DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and SLC9A7

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_001244220.1	Gene:	SLC9A7 / 84679	HGNCID:	17123	Length:	726	Species:	Homo sapiens

Alignment Length:	732	Identity:	205/732 - (28%)
Similarity:	329/732 - (44%)	Gaps:	139/732 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 ARPNTS-AVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKG 174
            |||.:. |.|..|.::.  ::..:....|..:|...|...|.....|:.:   |.|.:..|   .
Human     7 ARPGSGRATGAPPPRLL--LLPLLLGWGLRVAAAASASSSGAAAEDSSAM---EELATEKE---A 63

  Fly   175 DEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVV 239
            :|.|:.:  .:|.:.|..:.|..|:.||:...  .::.|     ||    |:.|.::.|:::||:
Human    64 EESHRQD--SVSLLTFILLLTLTILTIWLFKH--RRVRF-----LH----ETGLAMIYGLIVGVI 115

  Fly   240 LYF-------------CT--DVAVSPL------------------------------------TP 253
            |.:             ||  |.|.|.|                                    .|
Human   116 LRYGTPATSGRDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGEISPGKINSVEQNDMLRKVTFDP 180

  Fly   254 NTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGK-MGIYGE-SE 316
            ..||..:|||||..|||.:..|.||.|||:||..|.:||..:...||..:|...| |.|.|: |:
Human   181 EVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSCFIIGNLMYGVVKLMKIMGQLSD 245

  Fly   317 TPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGL 381
            .....|...|.::|||.|||.|||:|.|:|.:..||.::||||:|||||.:|:...:.:|...||
Human   246 KFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGESVLNDAVAIVLSSSIVAYQPAGL 310

  Fly   382 DKIIAQDIAS---GVGSFFVVALGGTAIGIIWGFLTGLVTRFTD-H-VRVIEPIFIFVMAYLAYL 441
            : ..|.|.|:   .||.|..:..|...:|.:.|.:|.|||:||. | ..::|....|:|::..:|
Human   311 N-THAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFTKLHCFPLLETALFFLMSWSTFL 374

  Fly   442 NAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVN-NMH 505
            .||....:|::|:.|||||..:|..:|:|.:|.:..|...::|...||..||.::|:|... ..|
Human   375 LAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRTKQLFEVLHFLAENFIFSYMGLALFTFQKH 439

  Fly   506 VWNTWFVVLTIAFCSVF--RVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVD 568
            |::..|::  .||.::|  |...:..||...|..|.||:....|.:|.:.|||||:||||.:...
Human   440 VFSPIFII--GAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNFQHMMMFSGLRGAMAFALAIRDT 502

  Fly   569 ENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIE 633
            .:..:|  |..|||:.:::|||::.|....|::..||: |....:|:..:: :|....:...|::
Human   503 ASYARQ--MMFTTTLLIVFFTVWIIGGGTTPMLSWLNI-RVGVEEPSEEDQ-NEHHWQYFRVGVD 563

  Fly   634 DIVGKTGNYNVRDKFK---------------------------RFDNRFIRPLLIRDLKGAEPKI 671
            .......|   .|.|:                           .||:.:::|:|..    :.|.:
Human   564 PDQDPPPN---NDSFQVLQGDGPDSARGNRTKQESAWIFRLWYSFDHNYLKPILTH----SGPPL 621

  Fly   672 IET---YSKLTMR--------DAMEVMRRNPS----TIGQMTGTESMSALFRNYTNNYIGGSPSL 721
            ..|   :..|..|        |..|.:|...|    |.|.:|.|...|.:..|.:::....|.||
Human   622 TTTLPAWCGLLARCLTSPQVYDNQEPLREEDSDFILTEGDLTLTYGDSTVTANGSSSSHTASTSL 686

  Fly   722 TNLDNTCSRNLDMAELD 738
            .....|.|.:.::.|.|
Human   687 EGSRRTKSSSEEVLERD 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	179/617 (29%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	151/463 (33%)
SLC9A7	NP_001244220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		5/12 (42%)
		Na_H_Exchanger	176..535	CDD:279355	134/363 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	568..591		3/25 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	670..715		8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810