Protein Alignment Nhe2 and slc9a1b

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001106952.1
• Gene: slc9a1b / 795135
• ZFINID: ZDB-GENE-080225-42
• Length: 653
• Species: Danio rerio
• Alignment Length: 644
• Identity: 283/644 - (43%)
• Similarity: 417/644 - (64%)
• Gaps: 55/644 - (8%)

  Fly   164 PLKSGDENAKGDEGHKMER--YPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPES 226
            ||..|  :.:|.:.::.::  :|:.|:::..|:.||.|.:|||.|||.|:|||:.|.:..:.|||
Zfish    10 PLLIG--SCRGIDHNETDQRVFPVISINYQHVQMPFEISLWILLASILKLGFHLVPHVSAVVPES 72

  Fly   227 CLLIVVGVVI-GVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVV 290
            |:|||||::: |::.....|..|  |....||..:|||||||||||:|.|.|.:|:||||..||:
Zfish    73 CVLIVVGLLVGGLIRVLGEDPPV--LDSQLFFLCLLPPIILDAGYFLPIRPFMENVGTILTFAVL 135

  Fly   291 GTIFNIATIGGSLY-ACGKMGIYGESETPG--LMDVFLFASLISAVDPVAVLAVFEEIHVNEILY 352
            ||:::...:|.:|| ||...|    :|..|  |:...||.|::||||||||||||:|||:||:|:
Zfish   136 GTLWSAFFMGVALYGACQLEG----AELAGVDLLSCLLFGSIVSAVDPVAVLAVFQEIHINELLH 196

  Fly   353 IVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLV 417
            |:||||||||||||||:||:.|.:...|  ::.|.|:..||..||||::||..:|.::|||....
Zfish   197 ILVFGESLLNDAVTVVLYHLFEEFVHRG--EVTAGDVFLGVVCFFVVSVGGVLVGCVYGFLAAFT 259

  Fly   418 TRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALK 482
            :|||.|.|||||:|:|:.:|:|||:||:||:|||:|:..||:.|:.|||:|||.||:||:||.||
Zfish   260 SRFTAHTRVIEPLFVFLYSYMAYLSAEVFHLSGIMALIACGVVMRPYVEANISHKSYTTIKYFLK 324

  Fly   483 MLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQ 547
            |.||.:||:||:||||:||...|.||..||.||:..|.:.||:||:.|:.:.|::|:.|||..||
Zfish   325 MWSSVSETLIFIFLGVSTVAGPHAWNWTFVSLTLVLCLLSRVLGVVGLTFIINKYRMVKLSGKDQ 389

  Fly   548 FVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKR 612
            |:::|||||||:||:|..|:.......|::|:|..|.||:||||:||:||:|||.:|.||:..:.
Zfish   390 FIVAYGGLRGAIAFSLAFLLSSESCAMKDLFLTAVITVIFFTVFVQGMTIRPLVDLLAVKKKKQS 454

  Fly   613 KPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSK 677
            |.::||.||.:|::||:.||||:.|..|:::.|||..||:.|::...||...:..||::|..|.:
Zfish   455 KFSVNEEIHTQFLEHLLTGIEDVCGHYGHHHWRDKISRFNKRYMMRFLIGGERSQEPQLISFYKQ 519

  Fly   678 LTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPS 742
            :.:...|:::..|.:|        |:|:              :.|.|.....|.|       |.|
Zfish   520 MELEQTMKMLENNSTT--------SLSS--------------AATQLHQRSKRTL-------NIS 555

  Fly   743 KKDLTDARIHHLLAEELKPYRRHRRLSYSRHAV------DDRDLSTQVNYKMQMNFRRM 795
            |:  .:|.|..:|...|:..|:..| |||||.:      ||...:.....:|:|. |||
Zfish   556 KE--REAEIRKMLRANLQKTRQRLR-SYSRHTLLPDAEEDDWSETRLRKQRMEME-RRM 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	251/518 (48%)
		Na_H_Exchanger	199..602	CDD:279355	214/406 (53%)
slc9a1b	NP_001106952.1	b_cpa1	36..591	CDD:273294	270/594 (45%)
		Na_H_Exchanger	45..443	CDD:279355	213/405 (53%)
		NEXCaM_BD	533..628	CDD:293250	28/111 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740