DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and trip10a

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_017209563.1	Gene:	trip10a / 492762	ZFINID:	ZDB-GENE-041114-105	Length:	592	Species:	Danio rerio

Alignment Length:	639	Identity:	123/639 - (19%)
Similarity:	220/639 - (34%)	Gaps:	190/639 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 SQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRR-RKIMEDQQRKEREERERKEREE------ 365
            :|||:.:||            :...:||.:.::::. .|.:.:..:|...:|..||.:|
Zfish    18 TQSGLDLVD------------KYMKFVKERTDIEQNYAKQLRNLTKKYSPKRGSKEEQECRFSNH 70

  Fly   366 -------------ADKREKARLEAERKQQE---ELERQLQRQREIEMEKE---EQRKRELEAKEA 411
                         |.:||   |.||.....   ||.:.||   |::.|::   .:.|:..::.||
Zfish    71 QAFLDILNEMNDYAGQRE---LIAENMMINICVELNKYLQ---ELKQERKMHLSEAKKSQQSLEA 129

  Fly   412 ARKELE---KQRQQEWEQARIA---------EMNAQKEREQERVLKQKAH---------NTQLNV 455
            ..|:|:   |:.::||.:|..|         ::||.|...::  .||:||         .....|
Zfish   130 MYKQLDNSKKRFEREWREAEKAAQYADKTDQDLNATKADVEK--AKQQAHLRTHIAEDCKNDYAV 192

  Fly   456 ELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQER 520
            :|...|   ||.||..      .|::..:.:.::...:..:.:|:|......|....::.:.
Zfish   193 QLQKYN---KEQSQFY------FTDMPQIFNKLQDMDERRIKKMAQGYILFAETERHVMPII--- 245

  Fly   521 AKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISK-EIESKKEDIN--TNDVQ 582
                      |..|.|.......:||. ....::|.|.|...|.... :.|...:.||  ::|..
Zfish   246 ----------GKCLEGMTRAGTNVNAR-NDSMVLIEQHKSGFERPGDLDFEDYSQGINRASSDSS 299

  Fly   583 MSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNE--TSVSSAWDT---GSSSAWEETGTT 642
            :...|..|..|           ...:.....| :|:|::  :|..|.:.|   .|.:....:...
Zfish   300 LGTPKGPLELL-----------GKNKNKTFRL-FNKKSKLPSSSLSPYSTPPIPSPANGPPSPKF 352

  Fly   643 VTDPYAVASNDISALAAP-----------AVDLGG----------------------------PA 668
            ..||.:....:|:....|           .||..|                            ..
Zfish   353 GRDPLSYCLKEINKTVKPRISSFRTLKRTPVDTEGFTHLPPEQRRKRLQQKIDDMSKELQKEMDQ 417

  Fly   669 PEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGE 733
            .|...|.:.|||.|.:..:..:..|.   :....||.:.  |.||:|.:..|..|:      .|.
Zfish   418 SEALGKMKDVYEKNPQMGDPASLAPQ---IGQTAQNMDR--LRGELNKYESWLAEA------GGR 471

  Fly   734 VAPVAAVEAPVDAQVATVADTYNDNINTSSI----PAASADLTAAGDVEY--------------- 779
            ...:......::...|     :|.|.|..|.    |.|.:|.|......|
Zfish   472 GDSIRYSTHSINNNGA-----HNPNSNDGSCTLFSPGALSDETDPSQAIYTEFDDEFEEEELATP 531

  Fly   780 ---YIAAYPYESAEEGDLSFSAGEMVMVIKKE-GEWWTGTIGSR--TGMFPSNY 827
               ..|.|.:..:.||.:|...||::.|:::: |:.||....:.  .|..|::|
Zfish   532 IGQCTALYNFPGSSEGTISMQEGEVLAVVEEDKGDGWTRVRRNNGDEGYIPTSY 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769	33/127 (26%)
		TACC	369..570	CDD:282818	48/228 (21%)
		coiled coil	432..443	CDD:293879	3/10 (30%)
		coiled coil	457..467	CDD:293879	3/9 (33%)
		TBPIP	<495..589	CDD:284512	17/96 (18%)
		SH3_Intersectin_1	674..728	CDD:212770	14/53 (26%)
		SH3_Intersectin_3	779..830	CDD:212772	15/70 (21%)
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
trip10a	XP_017209563.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940