| Sequence 1: | NP_001246118.1 | Gene: | Dap160 / 35378 | FlyBaseID: | FBgn0023388 | Length: | 1190 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_003015.2 | Gene: | ITSN1 / 6453 | HGNCID: | 6183 | Length: | 1721 | Species: | Homo sapiens |
| Alignment Length: | 1485 | Identity: | 441/1485 - (29%) |
|---|---|---|---|
| Similarity: | 659/1485 - (44%) | Gaps: | 469/1485 - (31%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 4 AVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68
Fly 69 NEFSIACKLINLKLRGMDVPKVLPPSL------LSSL----TGDVPSMTPRGSTSSLSPLD---- 119
Fly 120 PLKGIVPAVAPVVPVVA-PPVA--VATVISP------PGVSVPSGPTPPTSNPPSRHTSISERAP 175
Fly 176 SIESVN---QGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSD 237
Fly 238 IDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPG----SVSGVVSRPGSQ 298
Fly 299 PASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERKER 363
Fly 364 EEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQAR 428
Fly 429 IAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRD 493
Fly 494 TSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQ----------LNAAF 548
Fly 549 AHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELK-------------AELSALITK---- 596
Fly 597 -----------------------CEDLYKEYDVQRTSVLELKYNRKNETSV--SSAWDTGSSSAW 636
Fly 637 EETG-----------TTVTDPYAVASNDISALAAPAVDLGGP----APEG--FVKYQAVYEFNAR 684
Fly 685 NAEEITFVPGDIILVPLE-----QNAEPGWLAGEINGHTGWFPESYVEKLEVGEV-APVAAV--- 740
Fly 741 -----------EAPVDAQV------------ATVADTYNDNIN---------------TSSIPAA 767
Fly 768 S--------ADLTAAG-------------------------------------DV---------- 777
Fly 778 -------------------------------------------------------EYYIAAYPYE 787
Fly 788 SAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETT 852
Fly 853 LNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPA 917
Fly 918 ESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAK 982
Fly 983 GRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDI 1047
Fly 1048 ISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACS------------RRSKG-IQR 1099
Fly 1100 L---------------------------------------WQQWRGCDIDQAAQHGDASNNKLRG 1125
Fly 1126 IIQAVHITKRRDGQLMGC---------------AYVRFECNELLAKSMLQENGNQ 1165 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Dap160 | NP_001246118.1 | EH | 7..101 | CDD:197477 | 51/103 (50%) |
| EH | 18..83 | CDD:238009 | 37/64 (58%) | ||
| EH | 184..279 | CDD:197477 | 53/94 (56%) | ||
| EH | 195..261 | CDD:238009 | 40/65 (62%) | ||
| GBP_C | <366..467 | CDD:303769 | 47/100 (47%) | ||
| TACC | 369..570 | CDD:282818 | 69/210 (33%) | ||
| coiled coil | 432..443 | CDD:293879 | 4/10 (40%) | ||
| coiled coil | 457..467 | CDD:293879 | 4/9 (44%) | ||
| TBPIP | <495..589 | CDD:284512 | 22/116 (19%) | ||
| SH3_Intersectin_1 | 674..728 | CDD:212770 | 29/58 (50%) | ||
| SH3_Intersectin_3 | 779..830 | CDD:212772 | 29/50 (58%) | ||
| SH3_Intersectin_4 | 941..998 | CDD:212773 | 41/56 (73%) | ||
| SH3_Intersectin_5 | 1025..1077 | CDD:212774 | 32/51 (63%) | ||
| ITSN1 | NP_003015.2 | EH | 14..108 | CDD:197477 | 49/93 (53%) |
| EH | 26..90 | CDD:238009 | 37/63 (59%) | ||
| EH | 214..309 | CDD:197477 | 53/94 (56%) | ||
| EH | 225..291 | CDD:238009 | 40/65 (62%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 322..348 | 3/25 (12%) | |||
| KLERQ | 326..702 | 109/395 (28%) | |||
| GBP_C | <331..414 | CDD:303769 | 31/91 (34%) | ||
| COG1340 | 372..686 | CDD:224259 | 93/324 (29%) | ||
| coiled coil | 383..394 | CDD:293879 | 3/10 (30%) | ||
| coiled coil | 403..414 | CDD:293879 | 7/10 (70%) | ||
| AAA_23 | <509..636 | CDD:290211 | 27/137 (20%) | ||
| GBP_C | <616..686 | CDD:303769 | 9/69 (13%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 650..701 | 10/50 (20%) | |||
| SH3_Intersectin1_1 | 744..803 | CDD:212920 | 29/58 (50%) | ||
| INTAP | 803..917 | CDD:293223 | 18/113 (16%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 836..868 | 4/31 (13%) | |||
| SH3_Intersectin1_2 | 917..968 | CDD:212922 | 2/50 (4%) | ||
| SH3_Intersectin1_3 | 1006..1057 | CDD:212924 | 29/50 (58%) | ||
| SH3_Intersectin1_4 | 1074..1138 | CDD:212926 | 45/63 (71%) | ||
| Required for interaction with FCHSD2. /evidence=ECO:0000269|PubMed:29887380 | 1074..1138 | 45/63 (71%) | |||
| Bipartite nuclear localization signal, in isoform 2. /evidence=ECO:0000269|PubMed:29599122 | 1104..1127 | 16/22 (73%) | |||
| SH3_Intersectin1_5 | 1158..1211 | CDD:212928 | 32/55 (58%) | ||
| RhoGEF | 1242..1422 | CDD:279015 | 14/123 (11%) | ||
| PH_ITSN | 1448..1579 | CDD:270084 | |||
| PH | 1465..1571 | CDD:278594 | |||
| C2_Intersectin | 1582..1716 | CDD:176021 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C165154119 | |
| Domainoid | 1 | 1.000 | 171 | 1.000 | Domainoid score | I3751 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1029 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H2277 | |
| Inparanoid | 1 | 1.050 | 567 | 1.000 | Inparanoid score | I1078 |
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG45992 | |
| OrthoDB | 1 | 1.010 | - | - | D349276at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0002286 | |
| OrthoInspector | 1 | 1.000 | - | - | otm41416 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_103215 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR11216 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2056 |
| SonicParanoid | 1 | 1.000 | - | - | X1514 | |
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 1 | 0.960 | - | - | ||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 16 | 15.800 | |||||