DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and itsn-1

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001299978.1	Gene:	itsn-1 / 178491	WormBaseID:	WBGene00006405	Length:	1087	Species:	Caenorhabditis elegans

Alignment Length:	1211	Identity:	336/1211 - (27%)
Similarity:	531/1211 - (43%)	Gaps:	274/1211 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 WAVTPRERLKYQEQFRALQPQAGFVTGAQ-------AKGFFLQSQLPPLILGQIWALADTDSDGK 65
            |.|:..|   ||:.|...    |.:||.|       |:...::|.||..:|.|||||:|.|.||:
Worm     5 WEVSDAE---YQKNFAMF----GQLTGGQPFMDAVTARNALMRSNLPTQVLSQIWALSDLDKDGR 62

  Fly    66 MNINEFSIACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAP 130
            ::|.|:|||.:|....|.|:.:|..||||||.....:.|...|.....|:.....|
Worm    63 LDIREYSIAMRLALNCLAGIPIPPQLPPSLLVVPARNAPPTWPGSRHGSVDYSQTL--------- 118

  Fly   131 VVPVVAPPVAVATVISPPGVS-------VPSGPTPPTSNPPSRHTSISERAP--SIESVNQG--- 183
                            ||.:.       :||.|......|.|||.|||..:|  :..:|.:|
Worm   119 ----------------PPAIDRRMSQSYIPSAPVSIAGTPSSRHNSISAGSPLNNDRNVFEGRQL 167

  Fly   184 -EWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCD 247
             .||:....|.||:|:|||.|:.|.|.|:....|..|..|.||...||.||.|||::.||:|:.|
Worm   168 ENWAIPHHNKLKYSQLFNALDKERLGSLSSQVGRSALGLSGLPTNVLAHIWFLSDVNKDGKLSVD 232

  Fly   248 EFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGV 312
            |:.::.::.|...:|..:|...|.|.|                           |...:||:|..
Worm   233 EYAISQYMIEMFKSGFALPKITPLELV---------------------------RMCGISSRSAN 270

  Fly   313 GVVDADPTAGLPG--------QNKRKENYVKGQAELDRRRKIMEDQQRKEREERERKEREEADKR 369
            ...:.:|.|..|.        ::||::|..||||||:|||:::|:::::.|.|.|:|||||..|:
Worm   271 NTPELEPGAEPPQKSPAPKTFEDKRQDNLSKGQAELERRRRVLEEEEQRRRAEVEKKEREEEAKK 335

  Fly   370 EKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNA 434
            .:.|.|.||:.:.|.:.:|:|||.||.::||:.|:.....|..|:|.||.|:.:.|:|::.:|..
Worm   336 NRERQEKERQAEVERQAELERQRIIEAQREEEEKKRRLEMERRREEDEKMRKVQMEKAKVKQMQN 400

  Fly   435 QKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEM 499
            ||::|.||:.:::.....|..:|..|:||:.::...|...:..|..|...|:.||:.||..:
Worm   401 QKQQENERLAQRQQREKTLQFQLQALDEKVIDVEVDIGKAKEAVAEVTGFIERMRSTRDEKV--- 462

  Fly   500 SQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVEN 564
                |||||     ||.|.::.:...:|:    .||.:..|::..:.....::..:..::.|.:.
Worm   463 ----ARIKE-----LQETNQKFQTAIESQ----ELGHQLLQKQSAHKETTQRKSELEALRRKRDA 514

  Fly   565 ISKEIESKKEDINT------NDVQMSELKAE------LSALITKCEDLYKEYDV-------QRTS 610
            |.|.||....:::|      |..::.:...|      .|.|:.|.|:....:::       .|:.
Worm   515 IRKAIEDAALELSTEKEKSYNQTEILKTNKEKYKTDVYSKLVAKREEYRNSFELLVHAQTHARSK 579

  Fly   611 VLELK-------------------------------YNRKNETSVSSAWDTGSSSAWEETGTTVT 644
            :.|.:                               :...::|..|..:|....:      |:..
Worm   580 IGEFEAKSAPASAAPAPAPAPAPTTTNGFPANFNDAFGEFDKTDASQRFDADFGA------TSTA 638

  Fly   645 DPYAVASNDISALAAPAVDLGGPAPEGF-----VKYQAVYEFNARNAEEITFVPGDIILVPLEQN 704
            ||:|..:.      |||...|......|     .|.:|::.|.||:.:|::|.|||:|:|.....
Worm   639 DPFAQIAQ------APAHSKGAVDQSAFNIHDTYKCRALFAFEARSEDELSFEPGDVIIVFQSHA 697

  Fly   705 AEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAP------------------VD------ 745
            |||||.||::....|||||::||        .:|||..|                  ||
Worm   698 AEPGWRAGQLREKVGWFPEAFVE--------AIAAVPTPGGDPPIQNMPPNMTPSSSVDQIGVKA 754

  Fly   746 AQVATVADTYNDNINTSSIPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGE 810
            |:.|.:|...  .:.....|.||:...||..:...||.:.:.:..|.||||:.|:.:.|::|:..
Worm   755 ARKAEIAAAM--GLTEGGAPPASSAPAAAAVISQCIAQFQWRARNEEDLSFAKGDTIEVLEKQEM 817

  Fly   811 WWTG-TIGSRTGMFPSNYVQ----------------KADVGTASTAAAEPVESLDQETTLNGNAA 858
            .|.| ......|.||.:||:                ||..|....||....:.:..:.||.   |
Worm   818 KWKGRNPAGEIGWFPKSYVKEVGATTSTTTPIVSPSKASAGAPGAAAGAQYDVVPSDVTLQ---A 879

  Fly   859 YTAAPVEAQEQVYQPLPVQEPSEQPISSPGVG----AEEAHED------------LDTEVSQINT 907
            ...||   |:|:|..:...|..|....:..||    ..|.:::            ......:|:.
Worm   880 SETAP---QQQLYTVIYDFEAVETTDLALHVGDTILVLEKNDEWWKGRCNGREGIFPANYVEISV 941

  Fly   908 QSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDS 972
            |   |:.:|......|   |.:..|.:..:    |:|:..:.|::..||.:..|:::.||:|:.:
Worm   942 Q---QAGDPTPPTQAP---TPAAPPTVLCE----AKVVVDFVASAPNQLGIKVGEIVKIREKSAA 996

  Fly   973 GWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQND 1037
            |||||||...| :...||||..|||||:...     :|.:            :..|:|.|:|...
Worm   997 GWWEGELIRNG-KPIAGWFPGEYVKVLEEAA-----SPAT------------RATAVYDYEASQP 1043

  Fly  1038 DELSFDKDDIISVLGRDEPEWWRGELN---GLSGLFPSNYV 1075
            |||.|...|:|.|..:.|.|||.|...   ..|||||||||
Worm  1044 DELGFKTGDVIIVTDKSEAEWWSGHREQDPSKSGLFPSNYV 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	39/99 (39%)
		EH	18..83	CDD:238009	27/71 (38%)
		EH	184..279	CDD:197477	36/94 (38%)
		EH	195..261	CDD:238009	27/65 (42%)
		GBP_C	<366..467	CDD:303769	34/100 (34%)
		TACC	369..570	CDD:282818	56/200 (28%)
		coiled coil	432..443	CDD:293879	5/10 (50%)
		coiled coil	457..467	CDD:293879	4/9 (44%)
		TBPIP	<495..589	CDD:284512	19/99 (19%)
		SH3_Intersectin_1	674..728	CDD:212770	25/53 (47%)
		SH3_Intersectin_3	779..830	CDD:212772	17/67 (25%)
		SH3_Intersectin_4	941..998	CDD:212773	23/56 (41%)
		SH3_Intersectin_5	1025..1077	CDD:212774	25/54 (46%)
itsn-1	NP_001299978.1	EH	4..93	CDD:197477	37/94 (39%)
		EH	12..80	CDD:238009	27/71 (38%)
		EH	169..259	CDD:197477	35/89 (39%)
		EH	180..246	CDD:238009	27/65 (42%)
		DUF4515	387..578	CDD:291649	45/206 (22%)
		LCD1	390..>429	CDD:286837	11/38 (29%)
		ATP-synt_B	<423..544	CDD:304375	31/136 (23%)
		SH3_Intersectin_1	667..721	CDD:212770	26/61 (43%)
		SH3_Intersectin_2	786..838	CDD:212771	17/51 (33%)
		SH3	889..938	CDD:214620	6/48 (13%)
		SH3_Intersectin_4	965..1021	CDD:212773	23/60 (38%)
		SH3	1028..1085	CDD:214620	26/69 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159902
Domainoid	1	1.000	139	1.000	Domainoid score	I2982
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2277
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1082
Isobase	1	0.950	-	0	Normalized mean entropy	S4783
OMA	1	1.010	-	-		QHG45992
OrthoDB	1	1.010	-	-		D349276at33208
OrthoFinder	1	1.000	-	-		FOG0002286
OrthoInspector	1	1.000	-	-		oto18767
orthoMCL	1	0.900	-	-		OOG6_103215
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X1514
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890