Protein Alignment Dap160 and eps15

DIOPT Version :9

• Sequence 1: NP_001246118.1
• Gene: Dap160 / 35378
• FlyBaseID: FBgn0023388
• Length: 1190
• Species: Drosophila melanogaster
• Sequence 2: NP_001120100.2
• Gene: eps15 / 100145116
• XenbaseID: XB-GENE-6070905
• Length: 976
• Species: Xenopus tropicalis
• Alignment Length: 1025
• Identity: 237/1025 - (23%)
• Similarity: 382/1025 - (37%)
• Gaps: 335/1025 - (32%)

  Fly     8 WAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEFS 72
            |||.|.|:.||...|.:|.|..||::|.:.|...|.|:|...|||::|.|:|.|.||.::.:||:
 Frog   120 WAVKPDEKAKYDAIFDSLNPVNGFLSGDKVKPVLLNSKLSVEILGRVWELSDIDHDGLLDRDEFA 184

  Fly    73 IACKLINLKLRGMDVPKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPVVPVVAP 137
            :|..|:...|....||..||.:|       ||....:.|.||.|            .||:|.:..
 Frog   185 VAMFLVYSALEKEPVPMSLPHTL-------VPQSKRKVSISSAS------------LPVIPTLPM 230

  Fly   138 PVAVATVISPPGVSVPSGPTPPTSNPPSRHTSISERAPSIESVNQGEWAVQAAQKRKYTQVFNAN 202
            |        |...|..|  .||....|::             |...:|.|..|:|.|..::|:..
 Frog   231 P--------PSKESRQS--LPPVGILPTK-------------VQVTQWVVSHAEKTKCDELFHKL 272

  Fly   203 DRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAM-FLCEKAMAGEKIP 266
            |:...|.::|.:.|.:.:::.||.|.||.||||.|....|:|:.::|.||. |:.:|.:.|...|
 Frog   273 DKDMDGLVSGLEVREIFLKTGLPSVLLAHIWTLCDTKDCGKLSKEQFALAFHFINQKIVKGVDPP 337

  Fly   267 VTLPQEWVPPNLRKIKSRPGSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKRKE 331
            ..|..|.:||:.|...::..:.|..|                        ||.:|
 Frog   338 RVLTPEMMPPSERNAATKVPTASSPV------------------------ADFSA---------- 368

  Fly   332 NYVKGQAELDR-RRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELERQLQRQREIE 395
              :|   |||. ..:|:|.|:.|...|:|..|:|:|   .|.|....:..|:|:||:....:.::
 Frog   369 --IK---ELDSLNNEIVELQREKTSVEQELSEKEDA---VKCRTGEVQDLQDEVERETINLQNLK 425

  Fly   396 MEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTL 460
            .:|:|                        .|..:||::.||              .:|..:|..|
 Frog   426 SQKQE------------------------VQEILAELDEQK--------------AKLESQLQEL 452

  Fly   461 NEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQLKARI----------KEQNAKLLQ 515
            ..|..|.:|.|...:..:|..:|.|.....:...:.||:::|:...          |::.|.|.|
 Frog   453 RLKCAEETQMIASLKVEITTQETQISNYEDELSKAKSELNRLQEETILLEENLETGKQRLAPLEQ 517

  Fly   516 LTQE--------RAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKD--KVENISKEIE 570
            ..||        :||.| :.|||      || ..||||  :.|.  ::|.|.|  .:.|.|.|..
 Frog   518 QLQESKLEICSVQAKLE-ELKAS------EN-NVEQLN--WCHH--LVNGIGDHSSLSNSSSEPT 570

  Fly   571 SKKEDINTNDVQMSELKAELSALITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSA 635
            :..|:                   |.| |...:.|.|         :|.:....|...:..|.|.
 Frog   571 NLHEN-------------------TGC-DSPGQLDHQ---------SRSSPVRSSPEINQTSGSD 606

  Fly   636 WEETGTTV------------TDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEE 688
            .||....|            .|||     |::.:|.|:..:..|..:.|              :.
 Frog   607 GEEKDDNVNALVPQKEVSFQVDPY-----DVNPVAPPSAPVQDPGLDFF--------------QS 652

  Fly   689 ITFVPGDIILVPLEQNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVAD 753
            ..||..|    |.:.:                         ..|::.|..             .|
 Frog   653 DPFVGSD----PFKDD-------------------------PFGKIDPFG-------------GD 675

  Fly   754 TYNDNINTSS---IPAASADLTAAGDVEYYIAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGT 815
            .:.|:...:|   ...||||..|:..|         :|::| || ||        |.:.:.:|
 Frog   676 PFKDSDPFASDVFFKQASADPFASSKV---------DSSKE-DL-FS--------KSKADSFT-- 719

  Fly   816 IGSRTGMFPSNYVQKADVGTASTA------AAEPVESLDQETTLNGNAAYTAAPVE---AQEQVY 871
             .|....|.|:   ||:..|:|.|      :|:|.:|.:|:       .:|:|.|:   |.|..:
 Frog   720 -SSNADPFVSS---KAESLTSSKADPFQPSSADPFKSSEQD-------PFTSAKVDPFLATESTF 773

  Fly   872 QPLPVQEPSEQPIS-----SPG---------VGAEE------AHEDLDTEVSQINTQSKTQSSEP 916
            .       ||..:.     :||         .|:|:      ..|.:.|..:..:..||| |::.
 Frog   774 S-------SEDTLKNNDPFAPGGTVVSAVSESGSEDPFASFFGSESIGTGFADFSLLSKT-STDT 830

  Fly   917 AESYSRPMSRTSSMTPGM----RAKRSEIAQVIAPYEATSTEQLSLTRGQ 962
            .:: :.|:....|:...:    ..::.|:...:.|...|.|....|..|:
 Frog   831 FDA-TLPIKDKESLNKAIFEDDPTQKEEVPPALPPKTGTPTRPCPLPPGK 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	36/92 (39%)
		EH	18..83	CDD:238009	24/64 (38%)
		EH	184..279	CDD:197477	33/95 (35%)
		EH	195..261	CDD:238009	22/66 (33%)
		GBP_C	<366..467	CDD:303769	18/100 (18%)
		TACC	369..570	CDD:282818	51/220 (23%)
		coiled coil	432..443	CDD:293879	2/10 (20%)
		coiled coil	457..467	CDD:293879	3/9 (33%)
		TBPIP	<495..589	CDD:284512	29/113 (26%)
		SH3_Intersectin_1	674..728	CDD:212770	4/53 (8%)
		SH3_Intersectin_3	779..830	CDD:212772	11/50 (22%)
		SH3_Intersectin_4	941..998	CDD:212773	5/22 (23%)
		SH3_Intersectin_5	1025..1077	CDD:212774
eps15	NP_001120100.2	EH	10..102	CDD:197477
		EH	18..84	CDD:238009
		EH	119..213	CDD:197477	38/99 (38%)
		EH	130..195	CDD:238009	24/64 (38%)
		EH	254..350	CDD:197477	33/95 (35%)
		EH	266..329	CDD:238009	21/62 (34%)
		End3	<356..495	CDD:289527	43/218 (20%)
		TPR_MLP1_2	370..507	CDD:285204	39/180 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910