DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dap160 and itsn2b

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:XP_005158835.1 Gene:itsn2b / 445153 ZFINID:ZDB-GENE-050309-102 Length:1837 Species:Danio rerio


Alignment Length:1618 Identity:440/1618 - (27%)
Similarity:645/1618 - (39%) Gaps:568/1618 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGK 65
            ||.....||:||.||.|:.::|.:|.|..|:|||.:|:.||:||.||..:|..||||||.:.|||
Zfish     1 MNGGRSIWAITPEERDKHDQKFDSLLPAQGYVTGEKARNFFIQSGLPQPVLAAIWALADMNKDGK 65

  Fly    66 MNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAP 130
            |:..|||||.|||.:||:|.::|..| |.::.......|:|..........|..|:...||.:.|
Zfish    66 MDRLEFSIAMKLIKMKLQGQNLPTAL-PIIMKQPPVPAPTMPAAPLGMGAMPNVPMMPNVPILTP 129

  Fly   131 V-------VPVVAP------PVAVATVIS-------PPGVSVPSGPTPPTSNPP----------- 164
            :       :||:.|      ||::...||       |..:..|| |.|.||..|           
Zfish   130 IPIATMSPIPVMTPMMGTGLPVSMMPTISSQTLPNGPIAILQPS-PMPLTSTLPLSSSFSASPLG 193

  Fly   165 ----------------------SRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRS 207
                                  |..||::..:|   .....:|.|..|.:.||.|.||:.|:..|
Zfish   194 FSTTSMNKTSSLLDLGSSSSNSSPSTSLASNSP---KGGPSDWGVPQASRLKYRQQFNSLDKLMS 255

  Fly   208 GYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQE 272
            |||||.|.|..:..:.|.|..||.||.|:|:|.||:|..|||||||.|.:.|..|:.:|:.||.:
Zfish   256 GYLTGPQVRTAMATTLLTQTQLAAIWNLADVDKDGKLKADEFILAMHLVDMAKMGQPLPLALPSD 320

  Fly   273 WVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTA----GLPGQNKRKENY 333
            .|||:||      |.:.  .|..|:.| |.:|.::..    :.:.:|..    .|..::|.|:|.
Zfish   321 LVPPSLR------GKLG--ESMNGTTP-SIYAGLAED----LCEPEPPQKSRNNLTFEDKFKKNM 372

  Fly   334 VKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEK 398
            ..|.|||::||:::::|||:|.|.|.:|.|||.::||:...|.|.|::.|.|.:|:||||:|.::
Zfish   373 ELGNAELEKRRQVLQEQQRREEERRAQKAREEQERREREARELELKRKREEEIRLERQRELERQR 437

  Fly   399 EEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEK 463
            ||:|.:|||.||||:||||:|:|.|||:.|..|:..||..|||.::|.:|....|.:||..:..|
Zfish   438 EEERLKELERKEAAKKELERQQQLEWERRRKQELQNQKSEEQEDIIKLRAKKRSLEMELEAVGNK 502

  Fly   464 IKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSK 528
            .|::|.::.|.:......|..::.:..:||:.::|:|.|:.::::...||.|.|.|:.|...|.:
Zfish   503 QKQISDKLRDAQGRKRIHKNELEMINQKRDSCITEISSLQKQLEDFKRKLGQSTSEQQKLTDKLR 567

  Fly   529 ---------ASGAALGGENAQ--------QEQLNAA---FAHKQLIINQIK-------------- 559
                     |:...|.....:        :|||||.   .|.|...::|.|              
Zfish   568 SLSLNSVPTATVKTLQNNMEEKDLSCRKLKEQLNAVEKETAAKLADMDQYKKDIQDLRESQRMQE 632

  Fly   560 -----------DKVENISK----EIESKK-----------------------------------E 574
                       :|:..:.|    |:|.|:                                   .
Zfish   633 SALEKLRTIKEEKIRELKKRKQEELEKKRREEEEQKRIKLEKERQWQEKLRRDEEEKQRKIQEER 697

  Fly   575 DINTNDVQMSELKAELSALITKCEDLYK------------------------------------- 602
            |....:.:..|.:|.|.|...:.|...|                                     
Zfish   698 DAKLREEEERERQARLQAAKEQAERERKAREEEERRRREEEEERREQERRRLEEEDRRRRDEERR 762

  Fly   603 ----------------EYDVQRTSVLELKYNRKNE------------------------------ 621
                            |.:.:|...:.||..|:.|                              
Zfish   763 KLEEERRKLEEERRKLEDERKRQEEIRLKEEREREERRRAEEERRRKEEERREEERKREREEEER 827

  Fly   622 ----TSVSSAWDTGSSSAWEE----------------------------------------TGTT 642
                ...::..|.......||                                        ....
Zfish   828 RRHRAQEAAMRDAEERKRIEEERKRKEEERRKQEEEDRRRREEEQRKQDEERKRKQQQEEAAAAR 892

  Fly   643 VTD-----PYAVASNDISALAAPAVD-LGGPAPEG--------FVKYQAVYEFNARNAEEITFVP 693
            :.|     ...|.|:.:|||.....: .||..|.|        ...::|:|.|.|||.||::|..
Zfish   893 LRDDEQNKKNTVKSDLVSALLRGLEERKGGRRPLGTQHRRSAALTTFKALYPFTARNEEELSFES 957

  Fly   694 GDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEA---------------- 742
            .|:|.|......|.|||.|...|..||||||||||....| |||.|.:|                
Zfish   958 DDLIEVDESVEREQGWLYGSWQGKMGWFPESYVEKQTKSE-APVVAKQALKPQVSISVSKLSDGP 1021

  Fly   743 ---------------------------PVDAQ-------------------VATVAD-------- 753
                                       .|.||                   |.||.:        
Zfish  1022 GGSRLNSAFTPTHATGSTSSNHGQVVGNVQAQALCSWSAKTDNHLDFSKDDVITVLEQQENWWLG 1086

  Fly   754 -----------TYNDNINTSSIPAAS---ADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMV 804
                       ||...::||...|.|   :|.|...:.|.|:|.|.|||.|.|||:|:.|:.::|
Zfish  1087 ELDGVQGWFPKTYVTVLSTSDAQADSTDASDTTDGSNYEEYVALYTYESPEPGDLTFNEGDTILV 1151

  Fly   805 IKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQ 869
            .::|||||.|:||.|.|:||||||:..:..|:|               |:|              
Zfish  1152 SEREGEWWRGSIGDRAGLFPSNYVKPKETDTSS---------------LSG-------------- 1187

  Fly   870 VYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGM 934
                                                                      .|.||| 
Zfish  1188 ----------------------------------------------------------KSGTPG- 1193

  Fly   935 RAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVL 999
              |:.|:|||.....|...|||:|:.||||:|..|..||||.|||||:|::||.|||||::||:|
Zfish  1194 --KKPEVAQVTTACTAAGAEQLNLSPGQLILILNKNPSGWWLGELQARGKKRQKGWFPASHVKLL 1256

  Fly  1000 QGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELN 1064
              |.|||::||.:.|        :.:|||:|.|.|.|:|||||.|..:|:||.:..|:||:||||
Zfish  1257 --GSNSGKSTPATPS--------VGQVIAIYDYTAANEDELSFSKSQVINVLDKSNPDWWKGELN 1311

  Fly  1065 GLSGLFPSNYVGPFVTSEIKPDPGACS-------------RRSKGIQRLWQQWRGCDIDQAAQHG 1116
            |::||.|:|||.  :|::..|....|:             :|...|..|        ||...::.
Zfish  1312 GVTGLIPTNYVK--LTTDSDPSQQWCADQSTLESMSPKDRKRQDYIHEL--------IDTEEKYV 1366

  Fly  1117 D-------------ASNNKL------------RGIIQ-------AVHITKRRDGQLMGC------ 1143
            :             :.:|:|            |.:||       |:...|:..|..|..      
Zfish  1367 EDLQLVLEVFYKPMSESNRLSEAEMNMIFANWRELIQCSSKMLKALKARKKSGGDNMPVHMIGDI 1431

  Fly  1144 ---------AYVRFECNELLAKSMLQENGNQLVGKAVVVDWQPELP---KKRFRQWRC 1189
                     ||:||...:|...::||:.          .|.:|:..   ||....:||
Zfish  1432 LTSELSNMQAYIRFCSCQLEGAALLQQR----------TDQEPDFKTFLKKIATDYRC 1479

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477 46/93 (49%)
EH 18..83 CDD:238009 34/64 (53%)
EH 184..279 CDD:197477 45/94 (48%)
EH 195..261 CDD:238009 34/65 (52%)
GBP_C <366..467 CDD:303769 46/100 (46%)
TACC 369..570 CDD:282818 75/249 (30%)
coiled coil 432..443 CDD:293879 5/10 (50%)
coiled coil 457..467 CDD:293879 3/9 (33%)
TBPIP <495..589 CDD:284512 28/177 (16%)
SH3_Intersectin_1 674..728 CDD:212770 26/53 (49%)
SH3_Intersectin_3 779..830 CDD:212772 29/50 (58%)
SH3_Intersectin_4 941..998 CDD:212773 32/56 (57%)
SH3_Intersectin_5 1025..1077 CDD:212774 30/51 (59%)
itsn2bXP_005158835.1 EH 7..99 CDD:197477 46/92 (50%)
EH 19..83 CDD:238009 34/63 (54%)
Amelogenin <80..183 CDD:197891 27/104 (26%)
EH 232..327 CDD:197477 45/94 (48%)
EH 243..308 CDD:238009 33/64 (52%)
TAF4 <453..592 CDD:296797 40/138 (29%)
DUF4349 <559..691 CDD:305044 18/131 (14%)
SH3 936..992 CDD:302595 26/55 (47%)
SH3 1051..1102 CDD:302595 7/50 (14%)
SH3_Intersectin_3 1126..1177 CDD:212772 29/50 (58%)
SH3_Intersectin2_4 1198..1256 CDD:212927 33/57 (58%)
SH3_Intersectin2_5 1271..1324 CDD:212929 30/54 (56%)
RhoGEF 1355..1535 CDD:279015 26/143 (18%)
PH_ITSN 1562..1692 CDD:270084
PH 1576..1684 CDD:278594
C2_Intersectin 1695..1829 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170589267
Domainoid 1 1.000 180 1.000 Domainoid score I3454
eggNOG 1 0.900 - - E1_KOG1029
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 519 1.000 Inparanoid score I1232
OMA 1 1.010 - - QHG45992
OrthoDB 1 1.010 - - D349276at33208
OrthoFinder 1 1.000 - - FOG0002286
OrthoInspector 1 1.000 - - otm25765
orthoMCL 1 0.900 - - OOG6_103215
Panther 1 1.100 - - O PTHR11216
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 1 1.000 - - X1514
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1514.800

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