGG-----GLKLDGRQLKVDLAVTRDEAAKLQTKKVKKPTGTRNLYLAREGLIRAGTKAAE 446

  Fly   493 DTSMSEMSQ------LK-ARIKEQN-------------------AKLLQLTQERAKWE------- 524
            ..|.::|::      || .::|.||                   .:|.:|..|..:.|       
Mouse   447 GVSAADMAKRERFELLKHQKLKNQNIFVSQTRLCLHNLPKAVDDKQLRKLLLEATRGEKGVRIKE 511

  Fly   525 ---------AKSKASGAALG---GENAQQEQLNAAFAH---KQLIINQIKDKVENISKEIESKKE 574
                     ...|..|.:||   .|..:.|....|..|   ...|....|..:...|.| :.:|.
Mouse   512 CRVMRDLKGVHGKMKGQSLGYAFAEFQKHEHALRALRHFNNNPEIFGSQKRPIVEFSLE-DRRKL 575

  Fly   575 DINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEET 639
            .:....:|.|..|.|...:.:|.:...||..           ..|.:..|.||....|.:..|:.
Mouse   576 KVKELRIQRSLQKMESKPVTSKPQKEQKEVG-----------KDKQQKVVQSATQDQSKAPGEQK 629

  Fly   640 G 640
            |
Mouse   630 G 630

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477
EH 18..83 CDD:238009
EH 184..279 CDD:197477 9/39 (23%)
EH 195..261 CDD:238009 7/21 (33%)
GBP_C <366..467 CDD:303769 25/147 (17%)
TACC 369..570 CDD:282818 51/300 (17%)
coiled coil 432..443 CDD:293879 1/10 (10%)
coiled coil 457..467 CDD:293879 1/9 (11%)
TBPIP <495..589 CDD:284512 27/141 (19%)
SH3_Intersectin_1 674..728 CDD:212770
SH3_Intersectin_3 779..830 CDD:212772
SH3_Intersectin_4 941..998 CDD:212773
SH3_Intersectin_5 1025..1077 CDD:212774
Rbm28NP_598686.2 RRM1_RBM28_like 5..81 CDD:240859
ELAV_HUD_SF 6..404 CDD:273741 55/281 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 84..110
RRM2_RBM28_like 115..190 CDD:240860 13/52 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..320 29/134 (22%)
RRM3_RBM28_like 325..407 CDD:240861 13/86 (15%)
RRM4_RBM28_like 477..571 CDD:240862 16/94 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..716 12/55 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0127
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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