DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and EPS15

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_016856104.1	Gene:	EPS15 / 2060	HGNCID:	3419	Length:	933	Species:	Homo sapiens

Alignment Length:	786	Identity:	171/786 - (21%)
Similarity:	298/786 - (37%)	Gaps:	246/786 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFS 72
            |||.|.::.||...|.:|.|..||::|.:.|...|.|:||..|||::|.|:|.|.||.::.:||:
Human   122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFA 186

  Fly    73 IACKLINLKLRGMDVPKVLPPSLLS-------SLTGDV----PSMTPRGSTSSLSPLDPLKGIVP 126
            :|..|:...|....||..|||:|:.       |::|.|    .|.:.:.|..||    |..||:|
Human   187 VAMFLVYCALEKEPVPMSLPPALVPPSKRKTVSISGSVRLIPSSASAKESYHSL----PSVGILP 247

  Fly   127 AVAPVVPVVAPPVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQ 191
            ..||:                                                   .:|.|..|:
Human   248 TKAPL---------------------------------------------------RQWVVSPAE 261

  Fly   192 KRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFL- 255
            |.||.::|...|:...|:::|.:.|.:.:::.||...||.||:|.|....|:|:.|:|.||..|
Human   262 KAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLI 326

  Fly   256 CEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPT 320
            .:|.:.|...|..|..|.:||:     .|......::   ||.|.:..:::.
Human   327 SQKLIKGIDPPHVLTPEMIPPS-----DRASLQKNII---GSSPVADFSAIK------------- 370

  Fly   321 AGLPGQNKRKENYVKGQAELDR-RRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEEL 384
                              |||. ..:|::.|:.|...|::.||:|:..|:..:.::   ..|:|:
Human   371 ------------------ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQ---DLQDEV 414

  Fly   385 ERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAH 449
            :|:....::::.:|  |:.:||      ..||::|:.|..||  :.|:..:...|.:.:...||.
Human   415 QRENTNLQKLQAQK--QQVQEL------LDELDEQKAQLEEQ--LKEVRKKCAEEAQLISSLKAE 469

  Fly   450 NTQLNVELSTLNEKI----KELS---QRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIK 507
            .|....::||..|::    :|||   |...:....|.:.|..::.::.....|..|:|.::.::.
Human   470 LTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLM 534

  Fly   508 EQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKD---------KVE 563
            |....                        || ...|||...:...:::|...|         :..
Human   535 EMKDL------------------------EN-HNSQLNWCSSPHSILVNGATDYCSLSTSSSETA 574

  Fly   564 NISKEIES----KKEDINTNDVQMS--EL-------KAELSALITKCEDLYKEYDVQRTSVLELK 615
            |:::.:|.    :.|.|:......|  ||       :.|::..:|  |.:..|.|..|.|..|..
Human   575 NLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVT--EKVCSELDNNRHSKEEDP 637

  Fly   616 YNRKNETSVSSAWDT-----------GSSSAWEETGTTV-----------------------TDP 646
            :|..:.:......||           ||....::....:                       |||
Human   638 FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDP 702

  Fly   647 YAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEIT----------FVPGDIILVPL 701
            :|.:|.|                          .|:|.|...||          |.||..::...
Human   703 FATSSTD--------------------------PFSAANNSSITSVETLKHNDPFAPGGTVVAAS 741

  Fly   702 EQNAEP 707
            :...:|
Human   742 DSATDP 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	38/99 (38%)
		EH	18..83	CDD:238009	25/64 (39%)
		EH	184..279	CDD:197477	33/95 (35%)
		EH	195..261	CDD:238009	22/66 (33%)
		GBP_C	<366..467	CDD:303769	22/104 (21%)
		TACC	369..570	CDD:282818	39/216 (18%)
		coiled coil	432..443	CDD:293879	1/10 (10%)
		coiled coil	457..467	CDD:293879	3/13 (23%)
		TBPIP	<495..589	CDD:284512	18/115 (16%)
		SH3_Intersectin_1	674..728	CDD:212770	9/44 (20%)
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
EPS15	XP_016856104.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154123
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840