DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dap160 and Itsn2

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:XP_038969030.1 Gene:Itsn2 / 313934 RGDID:1590890 Length:1716 Species:Rattus norvegicus


Alignment Length:1495 Identity:436/1495 - (29%)
Similarity:660/1495 - (44%) Gaps:493/1495 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNSAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGK 65
            ||...:.||:|..||.|:.:||..|:|..|::||.||:.|||||.||..:|.:||||:|.:.|||
  Rat     9 MNGGPNMWAITSEERTKHDKQFDNLKPSGGYITGDQARTFFLQSGLPAPVLAEIWALSDLNKDGK 73

  Fly    66 MNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTP-------RGSTSSLSPLDPLKG 123
            |:..|||||.|||.|||:|..:|.||||     :....|..:|       .||..:||...||..
  Rat    74 MDQQEFSIAMKLIKLKLQGQQLPVVLPP-----IMKQPPMFSPLISARFGMGSMPNLSIHQPLPP 133

  Fly   124 IVPAVAP---------VVPVVAP------------PVAVATVISPPGVSVP-SGPTPP------- 159
            :.|..||         :.|::.|            |...|::|.|  :|:| |..|.|       
  Rat   134 VAPITAPLSSATSGTSIPPLMMPAPLVPSVSTSSLPNGTASLIQP--LSIPYSSSTLPHASSYSL 196

  Fly   160 --------------------TSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDR 204
                                :|:..|...|:|..:|   .....||||....:.||.|.||:.|:
  Rat   197 MMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSP---KTGTSEWAVPQPSRLKYRQKFNSLDK 258

  Fly   205 TRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTL 269
            :.||||:|.|||..|:||.|.|..||.||||:||||||:|..:||||||.|.:.|.||:.:|:||
  Rat   259 SMSGYLSGFQARNALLQSNLSQTQLATIWTLADIDGDGQLKAEEFILAMHLTDMAKAGQPLPLTL 323

  Fly   270 PQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLP--GQNKRKEN 332
            |.|.|||:.|..| :..|::|.:  |..|...              :.:|...||  .::|||.|
  Rat   324 PPELVPPSFRGGK-QIDSINGTL--PSYQKTQ--------------EEEPQKKLPVTFEDKRKAN 371

  Fly   333 YVKGQAELDRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEME 397
            |.:|..||::||:::.:||::|.|.:.:||:||.:::::...|.|.|:|.|||::|::|||:|.:
  Rat   372 YERGNMELEKRRQVLMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ 436

  Fly   398 KEEQRKRELEAKE---------------------------------AARKELEKQRQQEWEQARI 429
            :||:|::|:|.:|                                 ||::|||:||:.|||:.|.
  Rat   437 REEERRKEIERRESCISFPLMREREWISVYKDRKGFMAELWKPGSCAAKQELERQRRLEWERIRR 501

  Fly   430 AEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDT 494
            .|:..||.||||.:::..:....|::||..:|.|.:::|.|:.|.|......||.::.:..|.|.
  Rat   502 QELLNQKNREQEEIVRLNSKKKSLHLELEAVNGKHQQISGRLQDVRIRKQTQKTELEVLDKQCDL 566

  Fly   495 SMSEMSQLKARIKEQNAKLL------QLTQERAKWEAKSKA--SGAALGGENAQQEQLNAAFAHK 551
            .:.|:.||:..::|...||:      ||..||.|....|..  ||.:|         |:...:.|
  Rat   567 EIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQLSNTPDSGISL---------LHKKSSEK 622

  Fly   552 QLIINQIKDKVENISKEIESKKEDINTNDVQM-------SELKAELSALITKC--------EDLY 601
            :.:..::|::::.:.||..||..::::.:.|:       |.|:..||.|  .|        ::|.
  Rat   623 EELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLL--SCLNNLFLLLKELR 685

  Fly   602 KEYDVQRTSV------------------LELKYNRKNETSVSSAWDTGSSSAWEET--------- 639
            :.|:.|:.::                  ||....:|.|...:.....|..:.|:|:         
  Rat   686 ESYNTQQLALEQLHKIKRDKLKELERKRLEQIQKKKLEDEAARKAKQGKENLWKESIRKEEEEKQ 750

  Fly   640 ----------GTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPG 694
                      .|...:....|....:|.|             .|.|:|:|.|.|||.:|::|..|
  Rat   751 KRLQEEKSQDRTQEEERKTEAKQSETARA-------------LVNYRALYPFEARNHDEMSFNSG 802

  Fly   695 DIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAP---------------VAAVEAPV 744
            |||.|..:...|||||.|...|..||||.:||||:...:..|               .:|...|:
  Rat   803 DIIQVDEKTVGEPGWLYGSFQGKFGWFPCNYVEKMLSSDKTPSPKKALLPPAVSLSATSAAPQPL 867

  Fly   745 -DAQVATVADTYN---DNINTSSI------------PAASADLTAAG------------------ 775
             ..|.|.|.|..|   .|:|.::.            |.:.:.:...|                  
  Rat   868 CSNQPAPVTDYQNVSFSNLNVNTTWQQKSAFTRTVSPGSVSPIHGQGQAVENLKAQALCSWTAKK 932

  Fly   776 ---------DV------------------------------------------------------ 777
                     ||                                                      
  Rat   933 ENHLNFSKHDVITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKRGEPEALYAAVNKKPTST 997

  Fly   778 -----EYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTAS 837
                 |.|||.|.|.|.|.|||:|:.||.::|.:|:||||||:||.|||:||||||:..      
  Rat   998 AYPVGEEYIALYSYSSVEPGDLTFTEGEELLVTQKDGEWWTGSIGERTGIFPSNYVRPK------ 1056

  Fly   838 TAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEV 902
                      |||..  |||                                             
  Rat  1057 ----------DQENV--GNA--------------------------------------------- 1064

  Fly   903 SQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIR 967
                  ||:.:|.                     |:.|||||.:.|.|:..|||||..||||:|.
  Rat  1065 ------SKSGASN---------------------KKPEIAQVTSAYAASGAEQLSLAPGQLILIL 1102

  Fly   968 KKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPY 1032
            ||..||||:|||||:|::||.|||||::||:|  |.::.|.||..        ..:.:|||:|.|
  Rat  1103 KKNSSGWWQGELQARGKKRQKGWFPASHVKLL--GPSAERTTPAF--------HAVCQVIAMYDY 1157

  Fly  1033 KAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACS------ 1091
            .|.|:|||:|.|..:|:|:.:|:|:||:||:||::||||||||.  :|::..|....|:      
  Rat  1158 IANNEDELNFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK--MTTDSDPSQQWCADLQALD 1220

  Fly  1092 ------RRSKG------------------IQRLWQQWRGCDIDQAAQHG---DA----------- 1118
                  |:.:|                  :..::|:       :.|:.|   :|           
  Rat  1221 TMQPMERKRQGYIHELIETEERYMDDLQLVIEVFQK-------RMAESGFLTEAEMALIFVNWKE 1278

  Fly  1119 ---SNNKLRGIIQAVHITKRRDG-----QLMG----------CAYVRFECNELLAKSMLQENGNQ 1165
               ||.||   ::|:.:.|:..|     ::||          .||:||...:|...::||:..::
  Rat  1279 LIMSNTKL---LKALRVRKKTGGEKMPVEMMGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDE 1340

  Fly  1166  1165
              Rat  1341  1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477 49/93 (53%)
EH 18..83 CDD:238009 36/64 (56%)
EH 184..279 CDD:197477 54/94 (57%)
EH 195..261 CDD:238009 39/65 (60%)
GBP_C <366..467 CDD:303769 41/133 (31%)
TACC 369..570 CDD:282818 69/241 (29%)
coiled coil 432..443 CDD:293879 6/10 (60%)
coiled coil 457..467 CDD:293879 3/9 (33%)
TBPIP <495..589 CDD:284512 25/108 (23%)
SH3_Intersectin_1 674..728 CDD:212770 27/53 (51%)
SH3_Intersectin_3 779..830 CDD:212772 32/50 (64%)
SH3_Intersectin_4 941..998 CDD:212773 36/56 (64%)
SH3_Intersectin_5 1025..1077 CDD:212774 30/51 (59%)
Itsn2XP_038969030.1 EH 15..107 CDD:197477 49/96 (51%)
KLF3_N 106..>185 CDD:410554 19/80 (24%)
EH 238..317 CDD:197477 45/78 (58%)
PTZ00121 <347..797 CDD:173412 122/487 (25%)
SH3_Intersectin2_1 780..836 CDD:212921 28/55 (51%)
SH3_Intersectin2_2 921..972 CDD:212923 2/50 (4%)
SH3_Intersectin2_3 1004..1055 CDD:212925 32/50 (64%)
SH3_Intersectin2_4 1076..1134 CDD:212927 37/57 (65%)
SH3_Intersectin2_5 1149..1202 CDD:212929 30/54 (56%)
RhoGEF 1233..1413 CDD:214619 20/118 (17%)
PH_13 1431..1574 CDD:406942
C2_Intersectin 1574..1708 CDD:176021
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166347730
Domainoid 1 1.000 171 1.000 Domainoid score I3641
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 593 1.000 Inparanoid score I936
OMA 1 1.010 - - QHG45992
OrthoDB 1 1.010 - - D349276at33208
OrthoFinder 1 1.000 - - FOG0002286
OrthoInspector 1 1.000 - - otm45532
orthoMCL 1 0.900 - - OOG6_103215
Panther 1 1.100 - - O PTHR11216
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1514
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1211.910

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