DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and Eps15

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_038965889.1	Gene:	Eps15 / 313474	RGDID:	1305550	Length:	933	Species:	Rattus norvegicus

Alignment Length:	848	Identity:	186/848 - (21%)
Similarity:	337/848 - (39%)	Gaps:	243/848 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFS 72
            |||...::.||...|.:|.|..||::|.:.|...|.|:||..|||::|.|:|.|.|||::.:||:
  Rat   122 WAVKSEDKAKYDAIFDSLSPVDGFLSGDKVKPVLLNSKLPVEILGRVWELSDIDHDGKLDRDEFA 186

  Fly    73 IACKLINLKLRGMDVPKVLPPSLLS-------SLTGD---VPSMTPRGSTSSLSPLDPLKGIVPA 127
            :|..|:...|....||..|||:|:.       |::|.   :||...:.|..||.|:    ||.|.
  Rat   187 VAMFLVYCALEKEPVPMSLPPALVPPSKRKTVSISGSMWAIPSSAAKESYHSLPPV----GISPT 247

  Fly   128 VAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQK 192
            .||:                                                   .:|.|..|:|
  Rat   248 KAPL---------------------------------------------------RQWVVSPAEK 261

  Fly   193 RKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLC- 256
            .||.::|...|:...||::|.:.|...:::.||...||.||.|.|....|:|:.|:|.||..|.
  Rat   262 AKYDEIFLKTDKDMDGYVSGLEVRETFLKTGLPSTLLAHIWALCDTKNCGKLSKDQFALAFHLIN 326

  Fly   257 EKAMAGEKIPVTLPQEWVPP----NLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVG--VV 315
            :|.:.|...|.:|..|.:||    :|:|            :..||.|.:..:::.....:.  ::
  Rat   327 QKLIKGIDPPHSLTPEMIPPSDKSSLQK------------NTIGSSPVADFSAIKELDTLNNEII 379

  Fly   316 DADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEA-DKREKARLEAERK 379
            |.          :|::|.|              :|..||:|:..|:...|| |.:::.:.|:...
  Rat   380 DL----------QREKNNV--------------EQDLKEKEDTVRQRTTEAQDLQDEVQRESLNL 420

  Fly   380 QQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQAR-IAEMNAQKEREQERV 443
            |  :|:.|.|:.:|:..|.:|| |.:||      ::|::.|::..|:|: |:.:.|:       :
  Rat   421 Q--KLQAQKQQVQELLDELDEQ-KAQLE------EQLKEVRKKCAEEAQLISSLKAE-------I 469

  Fly   444 LKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKE 508
            ..|::..:....|||...|::..|.|........|.:.|..::.::.....|..|:|.::.|:.
  Rat   470 TSQESQISTYEEELSKAREELSRLQQETAQLEESVESGKAQLEPLQQHLQDSQQEISSMQMRLA- 533

  Fly   509 QNAKLLQLTQERAKWEAKSKA---SGAA----LGGENAQQEQLNAAFAHKQLIINQIKDKVENIS 566
              .|.|:....::.|.:..::   :|||    |...:::...|| ..|..|   |.::.:..:..
  Rat   534 --MKDLETDNNQSNWCSSPQSILVNGAADYCSLSTSSSETANLN-EHAEGQ---NNLESEPIHPE 592

  Fly   567 KEIESKKEDINTNDVQMSELKAELSALITKC--EDLYKEYDVQRTSVLELKYNRKNETSVSSAWD 629
            ..:.|..| |..:||      .:.|.::|..  |.:...:|..:.|..|..:|.::.:...:..|
  Rat   593 SSVRSSPE-IAPSDV------TDESEVVTAADIEKVSPRFDDDKHSKEEDPFNVESSSLTDAVAD 650

  Fly   630 T-----------GSSSAWEE-------------TGT-----------TVTDPYAVASNDISALAA 659
            |           ||....::             .|:           |.|||:|.:|.|..:.::
  Rat   651 TNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFKQTSTDPFATSSTDPFSASS 715

  Fly   660 PAVDLGGPAPEGFVKYQAVYEFNARNAEEIT------FVPGDIILVPLEQNAEPGWLAGEINGHT 718
                                  |:.|....|      |.||..::...:...:|   ...:.|:.
  Rat   716 ----------------------NSSNTSVETWKHNDPFAPGGTVVAATDSATDP---FASVFGNE 755

  Fly   719 GWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSS------------IPAASADL 771
            . |.:.:.:...:.:|:.               .|.:|..|::|:            .|:.|.|:
  Rat   756 S-FGDGFADFSTLSKVSN---------------EDPFNPTISSSASSVVIPKPVLEETPSKSEDV 804

  Fly   772 TAA 774
            ..|
  Rat   805 PPA 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	38/99 (38%)
		EH	18..83	CDD:238009	26/64 (41%)
		EH	184..279	CDD:197477	34/99 (34%)
		EH	195..261	CDD:238009	23/66 (35%)
		GBP_C	<366..467	CDD:303769	25/102 (25%)
		TACC	369..570	CDD:282818	43/208 (21%)
		coiled coil	432..443	CDD:293879	1/10 (10%)
		coiled coil	457..467	CDD:293879	3/9 (33%)
		TBPIP	<495..589	CDD:284512	21/100 (21%)
		SH3_Intersectin_1	674..728	CDD:212770	9/59 (15%)
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
Eps15	XP_038965889.1	EH	13..103	CDD:197477
		EH	121..215	CDD:197477	37/92 (40%)
		EH	253..349	CDD:197477	34/95 (36%)
		Smc	<369..>540	CDD:224117	45/213 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347736
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840