Protein Alignment Nhe2 and NHA1

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_013239.1
• Gene: NHA1 / 850829
• SGDID: S000004128
• Length: 985
• Species: Saccharomyces cerevisiae
• Alignment Length: 1045
• Identity: 200/1045 - (19%)
• Similarity: 346/1045 - (33%)
• Gaps: 342/1045 - (32%)

  Fly   201 IWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVV----------------------LYFC 243
            :.:.|:..:.:..::..||::  .||.:..:.|:::|.|                      :..|
Yeast    19 VGVFSSIFSLVSLYVKEKLYI--GESTVAGIFGLIVGPVCLNWFNPLKWGNSDSITLEITRIVLC 81

  Fly   244 TDV-AVSPLTPNTFF--------FYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATI 299
            ..: ||:...|..:.        ..:||  ::.||:.:        :|..:.:.:.|..|:.:
Yeast    82 LQIFAVAVELPRKYMLKHWVSVTMLLLP--VMTAGWLI--------IGLFVWILIPGLNFSAS-- 134

  Fly   300 GGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEI---LYIVVFGESLL 361
                                    .|.::.|:|.||:...:|........:   |..::..||..
Yeast   135 ------------------------LLISACITATDPILAQSVVSGKFAQRVPGHLRNLLSAESGC 175

  Fly   362 NDAVTVVMYHMMESYNEI---GLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDH 423
            ||.:......:  |.|.|   |..:.|.:|..  ..:.....|.|..:|...|::..:..||.:.
Yeast   176 NDGMAFPFLFL--SMNLILHPGNGREIVKDWI--CVTILYECLFGCLLGCFIGYVGRITIRFAEK 236

  Fly   424 VRVIE-PIFIFVMAYLAYLNAEIFHMSGI--LAITF-CGITM-------KNYVESNISQKSHTTV 477
            ..:|: ..|:.....||::.|....:.|:  |.::| .|.|.       :...|||:|......:
Yeast   237 KNIIDRESFLAFYVVLAFMCAGFGSILGVDDLLVSFAAGATFAWDGWFSQKTQESNVSTVIDLLL 301

  Fly   478 KYALKMLSSSAETIIFMFLGV----ATVNNMHV-WNTW-FVVLTIAFCSVFRVIGVILLSALANR 536
            .||           .|::.|.    :..||..: .|.| .::|:|....:.|:..|::|..|...
Yeast   302 NYA-----------YFIYFGAIIPWSQFNNGEIGTNVWRLIILSIVVIFLRRIPAVMILRPLIPD 355

  Fly   537 FRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDE------------NVVKQKN------------- 576
            .   |..|...||..:|.:.....||.:|...|            |||..|.
Yeast   356 I---KSWREALFVGHFGPIGVGAIFAAILARGELESTFSDEPTPLNVVPSKEESKHWQLIACIWP 417

  Fly   577 ---MFVTTTI-------AVIYFTVFLQGITIKPLVKILNVKRAN---------KRKPTMNE---- 618
               .|:.|:|       |:|.....|..||   |.|.......|         :|.|::::
Yeast   418 ITCFFIVTSIIVHGSSVAIITLGRHLNTIT---LTKTFTTHTTNGDNGKSSWMQRLPSLDKAGRS 479

  Fly   619 -RIHERFMDHLM------------------AGIEDIVG-----------------KTGNYNVRDK 647
             .:|.  ||..|                  ||.||..|                 ..|....|.|
Yeast   480 FSLHR--MDTQMTLSGDEGEAEEGGGRKGLAGGEDEEGLNNDQIGSVATSGIPARPAGGMPRRRK 542

  Fly   648 FKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEV-------------------------- 686
            ..|.:.|..|...:|: ||.|  |..:.||..|.|..|:
Yeast   543 LSRKEKRLNRRQKLRN-KGRE--IFSSRSKNEMYDDDELNDLGRERLQKEKEARAATFALSTAVN 604

  Fly   687 MRRNPSTIGQMTGTESMSALF--RNYTNNYIGGSPSLTNLDNTCS--------RN---------- 731
            .:|| ..|| |.|.|......  :.|::|| ..:||..:.:.:.|        ||
Yeast   605 TQRN-EEIG-MGGDEEEDEYTPEKEYSDNY-NNTPSFESSERSSSLRGRTYVPRNRYDGEETESE 666

  Fly   732 LDMAELDYNPSKKDLT---DARIHHLLAEELKPYRRHRRLSYSRHAVDDR--DLSTQVNYKMQMN 791
            ::..:...|.|::.:.   :.||..:..||:||...:  |..:|..::::  ::..||:.
Yeast   667 IESEDEMENESERSMASSEERRIRKMKEEEMKPGTAY--LDGNRMIIENKQGEILNQVDI----- 724

  Fly   792 FRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRK----KS 852
                                 |.:...:.:.||......:..|..:||.:.||....::    .|
Yeast   725 ---------------------EDRNEARDDEVSVDSTAHSSLTTTMTNLSSSSGGRLKRILTPTS 768

  Fly   853 YRKRHT-------HNSLNKYRRL-------------EIAEECQQNPNEINVVGPSDDWDDGLTFT 897
            ..|.|:       .|..:||...             ::.:..:.||::      |||
Yeast   769 LGKIHSLVDKGKDKNKNSKYHAFKIDNLLIIENEDGDVIKRYKINPHK------SDD-------- 819

  Fly   898 AKSSPDSDRANNNSLIAHIQNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGP-TAAELI 961
               ....:|..|:|:::......|. .|||...|   .|..|:  :..||.|.:. || ...:..
Yeast   820 ---DKSKNRPRNDSVVSRALTAVGL-KSKANSGV---PPPVDE--EKAIEGPSRK-GPGMLKKRT 874

  Fly   962 LPWRRDRSYQSI--VAEHPIPEEDRNLSRESDGERRVATPTATESQLPWKRQ------GDECTDA 1018
            |.....|..|..  :.:.|..|||...|...| :.......|.||:..::||      |:....|
Yeast   875 LTPAPPRGVQDSLDLEDEPSSEEDLGDSYNMD-DSEDYDDNAYESETEFERQRRLNALGEMTAPA 938

  Fly  1019 VQQNE 1023
            .|.:|
Yeast   939 DQDDE 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	128/666 (19%)
NHA1	NP_013239.1	c_cpa1	2..923	CDD:273295	194/1023 (19%)