Protein Alignment Nhe2 and slc9a6a

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_009289416.1
• Gene: slc9a6a / 792983
• ZFINID: ZDB-GENE-070424-104
• Length: 732
• Species: Danio rerio
• Alignment Length: 755
• Identity: 197/755 - (26%)
• Similarity: 301/755 - (39%)
• Gaps: 238/755 - (31%)

  Fly   173 KGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIG 237
            |.:|.|:.:...|  :.|..:.|..|:.||:......:.       ||    |:.|.::.|:::|
Zfish    50 KAEESHRQDSADL--LIFIMLLTLTILTIWLFKHRRFRF-------LH----ETGLAMIYGLLVG 101

  Fly   238 VVLYFCTDVA-------------VSPLT------------------------------------- 252
            |||.:...|.             .||.|
Zfish   102 VVLRYAIHVPSDINNVTLSCHVNASPATLLVNVSGKFYEYTLKGEIGANKVNDIQDNEMLRKVTF 166

  Fly   253 -PNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYAC----GKMGIY 312
             |..||..:|||||..|||.:..|.||.|||:||..|.|||:.:...||..:|.|    .|:|
Zfish   167 DPEVFFNILLPPIIFHAGYSLKRRHFFRNLGSILAYAFVGTVVSCFIIGALMYGCVMLMKKIG-- 229

  Fly   313 GESETPGLMDVF------LFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYH 371
                  .|.|.|      .|.:::||.|||.|||:|.|:.|:..||.::||||:|||||.||:..
Zfish   230 ------HLQDDFFFTDCLFFGAIVSATDPVTVLAIFNELQVDADLYALLFGESVLNDAVAVVLSS 288

  Fly   372 MM----------------ESYNEIG-------LDKII--------------AQDIASGVGSFFVV 399
            |:                .:|.|.|       |:..|              |..:....|.|..|
Zfish   289 MLLYYGRQSGAGHHSPGGVAYAEGGNQTQRPPLNGSIVAYQPTGDNSHTFEAMAMLKSFGIFLGV 353

  Fly   400 ALGGTAIGIIWGFLTGLVTRFTD--HVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMK 462
            ..|..|:|:..|.:|.|||:||.  ...::|....|:|::..:|.||....:|::|:.|||:|..
Zfish   354 FSGSFALGVATGIVTALVTKFTKLRDFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGMTQA 418

  Fly   463 NYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVA--TVNNMHVWNTWFVVLTIAFCSVF--R 523
            :|..:|:|.:|....|...::|:..||..||.::|:.  |..| ||:|..|:|  .||.:||  |
Zfish   419 HYTFNNLSPESQDRTKQLFELLNFLAENFIFSYMGLTLFTFQN-HVFNPIFIV--CAFLAVFLGR 480

  Fly   524 VIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYF 588
            ...:..||.|.|..|.:|:|...|.:|.:.|||||:.||  |.:.:.....:.|..:||:.|::|
Zfish   481 AANIYPLSFLLNLGRRNKISSNFQHMMMFAGLRGAMTFA--LSIRDTATYARQMMFSTTLLVVFF 543

  Fly   589 TVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDK------ 647
            ||::.|   ....::|:.::......|          ||     |:.:|..|......|
Zfish   544 TVWICG---GGTTQMLSCQKIRVGVDT----------DH-----ENSIGPDGVERRSTKQESAWL 590

  Fly   648 ---FKRFDNRFIRPLLIR------------------------------DLKGAEPKIIETYSKLT 679
               :..||:.:::|:|..                              :||.|:..:|.....:|
Zfish   591 FRIWYNFDHNYLKPILTHSGPPLTATLPACCSPLARCLTSPQAYENEGELKNADSDLILNDGDIT 655

  Fly   680 MRDAMEVMRRNPSTIGQM------TGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAE-- 736
            :            |.|.:      ||..|...|        :||  :..|.|....|.|...:
Zfish   656 L------------TYGDIAVSTDGTGAHSSGVL--------MGG--AAVNSDEALDRELAFGDHE 698

  Fly   737 ---------LDYNPSKKDLTDARIHHLLAEELKPYR-RHR 766
                     |..:.|:..||           |..:| |||
Zfish   699 LVIRGTRLVLPMDDSEPPLT-----------LDSHRQRHR 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	177/663 (27%)
		Na_H_Exchanger	199..602	CDD:279355	152/506 (30%)
slc9a6a	XP_009289416.1	Na_H_Exchanger	164..556	CDD:279355	137/407 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810