DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and ehd2b

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_956357.1	Gene:	ehd2b / 337401	ZFINID:	ZDB-GENE-030131-9347	Length:	543	Species:	Danio rerio

Alignment Length:	194	Identity:	59/194 - (30%)
Similarity:	86/194 - (44%)	Gaps:	24/194 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAPPVAVATVISPPGVSVP 153
            |.|.|:|:        :|.....:|.::.|.||.......|.|.|.|.....:.|...|   .|.
Zfish   370 KALKPNLM--------NMLDELLSSDIAKLMPLLRQEEIEAGVQPGVQGGAFLGTRAGP---FVE 423

  Fly   154 SGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGV 218
            ..|....:|   .:..:.|        ...||.| ...|.||.::| .|.....|.|:|::|:..
Zfish   424 GDPFGEVAN---ENGEVGE--------EDEEWVV-TKDKPKYDEIF-YNLAPNEGKLSGTKAKDW 475

  Fly   219 LVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIK 282
            :|.::||...|.:||.|||:|.||.|:.:||.||..|.|..:.|..:|..||...|||:.|:.|
Zfish   476 MVSTRLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEVKLDGHGLPPELPARLVPPSKRRQK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	4/11 (36%)
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477	38/94 (40%)
		EH	195..261	CDD:238009	26/65 (40%)
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
ehd2b	NP_956357.1	EHD_N	22..54	CDD:293485
		EHD	58..298	CDD:206740
		EH	443..536	CDD:197477	38/94 (40%)
		EH	453..517	CDD:238009	26/64 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589263
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840