DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and Reps

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_609487.2	Gene:	Reps / 34542	FlyBaseID:	FBgn0032341	Length:	907	Species:	Drosophila melanogaster

Alignment Length:	712	Identity:	141/712 - (19%)
Similarity:	254/712 - (35%)	Gaps:	168/712 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VDAWAVTPRERLKYQEQFRALQPQA-GFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68
            |..:.:||.:|..|.:|||.:|... |.::|..|:.||.:|::|...|..||.|.|...||.:::
  Fly   257 VTIYQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIPVEELRHIWQLCDVTRDGALSL 321

  Fly    69 NEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVV- 132
            :||:.|..|:.|:...:.:|..||..|..::.....|.:.:|.|||.|...|.:   |..|.::
  Fly   322 SEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVLQAAASGSGQGVTSSSSAALPQE---PPEADLLH 383

  Fly   133 ------------PVVAPPVAVATVISPPGVSVPS------------------------------G 155
                        .::|..::.::..|.|..:|||                              |
  Fly   384 LNDDDEDDHTDNTIIAGNLSGSSTTSKPRPNVPSDKNIMNLSSISTSSQASNSSKREATPQNSLG 448

  Fly   156 PTPPTSNPPSRHT----SISERAPSIESVN-QGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQA 215
            .....||.|:...    ::|..|.:::|.| ..:|.       |:::              ....
  Fly   449 KNRSISNSPNVEKPVSGTVSSTASAVDSTNVSSQWT-------KFSE--------------SPTT 492

  Fly   216 RGVLVQS---KLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPN 277
            ..|.|||   ..|.|......:.:...|          |...|.:...:.:.: |:.||...|..
  Fly   493 SAVSVQSTTGAAPVVAAGAAASGASSPG----------LKPVLFDMKRSAQDV-VSNPQILHPVP 546

  Fly   278 LR----------KIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKEN 332
            ||          ..:|...:.|.|..|..|..|....:|::||         :|.:||
  Fly   547 LRVTPIGTAIASSAESSNENESAVAQREDSPKAISSTTVNNQS---------SAVVPG------- 595

  Fly   333 YVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAER--KQQEELERQLQRQREI- 394
             :.|.|                    ....|:.:|.|...|.:|::  .:...|....||:..|
  Fly   596 -ISGVA--------------------GSSHRDSSDLRAIQRPQAKKLPAKNSALPPPPQREPSIG 639

  Fly   395 ---EMEKEEQRKRELEAKEAARKE---LEKQRQQEWEQARIAEMN-----AQKEREQERVLKQKA 448
               ..|.:|.:...:.:..|::||   |...|.....::...::|     |....:|..:..|.:
  Fly   640 STGPSESQEPQAAYVASSLASKKEPPPLPPPRPHRHARSSSLDLNKFKIGATGGAQQAEITAQAS 704

  Fly   449 HNTQLNVELSTLNEKIKELSQRICDTR-------AGVTNVKTVIDGMRTQRDTSMSEMSQLKARI 506
            .:.|.:...:.......|.:..:.|.:       |.......|:...|.....:...:|..:...
  Fly   705 FDMQTSTGFADFTHFADEGAANVVDEQQLHSLPPAAPPPQAAVVPPTRITLQQAQQRVSAFEVYR 769

  Fly   507 KEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISKEIES 571
            |.|       |...::...:.....|...|...|..||.:|.:.::. :..|.|.:.::|    .
  Fly   770 KPQ-------TPRGSQSPPQQPPPPAPAVGLTTQTGQLPSAESFEKR-VTAISDSLRHVS----F 822

  Fly   572 KKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSS 633
            |:...||.:| :..|:.:.::|:..|.||..|....:|...|::...:...:..|...|.||
  Fly   823 KQGQANTTEV-LQRLREQNNSLLHLCNDLSDELLSVQTRKEEMRLKLEGLNASDSTGRTSSS 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	31/94 (33%)
		EH	18..83	CDD:238009	24/65 (37%)
		EH	184..279	CDD:197477	15/97 (15%)
		EH	195..261	CDD:238009	9/68 (13%)
		GBP_C	<366..467	CDD:303769	20/114 (18%)
		TACC	369..570	CDD:282818	37/221 (17%)
		coiled coil	432..443	CDD:293879	3/15 (20%)
		coiled coil	457..467	CDD:293879	0/9 (0%)
		TBPIP	<495..589	CDD:284512	18/93 (19%)
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
Reps	NP_609487.2	EH	262..345	CDD:197477	28/82 (34%)
Reps	NP_609487.2	EH	270..336	CDD:238009	24/65 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	60	1.000	Domainoid score	I3847
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm2552
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11216
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.100