DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and B0303.7

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_498918.3	Gene:	B0303.7 / 176220	WormBaseID:	WBGene00015128	Length:	493	Species:	Caenorhabditis elegans

Alignment Length:	636	Identity:	129/636 - (20%)
Similarity:	223/636 - (35%)	Gaps:	192/636 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   471 ICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKA------RIKEQNAKLLQLTQERAKWEAKS-- 527
            ||.| :|.:|      |:....|||...:|..||      |.:.:||.:........:..||:
Worm    15 ICGT-SGNSN------GINENIDTSTFSVSAAKALFESAKRPEVRNAAIAAAKNPFVRQTAKNVA 72

  Fly   528 ---KASGAALGGENAQQE-----QLNAAFAHKQLIINQIKDKVENISKEIESKKEDI------NT 578
               ||.||.|   ||.::     :::||||        :.|         .::|.|.      :.
Worm    73 QDEKARGAVL---NAVKDPSGGNKISAAFA--------VAD---------ANRKSDSVPPPPPHR 117

  Fly   579 NDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTV 643
            ......:|....||:.::.|:::....|..:          |.::.:.::.:.|:|::..:....
Worm   118 GGTSPGKLSGSHSAIRSQLENMHIGGSVMSS----------NSSTATPSYQSNSTSSYSSSAPVA 172

  Fly   644 TDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPG 708
            ..|....:..|.:.:|||:.    .|.|..|    :::....::|:....||.:|:..:.:||
Worm   173 PPPVPRHTQSIPSYSAPAIS----TPYGIAK----FDYAPTQSDEMGLRIGDTVLISKKVDAE-- 227

  Fly   709 WLAGE-INGHT-GWFPESYVE-KLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAASAD 770
            |..|| .|..| |..|.||:: |:.:.|.                          .:::|...|.
Worm   228 WFYGENQNQRTFGIVPSSYLDIKIPLKEA--------------------------FTALPPRPAA 266

  Fly   771 LTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKK-EGEWWTGTIGSRTGMFPSNYVQKADVG 834
            .:.:....|..|.|.|.|.|.|||:|:.|..:||..: ..||..|....|:|:|||.:|.
Worm   267 PSGSSSGTYATAIYDYNSNEAGDLNFAVGSQIMVTARVNEEWLEGECFGRSGIFPSQFVD----- 326

  Fly   835 TASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQ-PLPVQEPSEQPISSPGVGAEEAHEDL 898
                                       .|     .:|| |:....||..|
Worm   327 ---------------------------CP-----NLYQVPMKQSAPSSAP--------------- 344

  Fly   899 DTEVSQINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQL 963
                                |||.|::..|.        ..:...|...|::.....|.|..|.:
Worm   345 --------------------SYSHPITNNSG--------PKQTVTVSYDYDSGVASDLRLFEGDV 381

  Fly   964 IMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIA 1028
            |...:..|:.|...|.     |.|.|..|.|::....|   |.:..|..|...........|.:|
Worm   382 ITALEDIDAQWLLAEC-----RGQQGMVPKTFLGPPYG---SPKKAPSKGIAEIACAFSPKKAVA 438

  Fly  1029 LYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGL----SGLFPSNYV 1075
            ...|.:::...|...:.|.:.::...:..:::|:|...    :|:.|.|.|
Worm   439 TGDYHSEDPKHLYVTRGDHLLIVEDVDDYYYKGKLEAFKTLPAGILPKNIV 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818	29/114 (25%)
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512	24/115 (21%)
		SH3_Intersectin_1	674..728	CDD:212770	16/56 (29%)
		SH3_Intersectin_3	779..830	CDD:212772	22/51 (43%)
		SH3_Intersectin_4	941..998	CDD:212773	14/56 (25%)
		SH3_Intersectin_5	1025..1077	CDD:212774	11/55 (20%)
B0303.7	NP_498918.3	SH3	194..247	CDD:214620	17/58 (29%)
		SH3	275..326	CDD:302595	21/50 (42%)
		SH3	356..409	CDD:214620	14/57 (25%)
		SH3	432..490	CDD:214620	11/58 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940