DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and Itsn1

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_038944174.1	Gene:	Itsn1 / 29491	RGDID:	2935	Length:	1718	Species:	Rattus norvegicus

Alignment Length:	1486	Identity:	430/1486 - (28%)
Similarity:	652/1486 - (43%)	Gaps:	474/1486 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68
            ::|.||:|..||.|:.:||::|:|.:||:||.||:.||.||.||..:|.|||||||.:.||:|:.
  Rat    11 SLDIWAITVEERAKHDQQFQSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNKDGRMDQ 75

  Fly    69 NEFSIACKLINLKLRGMDVPKVLPPSL--------------LSSLTGDVPSMT-----PRGSTSS 114
            .|||||.|||.|||:|..:|..|||.:              :..:.| :|.:|     |.||.
  Rat    76 VEFSIAMKLIKLKLQGYQLPPALPPVMKQQPAAISSAPAFGIGGMAG-MPPLTAVAPVPMGSI-- 137

  Fly   115 LSPLDPLKGIVPAVAPVVPVVA-PPVA--VATVISP------PGVSVPSGPTPPTSNPPSRHTSI 170
                 |:.|:.|.:...||..| ||:|  ...||.|      |..::|...:...|.|.|:..:.
  Rat   138 -----PVVGMSPPLVSSVPQAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTK 197

  Fly   171 SERAPSIESVN---QGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQI 232
            .::|.|.:..:   ..||||..:.:.||.|:||::|:|.||:|||.|||.:|:||.|||..||.|
  Rat   198 LQKAQSFDVASAPAAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASI 262

  Fly   233 WTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPG----SVSGVVS 293
            |.|||||.||:|..:||||||.|.:.||:|:.:|..||.|::||:.|:::|..|    |.|....
  Rat   263 WNLSDIDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSADQ 327

  Fly   294 RPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKENYVKGQAELDRRRKIMEDQQRKEREER 358
            |...:|:|....          ..:....:..::|::||:.:|..||::||:.:.:|||||:|..
  Rat   328 RLPEEPSSEDEQ----------QVEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERL 382

  Fly   359 ERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQE 423
            .:.||.|.:::|:.|.|.|||:|.|||:||::|||:|.::||:|::|:|.:|||::|||:|||.|
  Rat   383 AQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLE 447

  Fly   424 WEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGM 488
            ||:.|..|:..|:.::||.::..||....|..||..||:|..:|..::.|.|..:...:..|:..
  Rat   448 WERNRRQELLTQRNKDQEGIVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIEST 512

  Fly   489 RTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQ---------- 543
            ...|:..::|::.|:.:::|....|.:|..|:           ..|..:..|.:|
  Rat   513 NKSRELRIAEITHLQQQLQESQQMLGRLIPEK-----------QILSDQLKQVQQNSLHRDSLLT 566

  Fly   544 LNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDV-- 606
            |..|...|:|...|::::::.:.||..||.::|:..:.|:.||:.     |...:.|.|:..:
  Rat   567 LKRALEAKELARQQLREQLDEVEKETRSKLQEIDVFNNQLKELRE-----IHSKQQLQKQRSIEA 626

  Fly   607 -------QRTSVLELKYNR-----------------------------------KNETSVSSAWD 629
                   |....|||:..:                                   |.|.||.
  Rat   627 ERLKQKEQERKSLELEKQKEEGQRRVQERDKQWQEHVQQEEQQRPRKPHEEDKLKREDSVK---- 687

  Fly   630 TGSSSAWEETGTTVTDPYAVASNDISALAAPA-----------VDLGGPAPEGFVKYQAVYEFNA 683
              ...|.|.....|.|..:...:.....|.||           :.:........|.|:|:|.|.:
  Rat   688 --KKEAEERAKPEVQDKQSRLFHPHQEPAKPAQAPWPTTEKGPLTISAQESAKVVYYRALYPFES 750

  Fly   684 RNAEEITFVPGDIILVPLE-----QNAEPGWLAGEINGHTGWFPESYVEKLEVGEV--------- 734
            |:.:|||..||||::|..|     |..|||||.||:.|.|||||.:|.||:...|:
  Rat   751 RSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEIPTPAKPVTD 815

  Fly   735 -----APVAAVE---APVDAQVATVADTYN-------------------DNINT------SSIPA 766
                 ||..|:.   ||:....:..:.|.|                   ||.:|      .::|:
  Rat   816 LTSAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSTNEKPETDNWDTWAAQPSLTVPS 880

  Fly   767 AS--------ADLTAAG-------------------------------------DV--------- 777
            |.        ...||.|                                     ||
  Rat   881 AGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDM 945

  Fly   778 --------------------------------------------------------EYYIAAYPY 786
                                                                    |.::|.|.|
  Rat   946 WWFGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTEAPSSLKRVASPAAKPAIPGEEFVAMYTY 1010

  Fly   787 ESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQET 851
            ||:|.|||:|..|::::|.||:|:|||||:|..:|:||||||:..|
  Rat  1011 ESSEHGDLTFQQGDVIVVTKKDGDWWTGTVGETSGVFPSNYVRLKD------------------- 1056

  Fly   852 TLNGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEP 916
                                              |.|.|                |..||
  Rat  1057 ----------------------------------SEGSG----------------TAGKT----- 1066

  Fly   917 AESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQA 981
                            |...|:.|||||||.|.||..|||:|..||||:||||...|||||||||
  Rat  1067 ----------------GSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQA 1115

  Fly   982 KGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDD 1046
            :|::||||||||.|||:|..|  :.:.||....:..:...:. :||.:|.|.|||||||:|.|..
  Rat  1116 RGKKRQIGWFPANYVKLLSPG--TSKITPTELPKTAVQPAVC-QVIGMYDYTAQNDDELAFSKGQ 1177

  Fly  1047 IISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACS------------RRSKG-IQ 1098
            ||:||.:::|:||:||::|..||||||||.  :|:::.|....||            |:.:| |.
  Rat  1178 IINVLSKEDPDWWKGEVSGQVGLFPSNYVK--LTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIH 1240

  Fly  1099 RL---------------------------------------WQQWRGCDIDQAAQHGDASNNKLR 1124
            .|                                       |::...|:|.
  Rat  1241 ELIVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNIK-------------- 1291

  Fly  1125 GIIQAVHITKRRDGQLMGC---------------AYVRFECNELLAKSMLQENGNQ 1165
             :::|:.:.|:..|:.|..               .|:||...:|...:::|:..::
  Rat  1292 -LLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDE 1346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	49/107 (46%)
		EH	18..83	CDD:238009	37/64 (58%)
		EH	184..279	CDD:197477	53/94 (56%)
		EH	195..261	CDD:238009	40/65 (62%)
		GBP_C	<366..467	CDD:303769	46/100 (46%)
		TACC	369..570	CDD:282818	67/210 (32%)
		coiled coil	432..443	CDD:293879	3/10 (30%)
		coiled coil	457..467	CDD:293879	4/9 (44%)
		TBPIP	<495..589	CDD:284512	22/103 (21%)
		SH3_Intersectin_1	674..728	CDD:212770	29/58 (50%)
		SH3_Intersectin_3	779..830	CDD:212772	28/50 (56%)
		SH3_Intersectin_4	941..998	CDD:212773	41/56 (73%)
		SH3_Intersectin_5	1025..1077	CDD:212774	31/51 (61%)
Itsn1	XP_038944174.1	EH	14..106	CDD:197477	49/91 (54%)
		gliding_GltJ	<93..>184	CDD:411345	24/98 (24%)
		EH	217..309	CDD:197477	50/91 (55%)
		SMC_prok_B	<347..657	CDD:274008	97/325 (30%)
		tolA	615..>719	CDD:236545	17/109 (16%)
		SH3	741..800	CDD:418401	29/58 (50%)
		INTAP	800..914	CDD:406913	17/113 (15%)
		SH3_Intersectin1_2	914..965	CDD:212922	2/50 (4%)
		SH3	1003..1054	CDD:418401	28/50 (56%)
		SH3_Intersectin1_4	1071..1135	CDD:212926	45/63 (71%)
		SH3_Intersectin1_5	1155..1208	CDD:212928	31/55 (56%)
		RhoGEF	1235..1418	CDD:238091	15/127 (12%)
		PH_13	1437..1579	CDD:406942
		C2_Intersectin	1579..1713	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347732
Domainoid	1	1.000	171	1.000	Domainoid score	I3641
eggNOG	1	0.900	-	-		E1_KOG1029
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2277
Inparanoid	1	1.050	593	1.000	Inparanoid score	I936
OMA	1	1.010	-	-		QHG45992
OrthoDB	1	1.010	-	-		D349276at33208
OrthoFinder	1	1.000	-	-		FOG0002286
OrthoInspector	1	1.000	-	-		otm45532
orthoMCL	1	0.900	-	-		OOG6_103215
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1514
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810