DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and SLC9A5

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_004585.1	Gene:	SLC9A5 / 6553	HGNCID:	11078	Length:	896	Species:	Homo sapiens

Alignment Length:	1042	Identity:	371/1042 - (35%)
Similarity:	523/1042 - (50%)	Gaps:	213/1042 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 EPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESC 227
            ||.:..:...:...|.::.|:     .:..|:.|:::.:|||.||:|||.||::.|:..:.||||
Human    19 EPTQKPESPGEPPPGLELFRW-----QWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESC 78

  Fly   228 LLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGT 292
            |||::|:|:|.::......|...|.|.|||.::||||:||:|||||:||||||||.||..|||||
Human    79 LLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGT 143

  Fly   293 IFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFG 357
            ::|..|.|.:|:...:.|:.......||:|..||.|||||||||||||||||:||||.|:|:|||
Human   144 LWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFG 208

  Fly   358 ESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTD 422
            |||||||||||:|.:..|:.|:|...:.|.|...||.|.|||:|||.|:|:::.||..|.||||.
Human   209 ESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTK 273

  Fly   423 HVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSS 487
            .||:|||:.:|::||.|||.||:..:|.|||:|.||:..|.|||:|||.||.|||||.:|.|:|.
Human   274 RVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASC 338

  Fly   488 AETIIFMFLGVATVNNMH-VWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMS 551
            |||:|||.||::.|::.. .|::..|:.|:.|...||.:||:|.:.:.|:|||..|.::||.|||
Human   339 AETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMS 403

  Fly   552 YGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTM 616
            |||||||||||||:|:|...|..|:.||.|||.|::|||.:||:|||||||.|.|||:...|||:
Human   404 YGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTL 468

  Fly   617 NERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGA---EPKIIETYSKL 678
            |:.:||...||::|.:||:||..|.:..||::::||.:::..||:|  :.|   ..:|.:.|.:|
Human   469 NQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMR--RSAYRIRDQIWDVYYRL 531

  Fly   679 TMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNL-----DNTCSRNLDMAELD 738
            .:|||:..:.:....:.. ||....|...||..     ...|:|||     ...|   ||:..:|
Human   532 NIRDAISFVDQGGHVLSS-TGLTLPSMPSRNSV-----AETSVTNLLRESGSGAC---LDLQVID 587

  Fly   739 YNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRR---MFNDRK 800
            ...|.:|..||.:||||...|...||..:.|.|||.:.:.....|.....|.|.:|   .|...|
Human   588 TVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTK 652

  Fly   801 HH--------------KRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKK 851
            |:              :|.|.|.:|.|| .|.|...:.|.|      |..:....||.
Human   653 HNICFTKSKPRPRKTGRRKKDGVANAEA-TNGKHRGLGFQD------TAAVILTVESE------- 703

  Fly   852 SYRKRHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHI 916
                             |..||...:..|      .:| |:|:.|.|:::  |:......:...:
Human   704 -----------------EEEEESDSSETE------KED-DEGIIFVARAT--SEVLQEGKVSGSL 742

  Fly   917 QNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPE 981
            :..|                           ||.          |:|
Human   743 EVCP---------------------------SPR----------IIP------------------ 752

  Fly   982 EDRNLSRESDGERRVATPTATESQLPWKR-QGD-------ECTDAVQQNEFPAW---ASNKEYLA 1035
                           .:||..|.:||||. |||       |.|..|..:....|   .|:.|.||
Human   753 ---------------PSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLA 802

  Fly  1036 ----YNSPSATFLGGINKPKQPKSVIGLFRRESSSSKAGSVGVGSTGAMDSAASGSETMVVSMSS 1096
                ..:|..|.|     |..|:                               |:|...|.:
Human   803 SPPCNQAPILTCL-----PPHPR-------------------------------GTEEPQVPL-- 829

  Fly  1097 QPPNAPSTSI-HNPRLDKRSQSISSSSLGAGAHQ-----LGPEGHSGPFPVTASHRRNVR--RGS 1153
            ..|:.|.:|. ..|.|.|..:|.|.||......|     :|.:.|:...|.||:....::  |||
Human   830 HLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGS 894

  Fly  1154 ML 1155
            .|
Human   895 RL 896

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	260/518 (50%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	222/403 (55%)
SLC9A5	NP_004585.1	NhaP2	41..630	CDD:330436	286/599 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..686		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..720		7/49 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	818..864		14/78 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158315
Domainoid	1	1.000	491	1.000	Domainoid score	I372
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31247
Inparanoid	1	1.050	588	1.000	Inparanoid score	I1000
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm41698
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2680
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.780