DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and pan1

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001342822.1	Gene:	pan1 / 5802955	PomBaseID:	SPAC25G10.09c	Length:	1794	Species:	Schizosaccharomyces pombe

Alignment Length:	1012	Identity:	214/1012 - (21%)
Similarity:	355/1012 - (35%)	Gaps:	255/1012 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 KLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVI 145
            ::.||..|      :....||..|.|..|   :.:.|..|  |:...:||....:.|.....|.:
pombe   693 QMPGMQQP------MAPQRTGMQPMMPQR---TGMQPQMP--GMQQPMAPQRTGMQPMAPQRTGM 746

  Fly   146 SPP---GVSVP---SGPTPPTSNPPSR----HTSISERAPSIESVNQG----------------- 183
            .|.   |..:|   .|..|..:..|.:    :|.:| ..|.||::.|.
pombe   747 QPQMTGGPMLPQRTGGMAPQPTGMPGQWGFINTPLS-NLPGIEALGQQMMPNAPSGGLNNTFQQK 810

  Fly   184 ---EWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLN 245
               .||:...:||.|.|:|:|.|:.|.|.|.|:....:..||||.:..|..||.|.|....|.|:
pombe   811 KDIPWAISKEEKRIYDQIFDAWDKERKGTLGGNAVLEIFGQSKLTRTELEHIWNLCDHGDKGSLD 875

  Fly   246 CDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQS 310
            .|||.:|:.|..:.:.|.::|..||.|.:||:.|........|..::....|
pombe   876 RDEFAVALHLIYRKLNGNEVPAVLPPELIPPSTRNFTESLNQVKNLIKNDTS------------- 927

  Fly   311 GVGVVDADPTAGLPGQNKRKEN--YVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKAR 373
                 :..| .|...|:|.|:|  |                ....|..|::.......|....|.
pombe   928 -----NRKP-FGAENQSKLKKNSFY----------------DNPSETTEKDATLYRHNDSDASAY 970

  Fly   374 LEAERK---QQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQ 435
            :.:.|:   ::|::|.......:|:.|....:|| :..|......||.:        ::|...|.
pombe   971 VSSARRRDFKEEKIESAPPIINDIDSEIASLKKR-IHEKSLVVNALEDK--------KLAATPAN 1026

  Fly   436 KEREQERVLKQKAHNTQLN--------VELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQ- 491
            ..:....:.:.|:...::|        .|::::|.:::|||.|:....:.:..|...|..:..:
pombe  1027 DVQNDSLIYRIKSVQDEINRLSTSNKSPEVASMNVRLEELSTRVSKMLSDINEVDHTIASLSLKL 1091

  Fly   492 ---RDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQL 553
               .||..|.........:|:|..:.....|..|.:.:|||:
pombe  1092 FQAEDTKNSYDQTSPEATQERNRTISSKLAEMEKQKNESKAA----------------------- 1133

  Fly   554 IINQIKDKVENISKEIESKKEDINTN-DVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYN 617
             :.|:|:.|.||...|.:|......| |..:|:...:.|  :|:   :.||..|...:..: ..|
pombe  1134 -LEQMKNYVTNIENNIRAKLLPSAANDDAWLSQNVVDES--VTR---VVKELPVPAPAAPQ-TLN 1191

  Fly   618 RKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFN 682
            ..:.::|..:....|::...|...|...|  .||:::...||.            :|.:|....|
pombe  1192 PPSVSTVQQSKPIESNTHTPEVKATSESP--SASSNLEDRAAR------------IKAEAQRRMN 1242

  Fly   683 ARNA-------EEITFVPGDI-------ILVPLEQNAEPGWLAGEINGHTGWFPESY-------- 725
            .|.|       ::.|..|..:       :..|..|..:||..|..::.:......|.
pombe  1243 ERLAALGIKPRQKGTPSPAPVNSATSTPVAAPTAQQIQPGKQASAVSSNVPAVSASISTPPAVVP 1307

  Fly   726 -VEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAA---------------------- 767
             |:..:..:..|.|||:.|         .|.:.:.||:.||..
pombe  1308 TVQHPQPTKQIPTAAVKDP---------STTSTSFNTAPIPQQAPLENQFSKMSLEPPVRPAVPT 1363

  Fly   768 --------SADLTAAGDVEYYIAAYPYESA--------EEGDL--SFSAGEMVMVIKKEGEWWTG 814
                    |:::.|.......:.|.|..:|        |..|.  |.|:|..|..|:.|    |.
pombe  1364 SPKPQIPDSSNVHAPPPPVQPMNAMPSHNAVNARPSAPERRDSFGSVSSGSNVSSIEDE----TS 1424

  Fly   815 TIGSRTGM-----FPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTA----APVE----A 866
            |:..:...     .|||:..:. |..|...|..||:........|..|..:|    |||.    |
pombe  1425 TMPLKASQPTNPGAPSNHAPQV-VPPAPMHAVAPVQPKAPGMVTNAPAPSSAPAPPAPVSQLPPA 1488

  Fly   867 QEQVYQPLPVQEPS--EQPISS-----------PGVGAEEAHEDLDTEVSQINTQSKTQSSEPAE 918
            ...|  |:|...||  :||.||           |...:..||.......:..:..:...||.||:
pombe  1489 VPNV--PVPSMIPSVAQQPPSSVAPATAPSSTLPPSQSSFAHVPSPAPPAPQHPSAAALSSAPAD 1551

  Fly   919 SYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQ 955
            : |.| .|:|...|....::.:....|||.....|.|
pombe  1552 N-SMP-HRSSPYAPQEPVQKPQAINNIAPATNLGTSQ 1586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	3/19 (16%)
		EH	18..83	CDD:238009	0/1 (0%)
		EH	184..279	CDD:197477	36/94 (38%)
		EH	195..261	CDD:238009	25/65 (38%)
		GBP_C	<366..467	CDD:303769	18/111 (16%)
		TACC	369..570	CDD:282818	38/215 (18%)
		coiled coil	432..443	CDD:293879	1/10 (10%)
		coiled coil	457..467	CDD:293879	1/9 (11%)
		TBPIP	<495..589	CDD:284512	18/94 (19%)
		SH3_Intersectin_1	674..728	CDD:212770	14/76 (18%)
		SH3_Intersectin_3	779..830	CDD:212772	16/65 (25%)
		SH3_Intersectin_4	941..998	CDD:212773	5/15 (33%)
		SH3_Intersectin_5	1025..1077	CDD:212774
pan1	NP_001342822.1	DUF1720	177..262	CDD:311924
		EH	276..368	CDD:197477
		DUF1720	422..508	CDD:311924
		Med15	473..>796	CDD:312941	27/114 (24%)
		EH	814..909	CDD:197477	36/94 (38%)
		SMC_N	<976..>1150	CDD:330553	37/206 (18%)
		Atrophin-1	<1180..1637	CDD:331285	91/440 (21%)
		WH2	1746..1772	CDD:308040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010