Protein Alignment Dap160 and Dap160

DIOPT Version :10

• Sequence 1: NP_001246118.1
• Gene: Dap160 / 35378
• FlyBaseID: FBgn0023388
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: XP_061510972.1
• Gene: Dap160 / 1279996
• VectorBaseID: AGAMI1_013623
• Length: 1187
• Species: Anopheles gambiae
• Alignment Length: 1235
• Identity: 673/1235 - (54%)
• Similarity: 809/1235 - (65%)
• Gaps: 215/1235 - (17%)

  Fly     3 SAVDAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMN 67
            :|.|.:.:|.||||||::||::|||..|.|||.|||||||||||||.||||||||||||:||:|.
Mosquito     2 NASDPFVITSRERLKYEDQFKSLQPVDGVVTGGQAKGFFLQSQLPPQILGQIWALADTDADGRMT 66

  Fly    68 INEFSIACKLINLKLRGMDVPKVLPPSLLSSLT--GDVPSMTPRGSTSSLSPLDPLK------GI 124
            :.|||||||||||||||.:|||.|||:|::|||  |..|.:||   ||.||||||||      |:
Mosquito    67 LGEFSIACKLINLKLRGFEVPKALPPTLIASLTAVGGTPILTP---TSGLSPLDPLKSLSGSIGV 128

  Fly   125 VP---------------------------------------AVAPVVPVVAPPVAVATVISPP-- 148
            ||                                       .|.|..|.:.|.:..|:...||
Mosquito   129 VPQPQPPLMAPHAVPHAIVPPLMNNQMGVAPQTVVPGMGPGGVPPPKPALPPQLIAASAAGPPLI 193

  Fly   149 ---------------------------------------------------------GVSVPSGP 156
                                                                     ||:||:.|
Mosquito   194 PMGQPLIPGMAAPVQAAVMQQPLIGGLVGSAPTIPPTAAVKPLIDPLGSVSAVPLVGGVAVPAPP 258

  Fly   157 TPPTS--NPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVL 219
            |||.|  ..|:|..||||.||||||..|.|||::...|.||||:||..||.|||:|||.|||.::
Mosquito   259 TPPHSGGGTPARSMSISEWAPSIESPGQIEWAIKGPAKLKYTQLFNTTDRNRSGFLTGPQARNIM 323

  Fly   220 VQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQEWVPPNLRKIKSR 284
            ||:||||..|||||.|:|:|.||||.|:||:|||:||:.|.||||:|.|||.|.|||:.||..||
Mosquito   324 VQTKLPQAMLAQIWALADMDTDGRLGCEEFVLAMYLCDMAAAGEKVPTTLPPELVPPSFRKATSR 388

  Fly   285 PGSVSGVVSRPGSQPASRHASVSSQSGV--GVVDADPTAGLPG---QNKRKENYVKGQAELDRRR 344
            .|||.|          |||.|||||...  ..|:.||.:|||.   ::|||||:.||||||:|||
Mosquito   389 HGSVVG----------SRHGSVSSQGAPVHAAVELDPLSGLPQSSFEDKRKENFDKGQAELERRR 443

  Fly   345 KIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIEMEKEEQRKRELEAK 409
            |.:.|.|:||:||||||||||.:|..||:||||.|:|:|||::||||||:|.|:|||||||||.|
Mosquito   444 KALMDIQKKEQEERERKEREEQEKIRKAKLEAELKKQQELEKELQRQRELEQEREEQRKRELEKK 508

  Fly   410 EAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDT 474
            |.||||:|||||.|||..:||||...::||||.|||.||.|..|:|||||.||:||||||:||||
Mosquito   509 ELARKEMEKQRQLEWETQKIAEMQQHRQREQENVLKLKAQNQSLSVELSTFNERIKELSQKICDT 573

  Fly   475 RAGVTNVKTVIDGMRTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENA 539
            |.||||||:.||||||.|||.|:||:||||::||||.:|:||:||:||.:||||:      ||..
Mosquito   574 RVGVTNVKSTIDGMRTTRDTQMAEMTQLKAQVKEQNQRLVQLSQEKAKLDAKSKS------GETE 632

  Fly   540 QQEQLNAAFAHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAELSALITKCEDLYKEY 604
            .|.|    |.:||::|.|:|||:||..::||:|..|||.|..|:.|||::|:.||..||.||.||
Mosquito   633 SQLQ----FTNKQIVIQQLKDKLENTKQQIENKTTDINLNRDQLVELKSQLTDLIDACEQLYGEY 693

  Fly   605 DVQRTSVLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLGG--- 666
            |:||..:||:|.||||| |.||||||  |::|....||.|.   .|.|...|..|.:|..|.
Mosquito   694 DMQRIQILEMKNNRKNE-SYSSAWDT--SNSWGAPDTTTTH---AALNSEPAAPAASVTAGSGED 752

  Fly   667 -PAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEK-- 728
             ..|.|:|||:|:|||:|||::||:|.||||::||||||||||||||||||||||||||:|||
Mosquito   753 VQTPPGYVKYRAIYEFSARNSDEISFQPGDIVMVPLEQNAEPGWLAGEINGHTGWFPESFVEKVD 817

  Fly   729 --LEVGEVAP--VAAVEAPVD----------------AQVATVADTY---NDNINTSSIPAASAD 770
              |.|.|..|  :|..|..||                |..|.|.:.|   |||          .:
Mosquito   818 SNLNVVEAVPETIAYSEPEVDYTTTTTTTATTIAASAAAAAPVEEEYHAPNDN----------TE 872

  Fly   771 LTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQKADVGT 835
            .|..||||||:|.|.|:|||.|||.|.|||.:.|.||||:|||||||:|||:||||||||
Mosquito   873 ATCNGDVEYYVACYAYQSAEAGDLVFDAGETIAVSKKEGDWWTGTIGNRTGIFPSNYVQK----- 932

  Fly   836 ASTAAAEPVESLDQETTLNGN-AAYTAAPVEAQE----QVYQPLPVQEPSEQPISSPGVG----- 890
                        .:...:||| |.|...|...||    |..||...::.:::..|:....
Mosquito   933 ------------HEGEVMNGNQATYNEQPTMHQEPEQQQQQQPQAYEQETKRKQSAAAAAGNTQD 985

  Fly   891 AEEAHE--DLDTEVSQINTQSKTQSSEPAES--YSRPMSRTSSMTPGMRAKRSEIAQVIAPYEAT 951
            ||:|..  :.|:||||||||..:.:|...|:  || .||.||: ||.:| ::.|:||||||||||
Mosquito   986 AEDARNQAEADSEVSQINTQPPSGASANEENIRYS-SMSMTSA-TPSLR-RKGEVAQVIAPYEAT 1047

  Fly   952 STEQLSLTRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRI 1016
            |:|||||.||||||||||||||||||||||||||||||||||||||:||||||||||||||.|::
Mosquito  1048 SSEQLSLQRGQLIMIRKKTDSGWWEGELQAKGRRRQIGWFPATYVKILQGGRNSGRNTPVSASKV 1112

  Fly  1017 EMTEQILDKVIALYPYKAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGPFVTS 1081
            |:||.|||||||||||||.|||||||:||||||||||||||||||||||.:||||||||||||:|
Mosquito  1113 ELTETILDKVIALYPYKALNDDELSFEKDDIISVLGRDEPEWWRGELNGTTGLFPSNYVGPFVSS 1177

  Fly  1082  1081
            Mosquito  1178  1177

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	69/95 (73%)
		EH	184..279	CDD:197477	60/94 (64%)
		SMC_prok_B	<368..>615	CDD:274008	152/246 (62%)
		SH3_Intersectin_1	674..728	CDD:212770	43/53 (81%)
		SH3_Intersectin_3	779..830	CDD:212772	36/50 (72%)
		SH3_Intersectin_4	941..998	CDD:212773	53/56 (95%)
		SH3_Intersectin_5	1025..1077	CDD:212774	47/51 (92%)
		RRM_SF	<1125..1175	CDD:473069
Dap160	XP_061510972.1	None