DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and EHD2

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_055416.2	Gene:	EHD2 / 30846	HGNCID:	3243	Length:	543	Species:	Homo sapiens

Alignment Length:	221	Identity:	65/221 - (29%)
Similarity:	90/221 - (40%)	Gaps:	50/221 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 CKLINLKLRGMDVPKV--LPPSLLSS----LTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVP 133
            |:.:...|...|..|.  |.|.||.:    ||.|:..:.|......|...:
Human   356 CQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTE-------------- 406

  Fly   134 VVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAP--SIESVNQG-----EWAVQAAQ 191
                            |.|..|....|...|     ..||.|  ::|...:|     ||.| ...
Human   407 ----------------VGVQGGAFEGTHMGP-----FVERGPDEAMEDGEEGSDDEAEWVV-TKD 449

  Fly   192 KRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLC 256
            |.||.::| .|.....|.|:||:|:..:|.:|||...|.:||.|||:|.||.|:.:||.||..|.
Human   450 KSKYDEIF-YNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLI 513

  Fly   257 EKAMAGEKIPVTLPQEWVPPNLRKIK 282
            |..:.|..:|..||:..|||:.|:.|
Human   514 EAKLEGHGLPANLPRRLVPPSKRRHK 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	9/31 (29%)
		EH	18..83	CDD:238009	1/7 (14%)
		EH	184..279	CDD:197477	40/94 (43%)
		EH	195..261	CDD:238009	28/65 (43%)
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
EHD2	NP_055416.2	EHD_N	24..56	CDD:374864
		EHD	60..300	CDD:206740
		G1 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	65..72
		G2 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	91..92
		KPF loop, caveolar targeting. /evidence=ECO:0000269\|PubMed:22323287	120..122
		G3 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	153..156
		G4 motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01055	219..222
		DUF5600	288..394	CDD:375591	11/37 (30%)
		Mediates membrane-binding. /evidence=ECO:0000250\|UniProtKB:Q8BH64	320..340
		EH	443..536	CDD:197477	40/94 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	523..543		8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154115
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840