DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dap160 and Itsn1

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	XP_006522994.1	Gene:	Itsn1 / 16443	MGIID:	1338069	Length:	1743	Species:	Mus musculus

Alignment Length:	1484	Identity:	436/1484 - (29%)
Similarity:	665/1484 - (44%)	Gaps:	469/1484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 AVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNI 68
            ::|.||:|..||.|:.:||.:|:|.|||:||.||:.||.||.||..:|.|||||||.::||:|:.
Mouse    35 SLDVWAITVEERAKHDQQFLSLKPIAGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQ 99

  Fly    69 NEFSIACKLINLKLRGMDVPKVLPPSL------LSSL----TGDVPSMTPRGSTSSLSPLD---- 119
            .|||||.|||.|||:|..:|..|||.:      :||.    .|.:.||.|   .::::|:.
Mouse   100 VEFSIAMKLIKLKLQGYQLPSTLPPVMKQQPVAISSAPAFGIGGIASMPP---LTAVAPVPMGSI 161

  Fly   120 PLKGI-VPAVAPVVPVVAPPVA--VATVISP------PGVSVPSGPTPPTSNPPSRHTSISERAP 175
            |:.|: .|.|:.|.|...||:|  ...||.|      |..::|...:...|.|.|:..:..::|.
Mouse   162 PVVGMSPPLVSSVPPAAVPPLANGAPPVIQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQ 226

  Fly   176 SIESVN---QGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSD 237
            |.:..:   ..||||..:.:.||.|:||::|:|.||:|||.|||.:|:||.|||..||.||.|||
Mouse   227 SFDVASAPPAAEWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSD 291

  Fly   238 IDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSRPG----SVSGVVSRPGSQ 298
            ||.||:|..:||||||.|.:.||:|:.:|..||.|::||:.|:::|..|    |.|.|..|...:
Mouse   292 IDQDGKLTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGMSVISSSSVDQRLPEE 356

  Fly   299 PASRHASVSSQSGVGVVDADPTAGLP--GQNKRKENYVKGQAELDRRRKIMEDQQRKEREERERK 361
            |:|..            :..|...||  .::|::||:.:|..||::||:.:.:|||||:|...:.
Mouse   357 PSSED------------EQQPEKKLPVTFEDKKRENFERGSVELEKRRQALLEQQRKEQERLAQL 409

  Fly   362 EREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAKEAARKELEKQRQQEWEQ 426
            ||.|.:::|:.|.|.|||:|.|||:||::|||:|.::||:|::|:|.:|||::|||:|||.|||:
Mouse   410 ERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWER 474

  Fly   427 ARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQ 491
            .|..|:..|:.:|||..:..||....|..||..||:|..:|..::.|.|..:...:..|:.....
Mouse   475 NRRQELLNQRNKEQEGTVVLKARRKTLEFELEALNDKKHQLEGKLQDIRCRLATQRQEIESTNKS 539

  Fly   492 RDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQ----------LNA 546
            |:..::|::.|:.:::|....|.:|..|:           ..|..:..|.:|          |..
Mouse   540 RELRIAEITHLQQQLQESQQMLGRLIPEK-----------QILSDQLKQVQQNSLHRDSLLTLKR 593

  Fly   547 AFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSV 611
            |...|:|...|::::::.:.:|..||.::|:..:.|:.||:           :::.:..:|:...
Mouse   594 ALEAKELARQQLREQLDEVERETRSKLQEIDVFNNQLKELR-----------EIHSKQQLQKQRS 647

  Fly   612 LE-LKYNRKNETSVSSAWDTGSSSA----------W-----EETGTTVTDPY---------AVAS 651
            || .:..:|.:...|...:.....|          |     :|.......|:         :|..
Mouse   648 LEAARLKQKEQERKSLELEKQKEDAQRRVQERDKQWLEHVQQEEQPRPRKPHEEDRLKREDSVRK 712

  Fly   652 NDISALAAPAVD---------------LGGPAP-----EG-----------FVKYQAVYEFNARN 685
            .:....|.|.:.               |...||     :|           .|.|:|:|.|.:|:
Mouse   713 KEAEERAKPEMQDKQSRLFHPHQEPAKLATQAPWSTTEKGPLTISAQESVKVVYYRALYPFESRS 777

  Fly   686 AEEITFVPGDIILVPLE-----QNAEPGWLAGEINGHTGWFPESYVEKLEVGEV----------- 734
            .:|||..||||::|..|     |..|||||.||:.|.|||||.:|.||:...||
Mouse   778 HDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEKIPENEVPTPAKPVTDLT 842

  Fly   735 ---APVAAVE---APVDAQVATVADTYN-------------------DNINT------SSIPAAS 768
               ||..|:.   ||:....:..:.|.|                   ||.:|      .::|:|.
Mouse   843 SAPAPKLALRETPAPLPVTSSEPSTTPNNWADFSSTWPSSSNEKPETDNWDTWAAQPSLTVPSAG 907

  Fly   769 --------ADLTAAG-------------------------------------DV----------- 777
                    ...||.|                                     ||
Mouse   908 QLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKSDVITVLEQQDMWW 972

  Fly   778 ------------------------------------------------------EYYIAAYPYES 788
                                                                  |.:||.|.|||
Mouse   973 FGEVQGQKGWFPKSYVKLISGPVRKSTSIDTGPTESPASLKRVASPAAKPAIPGEEFIAMYTYES 1037

  Fly   789 AEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGTASTAAAEPVESLDQETTL 853
            :|:|||:|..|::::|.||:|:|||||:|.::|:||||||:..|
Mouse  1038 SEQGDLTFQQGDVIVVTKKDGDWWTGTVGDKSGVFPSNYVRLKD--------------------- 1081

  Fly   854 NGNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQINTQSKTQSSEPAE 918
                                            |.|.|                |..||
Mouse  1082 --------------------------------SEGSG----------------TAGKT------- 1091

  Fly   919 SYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGWWEGELQAKG 983
                          |...|:.|||||||.|.||..|||:|..||||:||||...|||||||||:|
Mouse  1092 --------------GSLGKKPEIAQVIASYAATGPEQLTLAPGQLILIRKKNPGGWWEGELQARG 1142

  Fly   984 RRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPYKAQNDDELSFDKDDII 1048
            ::||||||||.|||:|..|  :.:.||....:..:...:. :||.:|.|.|||||||:|.|..||
Mouse  1143 KKRQIGWFPANYVKLLSPG--TSKITPTELPKTAVQPAVC-QVIGMYDYTAQNDDELAFSKGQII 1204

  Fly  1049 SVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTSEIKPDPGACS------------RRSKG-IQRL 1100
            :||.:::|:||:||::|..||||||||.  :|:::.|....||            |:.:| |..|
Mouse  1205 NVLNKEDPDWWKGEVSGQVGLFPSNYVK--LTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHEL 1267

  Fly  1101 ---------------------------------------WQQWRGCDIDQAAQHGDASNNKLRGI 1126
                                                   |::...|:|.               :
Mouse  1268 IVTEENYVNDLQLVTEIFQKPLTESELLTEKEVAMIFVNWKELIMCNIK---------------L 1317

  Fly  1127 IQAVHITKRRDGQLMGC---------------AYVRFECNELLAKSMLQENGNQ 1165
            ::|:.:.|:..|:.|..               .|:||...:|...:::|:..::
Mouse  1318 LKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSCQLNGAALIQQKTDE 1371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	52/103 (50%)
		EH	18..83	CDD:238009	38/64 (59%)
		EH	184..279	CDD:197477	53/94 (56%)
		EH	195..261	CDD:238009	40/65 (62%)
		GBP_C	<366..467	CDD:303769	47/100 (47%)
		TACC	369..570	CDD:282818	67/210 (32%)
		coiled coil	432..443	CDD:293879	4/10 (40%)
		coiled coil	457..467	CDD:293879	4/9 (44%)
		TBPIP	<495..589	CDD:284512	21/103 (20%)
		SH3_Intersectin_1	674..728	CDD:212770	29/58 (50%)
		SH3_Intersectin_3	779..830	CDD:212772	29/50 (58%)
		SH3_Intersectin_4	941..998	CDD:212773	41/56 (73%)
		SH3_Intersectin_5	1025..1077	CDD:212774	31/51 (61%)
Itsn1	XP_006522994.1	EH	39..132	CDD:197477	50/92 (54%)
		PLN02983	<155..226	CDD:215533	18/70 (26%)
		EH	238..333	CDD:197477	53/94 (56%)
		PTZ00121	<355..739	CDD:173412	107/417 (26%)
		SH3	766..825	CDD:388381	29/58 (50%)
		INTAP	825..939	CDD:374674	18/113 (16%)
		SH3_Intersectin1_2	939..990	CDD:212922	2/50 (4%)
		SH3_Intersectin1_3	1028..1079	CDD:212924	29/50 (58%)
		SH3_Intersectin1_4	1096..1160	CDD:212926	45/63 (71%)
		SH3_Intersectin1_5	1180..1233	CDD:212928	31/55 (56%)
		RhoGEF	1260..1443	CDD:238091	15/127 (12%)
		PH_13	1462..1615	CDD:374702
		C2_Intersectin	1604..1738	CDD:176021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844364
Domainoid	1	1.000	176	1.000	Domainoid score	I3602
eggNOG	1	0.900	-	-		E1_KOG1029
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2277
Inparanoid	1	1.050	578	1.000	Inparanoid score	I1028
Isobase	1	0.950	-	0	Normalized mean entropy	S4783
OMA	1	1.010	-	-		QHG45992
OrthoDB	1	1.010	-	-		D349276at33208
OrthoFinder	1	1.000	-	-		FOG0002286
OrthoInspector	1	1.000	-	-		otm43468
orthoMCL	1	0.900	-	-		OOG6_103215
Panther	1	1.100	-	-	LDO	PTHR11216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	1	1.000	-	-		X1514
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750