DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and SPAPJ696.02

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_593048.1	Gene:	SPAPJ696.02 / 2543305	PomBaseID:	SPAPJ696.02	Length:	430	Species:	Schizosaccharomyces pombe

Alignment Length:	486	Identity:	91/486 - (18%)
Similarity:	156/486 - (32%)	Gaps:	171/486 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   623 SVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPA----VDLGGPAPEGFVKYQAVYEFNA 683
            |..||..||......:.|:.:|| :.:..|..:|:...|    :.|||
pombe    80 SAPSAVMTGGMGVGAQIGSELTD-FVIILNSKAAVQTFARLGSITLGG----------------- 126

  Fly   684 RNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPV---- 744
                .::...|     ||.:|||.|. ...:.|....|..|..:.|..|     .::|..|
pombe   127 ----NLSIAAG-----PLGRNAEAGG-GASVGGMAPMFSYSKTKGLFAG-----VSLEGSVLVER 176

  Fly   745 -DAQVATVADTYNDNINTSSIPAASADLTAAGDVEYYI---AAYPYESAEEGDLSFSAGEMVMVI 805
             ||.    ...|..:|....:.:......||.|..|.:   ..:.....:|||:   ..::.:..
pombe   177 RDAN----RSLYRGDITAKRLLSGQVAQPAAADPLYRVLNSKIFNLNRGDEGDI---YNDVPIYA 234

  Fly   806 KKEGE--WWTGTIGSR---TGMFPSNYVQKADVGTASTAAAEP-----------VESLDQETTLN 854
            ..|.|  |...:..::   :....|:|.::.|...::.:.|..           .:||.::|
pombe   235 DDEPEDIWGPSSKSTKRRDSADRSSSYSRRGDSYRSNRSRAHDDDDEDDYSFSRSKSLSRKT--- 296

  Fly   855 GNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTE---VSQINTQSKTQSSEP 916
            ...:..::.::.:...|...|....|            .::.|.|.|   .|.::|:|.:|.|..
pombe   297 AGGSLRSSKMDNRRSKYADTPSPRRS------------RSYSDEDEESVYSSDVSTESSSQFSSR 349

  Fly   917 AESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQA 981
            :..||:| ||.::..|                                  :.|.||
pombe   350 SSEYSKP-SRPTAPKP----------------------------------KFKQDS--------- 370

  Fly   982 KGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDD 1046
                               .|.|..|                    |:|.:..:...:|||.|.|
pombe   371 -------------------LGPNQAR--------------------AMYSFAGEQPGDLSFQKGD 396

  Fly  1047 IISVLGR--DEPEWWRGELNGLSGLFPSNYV 1075
            ||.::.|  ...:||.|.:....|:||:|||
pombe   397 IIDIVERSGSHDDWWTGRIGYREGIFPANYV 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770	10/53 (19%)
		SH3_Intersectin_3	779..830	CDD:212772	9/58 (16%)
		SH3_Intersectin_4	941..998	CDD:212773	3/56 (5%)
		SH3_Intersectin_5	1025..1077	CDD:212774	19/53 (36%)
SPAPJ696.02	NP_593048.1	SYLF_SH3YL1_like	13..213	CDD:211401	36/169 (21%)
SPAPJ696.02	NP_593048.1	SH3_Ysc84p_like	375..429	CDD:212776	20/73 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030