DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and ITSN2

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_006268.2	Gene:	ITSN2 / 50618	HGNCID:	6184	Length:	1697	Species:	Homo sapiens

Alignment Length:	1455	Identity:	438/1455 - (30%)
Similarity:	660/1455 - (45%)	Gaps:	432/1455 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGK 65
            ||...:.||:|..||.|:..||..|:|..|::||.||:.|||||.||..:|.:||||:|.:.|||
Human     9 MNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGK 73

  Fly    66 MNINEFSIACKLINLKLRGMDVPKVLPP---------SLLSSL--TGDVPSMT------PRGSTS 113
            |:..|||||.|||.|||:|..:|.||||         .|:|:.  .|.:|:::      |....:
Human    74 MDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAAPIT 138

  Fly   114 SLSP------LDPLKGIVPAVAPVVPVVAP---PVAVATVISPPGVSVPSGPTP----------- 158
            |||.      |.||  ::|  .|:||.|:.   |...|::|.|..:...|...|
Human   139 SLSSATSGTNLPPL--MMP--TPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGG 199

  Fly   159 ---------------PTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSG 208
                           .:|:..|...|:|..:|   .....||||....:.||.|.||..|::.||
Human   200 FGGASIQKAQSLIDLGSSSSTSSTASLSGNSP---KTGTSEWAVPQPTRLKYRQKFNTLDKSMSG 261

  Fly   209 YLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEW 273
            ||:|.|||..|:||.|.|..||.||||:|:||||:|..:||||||.|.:.|.||:.:|:|||.|.
Human   262 YLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPEL 326

  Fly   274 VPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLP--GQNKRKENYVKG 336
            |||:.|..| :..|::|.:  |..|.              :.:.:|...||  .::|||.||.:|
Human   327 VPPSFRGGK-QIDSINGTL--PSYQK--------------MQEEEPQKKLPVTFEDKRKANYERG 374

  Fly   337 QAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQ 401
            ..||::||:.:.:||::|.|.:.:||:||.:::::...|.|.|:|.|||::|::|||:|.::||:
Human   375 NMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEE 439

  Fly   402 RKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKE 466
            |::::|.:|||::|||:||:.|||:.|..|:..||.||||.:::..:....|::||..||.|.::
Human   440 RRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQ 504

  Fly   467 LSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLL------QLTQERAK--W 523
            :|.|:.|.|......||.::.:..|.|..:.|:.||:..::|...||:      ||..||.|  .
Human   505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569

  Fly   524 EAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQM----- 583
            .:.:..||.:|         |:.....|:.:..::|::::.:.||..||..::::.:.|:
Human   570 FSNTPDSGVSL---------LHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNM 625

  Fly   584 --SELKAELSALITKC--------EDLYKEYDVQRTSV------------------LELKYNRKN 620
              |.|:..||.|  .|        ::|.:.|:.|:.::                  |||...:|.
Human   626 DDSVLQCLLSLL--SCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 688

  Fly   621 ETSVSSAWDTGSSSAW-----------------EETGTTVTDPYAVAS----NDISALAAPAVDL 664
            |...:.....|..:.|                 |:|...:.:....|.    .|...|.|.  :.
Human   689 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAE--EK 751

  Fly   665 GGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKL 729
            ........|.|:|:|.|.|||.:|::|..||||.|..:...|||||.|...|:.||||.:||||:
Human   752 KRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKM 816

  Fly   730 EVGE----VAPVAAVEAPV--------------DAQVATVADTYNDN-----INTS--------- 762
            ...|    |:|..|:..|.              ..|.|:|.|..|.:     :|||
Human   817 PSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881

  Fly   763 -SIPAASADLTAAGDV------------------------------------------------- 777
             ..|.:.:.:...|.|
Human   882 TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWF 946

  Fly   778 -------------------------------------EYYIAAYPYESAEEGDLSFSAGEMVMVI 805
                                                 |.|||.|||.|.|.|||:|:.||.::|.
Human   947 PKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVT 1011

  Fly   806 KKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQV 870
            :|:||||||:||.|:|:||||||
Human  1012 QKDGEWWTGSIGDRSGIFPSNYV------------------------------------------ 1034

  Fly   871 YQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMR 935
                   :|.:|                                   ||:.      |:...|..
Human  1035 -------KPKDQ-----------------------------------ESFG------SASKSGAS 1051

  Fly   936 AKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQ 1000
            .|:.|||||.:.|.|:.:|||||..||||:|.||..||||:|||||:|::||.|||||::||:|
Human  1052 NKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL- 1115

  Fly  1001 GGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNG 1065
             |.:|.|.||..        ..:.:|||:|.|.|.|:|||||.|..:|:|:.:|:|:||:||:||
Human  1116 -GPSSERATPAF--------HPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEING 1171

  Fly  1066 LSGLFPSNYVGPFVTSEIKPDPGACS------------RRSKG-IQRLWQQWRGCDID------- 1110
            ::||||||||.  :|::..|....|:            |:.:| |..|.|.......|
Human  1172 VTGLFPSNYVK--MTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEV 1234

  Fly  1111 ---QAAQHG-----------------DASNNKLRGIIQAVHITKRRDGQLMGC------------ 1143
               :.|:.|                 ..||.||   ::|:.:.|:..|:.|..
Human  1235 FQKRMAESGFLTEGEMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAAELS 1296

  Fly  1144 ---AYVRFECNELLAKSMLQENGNQ 1165
               ||:||...:|...::||:..::
Human  1297 HMQAYIRFCSCQLNGAALLQQKTDE 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	51/104 (49%)
		EH	18..83	CDD:238009	36/64 (56%)
		EH	184..279	CDD:197477	53/94 (56%)
		EH	195..261	CDD:238009	38/65 (58%)
		GBP_C	<366..467	CDD:303769	41/100 (41%)
		TACC	369..570	CDD:282818	68/208 (33%)
		coiled coil	432..443	CDD:293879	6/10 (60%)
		coiled coil	457..467	CDD:293879	4/9 (44%)
		TBPIP	<495..589	CDD:284512	24/108 (22%)
		SH3_Intersectin_1	674..728	CDD:212770	27/53 (51%)
		SH3_Intersectin_3	779..830	CDD:212772	32/50 (64%)
		SH3_Intersectin_4	941..998	CDD:212773	36/56 (64%)
		SH3_Intersectin_5	1025..1077	CDD:212774	31/51 (61%)
ITSN2	NP_006268.2	SH3_Intersectin2_4	1057..1115	CDD:212927	37/57 (65%)
		SH3_Intersectin2_5	1130..1183	CDD:212929	31/54 (57%)
		RhoGEF	1214..1394	CDD:214619	21/111 (19%)
		PH_13	1412..1554	CDD:318790
		C2_Intersectin	1555..1689	CDD:176021
		EH	15..107	CDD:197477	49/91 (54%)
		SOBP	<90..182	CDD:317654	27/95 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..241		7/24 (29%)
		EH	237..316	CDD:197477	44/78 (56%)
		Neuromodulin_N	<346..756	CDD:331332	115/436 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..378		9/27 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..752		8/62 (13%)
		SH3_Intersectin2_1	759..815	CDD:212921	28/55 (51%)
		INTAP	815..902	CDD:318758	17/86 (20%)
		SH3_Intersectin2_2	902..953	CDD:212923	0/50 (0%)
		SH3_Intersectin2_3	985..1036	CDD:212925	32/99 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154117
Domainoid	1	1.000	171	1.000	Domainoid score	I3751
eggNOG	1	0.900	-	-		E1_KOG1029
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	567	1.000	Inparanoid score	I1078
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45992
OrthoDB	1	1.010	-	-		D349276at33208
OrthoFinder	1	1.000	-	-		FOG0002286
OrthoInspector	1	1.000	-	-		otm41416
orthoMCL	1	0.900	-	-		OOG6_103215
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X1514
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800