DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and Fnbp1l

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001108137.1	Gene:	Fnbp1l / 214459	MGIID:	1925642	Length:	609	Species:	Mus musculus

Alignment Length:	540	Identity:	99/540 - (18%)
Similarity:	192/540 - (35%)	Gaps:	150/540 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 NYVKGQAEL---DRRRKIMEDQQRKERE-ERERKEREEADKREKARLEAERKQQEELERQLQRQR 392
            |...||.|:   :...::..:..|...: :.|||...:..::.:..|:...||.:..:::.:|:.
Mouse    80 NDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFEREC 144

  Fly   393 EIEMEKEEQRKRELE-AKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHN------ 450
            . |.||.:|....|: ...|.:.::||.:||...:..:|:.|..:...|.:....:.|.
Mouse   145 R-EAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVI 208

  Fly   451 TQLNVELSTLNE----KIKELSQRICDT-RAGVTNVKTVIDGM-------RTQRDTSMSEMSQLK 503
            .|:..:|..::|    |:.|..:...|: |..:..:...::||       ..:||:.| .:...|
Mouse   209 PQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQM-VVDSFK 272

  Fly   504 ARIK-------EQNAKLLQLT----------QERAKWEAKS---KASGAA-LGGENAQQEQ---- 543
            :..:       |..::.:..|          ||..|.::||   ||.|.. |.|:..:.:.
Mouse   273 SGFEPPGDFPFEDYSQHIYRTISDGTISAAKQESGKMDSKSTVGKAKGKLWLFGKKPKPQSPPLT 337

  Fly   544 ---------------LNAAFAHKQLIINQIK---------------------DKVENIS------ 566
                           |..:.......:|:||                     ..:|:.|
Mouse   338 PTSLFTSSTPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSMKMGPALEDFSHLPPEQ 402

  Fly   567 --KEIESKKEDINTNDVQMSELKAELSALITKCEDLY-KEYDVQRTSVLELKYNRKNETSVSSAW 628
              |:::.:.:::|..    .:.:|:....:.|.:|:| |...:.....|:.|.............
Mouse   403 RRKKLQQRIDELNRG----LQKEADQKEALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRM 463

  Fly   629 DTGSSSAW--EETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKY---------------- 675
            :...:.||  |..|.|........|:||:.|    |..|..:|||  .|
Mouse   464 EIHKNEAWLSEVEGKTGIRGDRRHSSDINHL----VTQGRESPEG--SYTDDANQEVRGPPQQHG 522

  Fly   676 ---------------------QAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWL-AGEINGHT 718
                                 :|:|.|:..|...:....|:::.: :|::...||. |...||..
Mouse   523 HHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYI-IEEDKGDGWTRARRQNGEE 586

  Fly   719 GWFPESYV----EKLEVGEV 734
            |:.|.:|:    ||...|.|
Mouse   587 GYVPTTYIDVTLEKSSKGAV 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769	22/111 (20%)
		TACC	369..570	CDD:282818	50/288 (17%)
		coiled coil	432..443	CDD:293879	2/10 (20%)
		coiled coil	457..467	CDD:293879	3/13 (23%)
		TBPIP	<495..589	CDD:284512	22/162 (14%)
		SH3_Intersectin_1	674..728	CDD:212770	15/95 (16%)
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
Fnbp1l	NP_001108137.1	F-BAR_FNBP1L	5..256	CDD:153359	35/176 (20%)
		Interaction with CDC42. /evidence=ECO:0000250	245..535		48/300 (16%)
		HR1_CIP4_FNBP1L	399..479	CDD:212018	13/83 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..538		10/61 (16%)
		Interaction with DNM1. /evidence=ECO:0000250	522..605		16/83 (19%)
		Interaction with DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	541..605		16/64 (25%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000250	541..597		14/56 (25%)
		SH3_FNBP1L	541..597	CDD:213005	14/56 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030