DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and NHX1

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_198067.1	Gene:	NHX1 / 832773	AraportID:	AT5G27150	Length:	538	Species:	Arabidopsis thaliana

Alignment Length:	530	Identity:	149/530 - (28%)
Similarity:	250/530 - (47%)	Gaps:	83/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 LSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLI-----FPESCLLIVVGVVIGVVLYFCT 244
            ||:.|.|.| ....:.:.:|.|.|. :|       ||:     ..||...:::|:..||.:...:
plant    12 LSTSDHASV-VALNLFVALLCACIV-LG-------HLLEENRWMNESITALLIGLGTGVTILLIS 67

  Fly   245 DVAVSPL---TPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIG-GSLYA 305
            ....|.|   :.:.||.|:|||||.:||:.:..:.||.|..||:|...||||.:...|. |....
plant    68 KGKSSHLLVFSEDLFFIYLLPPIIFNAGFQVKKKQFFRNFVTIMLFGAVGTIISCTIISLGVTQF 132

  Fly   306 CGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMY 370
            ..|:.|    .|..|.|.....::.:|.|.|..|.|..: ....:||.:||||.::|||.:||::
plant   133 FKKLDI----GTFDLGDYLAIGAIFAATDSVCTLQVLNQ-DETPLLYSLVFGEGVVNDATSVVVF 192

  Fly   371 HMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTR---FTDHVRVIEPIFI 432
            :.::|::...|:...|..:   :|:|..:.|..|.:|...|.::..|.:   |..|....|...:
plant   193 NAIQSFDLTHLNHEAAFHL---LGNFLYLFLLSTLLGAATGLISAYVIKKLYFGRHSTDREVALM 254

  Fly   433 FVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLG 497
            .:||||:|:.||:|.:||||.:.||||.|.:|...|:::.|..|.|:....||..|||.||:::|
plant   255 MLMAYLSYMLAELFDLSGILTVFFCGIVMSHYTWHNVTESSRITTKHTFATLSFLAETFIFLYVG 319

  Fly   498 VATVNNMHVWNTWFVV-----LTIAFCSVFRVIGVIL------------LSALANRFRLHKLSRV 545
            :..::    .:.|..|     .:||..|:  ::|:::            ||.||.:.:..|::..
plant   320 MDALD----IDKWRSVSDTPGTSIAVSSI--LMGLVMVGRAAFVFPLSFLSNLAKKNQSEKINFN 378

  Fly   546 DQFVMSYGGL-RGAVAFALV----LLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKIL- 604
            .|.|:.:.|| ||||:.||.    .......|:...:.:|:||.|..|:..:.|:..|||:..|
plant   379 MQVVIWWSGLMRGAVSMALAYNKFTRAGHTDVRGNAIMITSTITVCLFSTVVFGMLTKPLISYLL 443

  Fly   605 ---NVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYN-----------------VRDKFK 649
               |...:........:.||...:|.     :..:..:||:|                 |...::
plant   444 PHQNATTSMLSDDNTPKSIHIPLLDQ-----DSFIEPSGNHNVPRPDSIRGFLTRPTRTVHYYWR 503

  Fly   650 RFDNRFIRPL 659
            :||:.|:||:
plant   504 QFDDSFMRPV 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	147/526 (28%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	130/436 (30%)
NHX1	NP_198067.1	b_cpa1	44..>468	CDD:273294	128/437 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910