DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and Cip4

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001097501.1	Gene:	Cip4 / 38534	FlyBaseID:	FBgn0035533	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	134/773 - (17%)
Similarity:	268/773 - (34%)	Gaps:	275/773 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   219 LVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKS 283
            :::.||.|:|..:  |::|::.:    |....:| |.|.:..|  |:            |....|
  Fly     1 MLKKKLAQITKKK--TVADLEAE----CVHSAIA-FTCVRVCA--KL------------LASGSS 44

  Fly   284 RPGSVSGVVSRPGSQPASRHAS-------------VSSQSGVGVVDADPTAGLPGQNKRKENYVK 335
            |..|.:.:.....|...|.:.|             :.:..|:..:|            :..|:::
  Fly    45 RSSSNNKLAESENSAQNSNNMSWGTELWDQNENLAIHTNRGIDALD------------KFANFLR 97

  Fly   336 GQAELD-----RRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIE 395
            .:..::     :.|:::::.|.|::||.:         .|...::|.|...:|: ..|..|||:.
  Fly    98 DRVAIETEYAGKLRRLVKNYQPKKKEEED---------NEFTSVQAFRNLLKEV-GDLAGQREVV 152

  Fly   396 MEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQ-LNVELST 459
            .|       .|:.:..|...|..:..:|               |:::.|...|...| |..:||:
  Fly   153 SE-------SLQLQIIAGVTLLSKTLRE---------------ERKKCLSDGATLQQNLTTQLSS 195

  Fly   460 LNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWE 524
            |:...:...:...|:...|.:.|      |...|.::|       |.:.:..|.:..::.:...:
  Fly   196 LDRAKRNYEKAYRDSEKAVDSYK------RADMDLNLS-------RAEVERYKNVMTSKIQQSDD 247

  Fly   525 AKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENI-SKEIESKKEDINTNDVQMSELKA 588
            ||::.:.......|.||:       |..:::..:.::::.: .|.....:|.|    |..:::::
  Fly   248 AKNEYANQLQKTNNLQQQ-------HYSMLLPSVLNRLQELDEKRTRGFREFI----VGAADVES 301

  Fly   589 ELSALITKC--------------EDLYK---EYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAW 636
            .::.:|.:|              ||.:|   .|....|...::.:...::....|..|:..|::.
  Fly   302 SVAPIIARCMEGIVKAGESINEKEDTFKVIERYQSGFTPPRDIPFEDLSKCDPDSVQDSHYSNST 366

  Fly   637 EE----TGTT----------VTDPYAVASNDISA------------------LAAPAVDL----- 664
            ..    .||.          :.:.:....|.::|                  |.|...:|
  Fly   367 SNHLTIRGTMSANKLKKRVGIFNIFGSNKNSLTADGQKEDFSDLPPNQRRKKLQAKIAELTQNIA 431

  Fly   665 -GGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEK 728
             ...|.:|.:|.:.|||.|:.....:|                   :.|::|.     .|..:||
  Fly   432 QETKARDGLMKMKIVYEANSSLGNPMT-------------------VEGQLNE-----SEHKLEK 472

  Fly   729 LEV-----------GEVAPVAAV-------------------------------EAPVDA----- 746
            |:|           ....|.|..                               :.|.||
  Fly   473 LKVDLKKYQGFLEKASQVPTATSSPQASRNQLQNGHRTSRHSNGSADDHHDDGDDQPDDAGSLSR 537

  Fly   747 -----QVATVADTYNDNINTSSIPAA---------------SADLTAAGDVEYY----------- 780
                 .||.:.:.:|:|.|.|:.|.:               ||:..|.|:..||
  Fly   538 SDSEDNVAQIQNGHNNNNNGSASPESGLGTSHTSLPGSGQGSANENAIGEDTYYETEVETLNPVG 602

  Fly   781 --IAAYPYESAEEGDLSFSAGEMVMVIK-KEGEWWT------GTIGSRTGMFPSNYVQ 829
              .|.||:|::.||.:..|.||.:.||: .:|:.||      .:.|...|..|::|::
  Fly   603 KCRALYPFEASSEGSIPMSEGEELQVIEIDQGDGWTRVRRENNSNGWDEGFVPTSYIE 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477	12/59 (20%)
		EH	195..261	CDD:238009	10/41 (24%)
		GBP_C	<366..467	CDD:303769	21/101 (21%)
		TACC	369..570	CDD:282818	36/202 (18%)
		coiled coil	432..443	CDD:293879	1/10 (10%)
		coiled coil	457..467	CDD:293879	3/9 (33%)
		TBPIP	<495..589	CDD:284512	13/94 (14%)
		SH3_Intersectin_1	674..728	CDD:212770	9/53 (17%)
		SH3_Intersectin_3	779..830	CDD:212772	20/71 (28%)
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
Cip4	NP_001097501.1	F-BAR_CIP4-like	69..319	CDD:153337	49/317 (15%)
		HR1_CIP4-like	412..488	CDD:212009	18/99 (18%)
		SH3_CIP4-like	603..661	CDD:212844	18/58 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030