DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and ucp8

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_595633.2	Gene:	ucp8 / 2540786	PomBaseID:	SPBC83.01	Length:	829	Species:	Schizosaccharomyces pombe

Alignment Length:	691	Identity:	133/691 - (19%)
Similarity:	244/691 - (35%)	Gaps:	196/691 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VTPRERLKYQEQFR--------ALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKM 66
            :.|.||.:|:::||        :.:|  |.:..:.||...|:|.|...:|.|||.|||:...|.:
pombe   125 INPDERSEYEKEFRENLRGHEDSARP--GCMPSSIAKPILLKSSLHYAVLAQIWNLADSAHVGYL 187

  Fly    67 NINEFSIA------CKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIV 125
            .:.::.||      ||..||    :.:|:.||..::.|...:.|:|
pombe   188 EMYQYVIARHLVAICKQYNL----IHLPRSLPADVIESAKSETPAM------------------- 229

  Fly   126 PAVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPT-------SNPPSRHTSISERAPSIESVNQG 183
                                   ..::..|.|.|:       |:..|..::.|.:...|.:.|..
pombe   230 -----------------------NTNIEQGVTQPSLVNTEQLSHQQSISSTKSSKLDEISADNNA 271

  Fly   184 EWAV-------------QA--------AQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQV 227
            :.||             ||        ..:..:.|:|:..|....||:.|.:|....:.|.|...
pombe   272 QSAVDNKYSSPPQTIDPQANIKALITPEDRSNFYQLFSKIDNENKGYIVGGEAVPFFMASHLDSE 336

  Fly   228 TLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVP--PNLRKIKSRPGSVSG 290
            .||:||...|....|.::.|||.:||.:.:..::|:.:...|..:..|  |.:::     ..||.
pombe   337 ELARIWDTVDTQDRGYIDKDEFAVAMEIIKLRLSGKSLASILAYDDNPTEPTMQQ-----NLVSD 396

  Fly   291 VVSRPGSQPASRHASVSSQSGVGVVDADPTAGL------------PGQNKRKENYVKGQAELDR- 342
            ..:...:.|.:......|...:.|.|.:|.:.|            |......||......:|..
pombe   397 DTNASTAVPVAFTNDNVSNVPLSVADNEPNSTLNLLASSDTAAFEPTAVSLHENPSSSLEDLQSA 461

  Fly   343 -RRKIMEDQQRKEREERERKEREEAD-------------------------------------KR 369
             :....:||...:.:.......:..:                                     |.
pombe   462 FQNTSFQDQVSTQNQANTADISQNTESGSSTQGQMFGIPPTTQSIPLKMAGFPGGVNSSLTDIKE 526

  Fly   370 EKARLEAERKQQEELERQLQRQREIEMEK----EEQRKRELEAKEA------ARKELEKQRQQE- 423
            |:|..|...:|:|....|::....|..|.    ||.:...|....|      ....|:.|:..|
pombe   527 EEAVSENAPQQEERSFEQIKTSIHIAPENISAIEESKSVPLPTSFATTIPGSTSAALDDQQTTEA 591

  Fly   424 --WEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVID 486
              .|....|....::|:|:.|.|::|..:|:..:|  |:....|.:.||              |:
pombe   592 PFEEPDEPAHEPTEEEQEEMRKLEEKIESTKYGLE--TIQTSGKTIKQR--------------IE 640

  Fly   487 GMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQER-AKWEAKSKASGAALGGENAQQEQLNAAFAH 550
            ..:|:......|:.:|.| |||:..|  |::|.. |..:..::.....:|.:.|.:|
pombe   641 QKKTRLMILREELQELDA-IKEEAQK--QISQSLIADQQLSTQIGSVGMGKKQAVKE-------- 694

  Fly   551 KQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELS 591
                :.:::.|:::|   |......:.|..|....:|.:::
pombe   695 ----LRKLQAKIDSI---IADSMSPMGTGAVNSPAIKPQVT 728

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	31/104 (30%)
		EH	18..83	CDD:238009	24/78 (31%)
		EH	184..279	CDD:197477	28/117 (24%)
		EH	195..261	CDD:238009	20/65 (31%)
		GBP_C	<366..467	CDD:303769	27/150 (18%)
		TACC	369..570	CDD:282818	45/214 (21%)
		coiled coil	432..443	CDD:293879	2/10 (20%)
		coiled coil	457..467	CDD:293879	2/9 (22%)
		TBPIP	<495..589	CDD:284512	19/94 (20%)
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
ucp8	NP_595633.2	EH	14..80	CDD:238009
		EH	124..223	CDD:197477	31/103 (30%)
		EH	133..204	CDD:238009	21/72 (29%)
		EH	304..370	CDD:238009	20/65 (31%)
		EF-hand_7	305..362	CDD:290234	18/56 (32%)
		UBA	790..826	CDD:197551
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9305
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1514
TreeFam	0	0.000	Not matched by this tool.
	4	4.010