DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dap160 and pacsin3

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:XP_009301745.2 Gene:pacsin3 / 393964 ZFINID:ZDB-GENE-040426-984 Length:516 Species:Danio rerio


Alignment Length:539 Identity:109/539 - (20%)
Similarity:197/539 - (36%) Gaps:177/539 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   234 TLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQ---EWVPPNLRKIKSRPGSVSGVV--- 292
            |:..|| ||...|:|.:    .|.:..|  ||.....|   :|.    ||.:       |:|   
Zfish   106 TVKRID-DGYKLCNELV----SCFQERA--KIEKGYSQQLSDWA----RKWR-------GIVEKG 152

  Fly   293 SRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREE 357
            |:.|:...:.||.:::...:..:..:          .|||.|            :||.::....:
Zfish   153 SQYGTLEKAWHAFMNAADRLSEIHME----------LKENLV------------IEDSEKIRNWQ 195

  Fly   358 RER---------KEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAAR 413
            ::.         :|.::||       |..||.|:...|:|   :|:|..|:.......|.:.|..
Zfish   196 KDAFHKQMIGGFRETKDAD-------EGFRKAQKPWVRKL---KEVESTKKGYHSARKEERTALT 250

  Fly   414 KELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGV 478
            :|...:......|..:.:...:.|:     ..|:|             ||.||..:|..|     
Zfish   251 RETHAKADPTKSQDEVRKFTDRLEK-----CTQEA-------------EKAKERYERALD----- 292

  Fly   479 TNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQ 543
                               |:::...|..|...::.::|||                   |::.:
Zfish   293 -------------------ELNRCNPRYMEDMEQVFEITQE-------------------AEKNR 319

  Fly   544 LNAAFAHKQLIINQIKDKVEN---------ISKEIESKK--EDI----NT-------NDVQMSEL 586
            | ..|....|.|:|..|...|         :.:.|.:..  ||:    ||       |..|..|.
Zfish   320 L-CFFKEVLLDIHQHMDLSSNDRFRALYRDLGQTISAANDTEDLRWWRNTHGPGMSMNWPQFEEW 383

  Fly   587 KAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEET--GTTVTDPYAV 649
            ..|.:..|::     |:.:.:...|:.|       |::.||.|....:..|.|  |...:..::.
Zfish   384 SPEANRSISR-----KDRNSRSDDVVTL-------TNIVSAGDEPPQTLQETTRAGKDYSSDWSD 436

  Fly   650 ASNDISALAAPAVD-----LGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGW 709
            ..:....:||..||     :|       |:.:|:|::..:.|:|::|..|:.:| .|.:..|.||
Zfish   437 EESPKKYIAANGVDEEEKVVG-------VRVRALYDYTGQEADELSFKAGEELL-KLGEEDEQGW 493

  Fly   710 LAGEI-NGHTGWFPESYVE 727
            ..|:: :|..|.:|.:||:
Zfish   494 CKGQLTSGEKGLYPANYVQ 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477
EH 18..83 CDD:238009
EH 184..279 CDD:197477 13/47 (28%)
EH 195..261 CDD:238009 8/26 (31%)
GBP_C <366..467 CDD:303769 21/100 (21%)
TACC 369..570 CDD:282818 36/209 (17%)
coiled coil 432..443 CDD:293879 1/10 (10%)
coiled coil 457..467 CDD:293879 3/9 (33%)
TBPIP <495..589 CDD:284512 22/115 (19%)
SH3_Intersectin_1 674..728 CDD:212770 17/55 (31%)
SH3_Intersectin_3 779..830 CDD:212772
SH3_Intersectin_4 941..998 CDD:212773
SH3_Intersectin_5 1025..1077 CDD:212774
pacsin3XP_009301745.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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