DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and itsn2a

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_021324162.1	Gene:	itsn2a / 566412	ZFINID:	ZDB-GENE-041014-84	Length:	1666	Species:	Danio rerio

Alignment Length:	1465	Identity:	418/1465 - (28%)
Similarity:	639/1465 - (43%)	Gaps:	432/1465 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGK 65
            ||.....||:||.||.|:.:||.:|.|..|:::|.||:.|||||.||..:|..||||||...|||
Zfish     1 MNGGFSIWAITPEERGKHDKQFDSLAPTLGYLSGDQARKFFLQSGLPTSVLADIWALADIGKDGK 65

  Fly    66 MNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTP-----RGSTSSLSPLDPLKGIV 125
            |:..|||||.|||.|:|:|..:|..||..:..:.|   |.||.     .||..:||.:..:..:.
Zfish    66 MDRLEFSIAMKLIKLQLQGQPLPSSLPIIMKQTPT---PVMTSSSRFGMGSMPNLSAMSVMPILT 127

  Fly   126 PAVAPVVPVVAPPVAVATVIS------PPGVSVPS---------GPTP----------------- 158
            |  .|..||:||.|.|.|:||      |..:|||:         .|||
Zfish   128 P--IPTCPVMAPLVPVPTLISGPLPQMPNSISVPALPNGNATLLTPTPAFPVSSGLTKSHSLLDL 190

  Fly   159 -PTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQS 222
             .:|:..|..||::..:|...|   .:|||..:.:.||.|:||:.|:..||||:|.|.|..|..|
Zfish   191 GSSSSNSSSTTSLASNSPKTSS---SDWAVPQSSRLKYRQLFNSLDKLMSGYLSGPQVRNALTAS 252

  Fly   223 KLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGS 287
            .|.|..||.||.|:|:|.||:|..:||||||.|.|.|..|..:|:|||.:.|||:||..|| ...
Zfish   253 NLTQTQLATIWFLADVDRDGQLRAEEFILAMHLVEMAKTGRPLPLTLPPDLVPPSLRTTKS-CDL 316

  Fly   288 VSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQ- 351
            ::|.|....::.........::|.|...|           |.:||:.:|.|||::||..:::||
Zfish   317 LNGPVPLISTELIEPELPQKNKSNVSYED-----------KLRENFQRGNAELEKRRLALQEQQR 370

  Fly   352 ----------RKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKREL 406
                      |:|.|:|::|||||.::||:...|.|.::|.|.||:::||||:|.::||:|.:||
Zfish   371 REEERRREEERREEEKRQQKEREERERREREAREMEIRRQREEERRMERQRELERQREEERLKEL 435

  Fly   407 EAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRI 471
            |.:|    |.|:||::|||:::..|:..|||:||..:.:.|.....|.:||..:..|.|::|.::
Zfish   436 ERRE----EAERQRRREWEKSKRVELQTQKEKEQNDIQRLKDRKRSLEIELEAVGNKHKQISSQL 496

  Fly   472 CDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWE------------ 524
            .|.::........::.:..:||..:::::.|:.:..|...:|.||..|:.:..
Zfish   497 RDAKSKRQGQWAELELINQRRDVCITDINSLQLQFDEMQRQLNQLGPEKQRLADRLVHFTQNISS 561

  Fly   525 -----------------AKSKASGAALGGEN----AQQEQLNAAF-------------------- 548
                             .|.|.....|..|.    :|.||.|...
Zfish   562 PLINDVKQSVCEKDRSCRKLKEQLDVLERETTAKLSQMEQYNKEIKFVEMDDCVLQGLLSLLGCL 626

  Fly   549 --------------AHKQLIINQIK----DKVENISK------EIESKKEDINTNDVQMSELK-- 587
                          :.:|.::.|::    ||::.:.:      |.:.|||:......|:.:.:
Zfish   627 TNLFLLIKELRQKQSQQQDVLEQLRRVRSDKLKELQRHRKEEEERKRKKEEEAARQAQLEQERLE 691

  Fly   588 ---AELSALITKCEDLYKEYDVQRTSVLEL----------------KYNRKNETSVSSAWDTGSS 633
               ||....:.:..:.....:.||.::..|                :...:||..|    .|.||
Zfish   692 QEEAERQRKLAQEREAKLREEQQRQALARLLEAQEQARAKEEKRRAEEKERNELDV----HTQSS 752

  Fly   634 SAWEETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIIL 698
            ..:..|...:..|..:.....|:|..               |:|:|.|.|||::|:|......|.
Zfish   753 LPFNSTENNILQPVVIPEVTCSSLTT---------------YRALYPFTARNSDELTLEADCFIQ 802

  Fly   699 VPLEQNAEPGWLAGEINGHTGWFPESYVEK-----------LEVGEVAPVA--------AVEAPV 744
            |......|.|||.|..:|:.|||||||.|:           .|....||.|        .:|.|.
Zfish   803 VDESTVRETGWLYGSYSGNRGWFPESYAERCSKDSQTQPTAAETESTAPSANYPGIPRVDIEGPT 867

  Fly   745 DAQVATVADTYN---------------------DNI----------------------------- 759
            ........:|.:                     |:|
Zfish   868 PTHTPVSTNTQHSQAVALCEWSAKTDSHLGFCKDDIITVLEKQENWWYGELKEKRGWFPCSHVSV 932

  Fly   760 ----NTSSIPAASA----DLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTI 816
                ||.|.|..|:    :::.:|.::.|:|.|.|||.|.|||:|||.::|:|.:||||||.|.|
Zfish   933 VTTNNTQSEPLYSSVEEIEVSDSGLLDEYVALYTYESPESGDLTFSAEDVVLVTEKEGEWWRGCI 997

  Fly   817 GSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQPLPVQEPSE 881
            |.:||:||||||:..:..|||:|.                                      ||:
Zfish   998 GDQTGLFPSNYVKPKEPDTASSAV--------------------------------------PSK 1024

  Fly   882 QPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIA 946
            :|                                                        |||||..
Zfish  1025 KP--------------------------------------------------------EIAQVTT 1033

  Fly   947 PYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPV 1011
            ...||:.||||||.||||::..|..:.||.|||||:|::|:.|||.::.|::|:.  |||:.||
Zfish  1034 VSPATTPEQLSLTPGQLIVVLHKNSNSWWLGELQARGKKRKKGWFQSSNVRLLEA--NSGKITP- 1095

  Fly  1012 SGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVG 1076
                   ..|.|.:|||:|.|||.|.||:||.|..:|:||.:|.|:||:||:.|::||||:|||.
Zfish  1096 -------APQPLCQVIAMYDYKAANKDEMSFQKGQLITVLNKDNPDWWKGEVAGVTGLFPTNYVK 1153

  Fly  1077 PFVTSEIKPDPGACS------------RRSKG-IQRLWQQWRGC--DIDQA--------AQHGDA 1118
              :|:|..|....|:            |:.:| |..|.|.....  |::.|        |:.|..
Zfish  1154 --MTTECDPSQQWCADLLSLDSMCTEERKRQGYIHELIQTEESYLEDLELAVEVFYKPMAESGRL 1216

  Fly  1119 SNNKLRGI--------------IQAVHITKRRDGQLMGC---------------AYVRFECNELL 1154
            :..::..|              ::|:.:.|:..|:.|..               ||:||...:|.
Zfish  1217 TEAEISMIFVNWRELIMCSTKLLKALRVRKKTAGERMPVQVVGDILSSELSHMQAYIRFCSCQLN 1281

  Fly  1155 AKSMLQENGNQLVGKAVVVDWQPELPKKRFRQWRC 1189
            |.::||:..::      .:|::..| ||....:||
Zfish  1282 AAALLQQKTDK------SLDFKLFL-KKIASNYRC 1309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	47/93 (51%)
		EH	18..83	CDD:238009	35/64 (55%)
		EH	184..279	CDD:197477	47/94 (50%)
		EH	195..261	CDD:238009	35/65 (54%)
		GBP_C	<366..467	CDD:303769	39/100 (39%)
		TACC	369..570	CDD:282818	62/277 (22%)
		coiled coil	432..443	CDD:293879	5/10 (50%)
		coiled coil	457..467	CDD:293879	3/9 (33%)
		TBPIP	<495..589	CDD:284512	23/175 (13%)
		SH3_Intersectin_1	674..728	CDD:212770	24/53 (45%)
		SH3_Intersectin_3	779..830	CDD:212772	32/50 (64%)
		SH3_Intersectin_4	941..998	CDD:212773	30/56 (54%)
		SH3_Intersectin_5	1025..1077	CDD:212774	30/51 (59%)
itsn2a	XP_021324162.1	EH	7..92	CDD:197477	45/84 (54%)
		EH	214..293	CDD:197477	39/78 (50%)
		SMC_N	453..>727	CDD:330553	44/273 (16%)
		SH3_Intersectin2_1	776..832	CDD:212921	25/70 (36%)
		SH3	881..932	CDD:327375	2/50 (4%)
		SH3_Intersectin_3	960..1011	CDD:212772	32/50 (64%)
		SH3_Intersectin2_4	1028..1086	CDD:212927	30/57 (53%)
		SH3	1101..1154	CDD:327375	30/54 (56%)
		RhoGEF	1181..1364	CDD:238091	27/136 (20%)
		PH_13	1383..1523	CDD:318790
		C2_Intersectin	1524..1658	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589268
Domainoid	1	1.000	180	1.000	Domainoid score	I3454
eggNOG	1	0.900	-	-		E1_KOG1029
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	519	1.000	Inparanoid score	I1232
OMA	1	1.010	-	-		QHG45992
OrthoDB	1	1.010	-	-		D349276at33208
OrthoFinder	1	1.000	-	-		FOG0002286
OrthoInspector	1	1.000	-	-		otm25765
orthoMCL	1	0.900	-	-		OOG6_103215
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X1514
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800