DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and SPBC119.05c

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_595286.1	Gene:	SPBC119.05c / 2539945	PomBaseID:	SPBC119.05c	Length:	296	Species:	Schizosaccharomyces pombe

Alignment Length:	271	Identity:	65/271 - (23%)
Similarity:	110/271 - (40%)	Gaps:	69/271 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   651 SNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEIN 715
            ::.::|.||..|:...|.|  ..|.::..|..|.:      |...:..:.|.||:.
pombe    46 ASPVTAPAAQPVESSVPLP--LPKRKSSVEKRAGS------VASAVAAMSLSQNSG--------- 93

  Fly   716 GHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSS-----IPAASADLTAAG 775
                       ||....|...:..|.||.....|:       ::|:|:     .|:.....||..
pombe    94 -----------EKRTPEEPRKLPGVPAPQKQSEAS-------SVNSSTEKLPPPPSYPGPNTAHK 140

  Fly   776 DVEYYIAAYPYESAEEGDLSFSAGEMVMVIKK-EGEWWTGTIGSRTGMFPSNYVQKADVGTASTA 839
            :||..:|.|.:...:.|||.|.|||:::|::. ..:||.|.:..:.|:||||||:..:   .|..
pombe   141 NVERVLAMYDFPGPDAGDLGFHAGEVIIVLEHVNNDWWRGELNGKEGIFPSNYVRLLE---DSAV 202

  Fly   840 AAEPVESLDQETTLNGNAAYTAAPVEAQEQVY------------------QPLPVQEPSEQPISS 886
            .|:|.....|: .....|:.:|.|::.|:..|                  ||:.|.:|:|...||
pombe   203 KAQPPPPPPQQ-NYPPAASSSAPPMQYQQTAYPPQQAPYPPVQAYPQAPQQPIVVAQPTEHKHSS 266

  Fly   887 ------PGVGA 891
                  .|:|:
pombe   267 TFKKIGSGLGS 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770	7/53 (13%)
		SH3_Intersectin_3	779..830	CDD:212772	20/51 (39%)
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
SPBC119.05c	NP_595286.1	SH3	142..195	CDD:214620	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940