DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dap160 and pacsin1a

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_001315286.1 Gene:pacsin1a / 553559 ZFINID:ZDB-GENE-050522-155 Length:438 Species:Danio rerio


Alignment Length:476 Identity:91/476 - (19%)
Similarity:175/476 - (36%) Gaps:138/476 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   332 NYVKGQAELDRRRKIMED-----QQRKEREERERKEREEADKREKARLE---------------- 375
            ||.:....:|...::..|     |:|.:.|:....:..|..||.:..:|                
Zfish    23 NYKRAVKRIDDGHRLCNDLMNCLQERAKIEKSYSAQLTEWSKRWRQLIEKGPQYGSVERAWIAMM 87

  Fly   376 AERKQQEELERQLQR---QREIEMEKEEQR---KREL-----EAKEAARKELEKQRQQEWEQARI 429
            .|..:..||.::::.   ..::|..|..|:   .|::     |.|||  :|..|:.|:.|.: ::
Zfish    88 TEADKVSELHQEVKNGLMNEDVEKVKNWQKDSYHRQMMGGFKETKEA--EEGFKKAQKPWAK-KL 149

  Fly   430 AEMNAQKE------REQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGM 488
            .||...|:      :|::....::|..:....:...|:||.::..|   |.:......:..:|.:
Zfish   150 KEMETAKKTYHMACKEEKLAASREADASVTPDQQKKLHEKTEKCKQ---DVQKAKEKYEKSLDEL 211

  Fly   489 RTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQL 553
            ...|...|..|.|:..:.::...|.|...                       :|.|.....|..|
Zfish   212 SKCRPPYMESMEQVFDQCQQHEVKRLTFL-----------------------KEVLLDIKRHLNL 253

  Fly   554 IINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDL-----------------Y 601
            ..||   ....:.:|.|......||.                  |||                 :
Zfish   254 TENQ---NYAAVYREFERTILAANTQ------------------EDLKWFSNNHGPGMHMNWPQF 297

  Fly   602 KEYDVQRTSVLELKYNRK---------NETSVSSAWDTGSSSAWEETGTTVTD------PYAVAS 651
            :||:.:.|:.:..:..:|         |........|.||.|::::..|..|:      |...:.
Zfish   298 EEYNPEATNAVAKREKKKPDGVAPATPNTEHAGQPGDRGSVSSYDKNQTYSTEWSDDEQPAGYSG 362

  Fly   652 NDISALAAPAVDLGG-------PAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGW 709
            |:.:         ||       .|..|.|:.:|:|:::.:..:|::|..|| .|..:|:..:.||
Zfish   363 NETN---------GGANSFEEDTASRGGVRVRALYDYDGQEQDELSFKAGD-ELTKIEEEDDQGW 417

  Fly   710 LAGEI-NGHTGWFPESYVEKL 729
            ..|.: :|.:|.:|.:|||::
Zfish   418 CRGRLDSGRSGLYPANYVEEI 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477
EH 18..83 CDD:238009
EH 184..279 CDD:197477
EH 195..261 CDD:238009
GBP_C <366..467 CDD:303769 26/133 (20%)
TACC 369..570 CDD:282818 41/233 (18%)
coiled coil 432..443 CDD:293879 3/16 (19%)
coiled coil 457..467 CDD:293879 3/9 (33%)
TBPIP <495..589 CDD:284512 15/93 (16%)
SH3_Intersectin_1 674..728 CDD:212770 16/54 (30%)
SH3_Intersectin_3 779..830 CDD:212772
SH3_Intersectin_4 941..998 CDD:212773
SH3_Intersectin_5 1025..1077 CDD:212774
pacsin1aNP_001315286.1 BAR 18..270 CDD:299863 51/278 (18%)
SH3_PACSIN1-2 382..436 CDD:212931 16/54 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.