DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and CG9297

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster

Alignment Length:	373	Identity:	75/373 - (20%)
Similarity:	134/373 - (35%)	Gaps:	98/373 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   237 DIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPAS 301
            |:||||..|..         ::.:.|:.:|               ..:...:.|
  Fly   272 DLDGDGTNNSQ---------DEDLDGDGVP---------------NEKDDDLDG----------- 301

  Fly   302 RHASVSSQSGV-----GVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERK 361
                    .|:     |.||.|   |:|.::..|::......:.|       |....::|..:::
  Fly   302 --------DGILNEHDGDVDGD---GVPNEHDHKDSGENADDDDD-------DDDEDDKEAVKKR 348

  Fly   362 EREEADKREKARLEAERKQQEEL--------ERQLQRQREIEMEKEEQRKREL----EAKEAARK 414
            .:.|.|......:||.....||.        |...:.:.|:|..|||:.::|.    |.:.....
  Fly   349 SKREVDAAPVLDIEAPPSPAEEFPVEEEIVKEASAEEEAEVEAVKEEEPEQEAVQEPEPEPVVEP 413

  Fly   415 ELEKQR---QQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLN-EKIKELSQRICDTR 475
            |.|.|.   |||.|:|..||  |::|.:...|.:.:|....:..|.:... |.::|.:|......
  Fly   414 EAEVQPEPVQQEEEKAESAE--AKEEEKPAPVEEAEAEEESVQPEAAPKEPEAVQEEAQEDEPQT 476

  Fly   476 AGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQ 540
            .|..:.....|..:.:.:...........|.::...:||||.:|   :.|:.||:.
  Fly   477 DGAQDAADDDDDTKPEDELLWEGHIPENRRSRQHITELLQLDEE---FNAREKATD--------- 529

  Fly   541 QEQLNAAFAHKQLIINQIKDKVENISKEIES--KKEDINTNDVQMSEL 586
                |.|    ::|:..||...||..|.:|:  |..|::.......|:
  Fly   530 ----NVA----EIILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEI 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477	8/41 (20%)
		EH	195..261	CDD:238009	6/23 (26%)
		GBP_C	<366..467	CDD:303769	29/116 (25%)
		TACC	369..570	CDD:282818	49/216 (23%)
		coiled coil	432..443	CDD:293879	2/10 (20%)
		coiled coil	457..467	CDD:293879	1/10 (10%)
		TBPIP	<495..589	CDD:284512	21/94 (22%)
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	8/29 (28%)
		EHD	574..813	CDD:206740
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459014
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030