DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and SH3YL1

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_056492.2	Gene:	SH3YL1 / 26751	HGNCID:	29546	Length:	342	Species:	Homo sapiens

Alignment Length:	326	Identity:	68/326 - (20%)
Similarity:	120/326 - (36%)	Gaps:	117/326 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   766 AASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQK 830
            |...:||..|::.  :|..|.....||:::..:...|....|          || |:|
Human   115 AKGGNLTLGGNLT--VAVGPLGRNLEGNVALRSSAAVFTYCK----------SR-GLF------- 159

  Fly   831 ADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVY--QPLPVQEPSEQPISSPGVGAEE 893
            |.|....:...|..|:         |..:....:.|.:.::  .|.|.|             ||:
Human   160 AGVSLEGSCLIERKET---------NRKFYCQDIRAYDILFGDTPRPAQ-------------AED 202

  Fly   894 AHEDLDT-------EVSQINTQS---KTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPY 948
            .:|.||:       |..:||.:.   :.:.|...|...:|:||                    |.
Human   203 LYEILDSFTEKYENEGQRINARKAAREQRKSSAKELPPKPLSR--------------------PQ 247

  Fly   949 EATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFP--ATYVKVLQGGRNSGRNTPV 1011
            ::::..||              :||       ::..|.:...:|  ::|.:     |....|.|:
Human   248 QSSAPVQL--------------NSG-------SQSNRNEYKLYPGLSSYHE-----RVGNLNQPI 286

  Fly  1012 SGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEP--EWWRGELNGLSGLFPSNY 1074
                         :|.|||.::.|...:|:|...|.|:|:.:.:.  :||.|:|.|.:|:||:||
Human   287 -------------EVTALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANY 338

  Fly  1075 V 1075
            |
Human   339 V 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772	10/50 (20%)
		SH3_Intersectin_4	941..998	CDD:212773	8/58 (14%)
		SH3_Intersectin_5	1025..1077	CDD:212774	21/53 (40%)
SH3YL1	NP_056492.2	SYLF_SH3YL1_like	11..209	CDD:211401	27/135 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	218..266		13/88 (15%)
		SH3_SH3YL1_like	287..340	CDD:212775	21/53 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030