DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nhe2 and SLC9A1

DIOPT Version :9

Sequence 1:NP_001137851.1 Gene:Nhe2 / 35376 FlyBaseID:FBgn0040297 Length:1322 Species:Drosophila melanogaster
Sequence 2:NP_003038.2 Gene:SLC9A1 / 6548 HGNCID:11071 Length:815 Species:Homo sapiens


Alignment Length:677 Identity:294/677 - (43%)
Similarity:427/677 - (63%) Gaps:67/677 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 VGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVG-LDPTPSARVPRPEPLKSGDENAKGDEGHKME 181
            ||:.|...|..:..:.|...:..|.|.....:| :...|....|...|:    .::..|.|.|..
Human    26 VGLLPVLRSHGLQLSPTASTIRSSEPPRERSIGDVTTAPPEVTPESRPV----NHSVTDHGMKPR 86

  Fly   182 R-YPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTD 245
            : :|:..:|:..|:|||.|.:|||.|.:.|||||:.|.:..|.||||||||||:::|.::   ..
Human    87 KAFPVLGIDYTHVRTPFEISLWILLACLMKIGFHVIPTISSIVPESCLLIVVGLLVGGLI---KG 148

  Fly   246 VAVSP--LTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGK 308
            |..:|  |..:.||.::|||||||||||:|.|.|.:||||||:.|||||::|...:||.:||...
Human   149 VGETPPFLQSDVFFLFLLPPIILDAGYFLPLRQFTENLGTILIFAVVGTLWNAFFLGGLMYAVCL 213

  Fly   309 MGIYGES-ETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHM 372
            :|  ||. ...||:|..||.|:|||||||||||||||||:||:|:|:||||||||||||||:||:
Human   214 VG--GEQINNIGLLDNLLFGSIISAVDPVAVLAVFEEIHINELLHILVFGESLLNDAVTVVLYHL 276

  Fly   373 ME---SYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFV 434
            .|   :|..:|:     .||..|..|||||||||..:|:::|.:....:|||.|:|||||:|:|:
Human   277 FEEFANYEHVGI-----VDIFLGFLSFFVVALGGVLVGVVYGVIAAFTSRFTSHIRVIEPLFVFL 336

  Fly   435 MAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVA 499
            .:|:|||:||:||:|||:|:...|:.|:.|||:|||.|||||:||.|||.||.:||:||:||||:
Human   337 YSYMAYLSAELFHLSGIMALIASGVVMRPYVEANISHKSHTTIKYFLKMWSSVSETLIFIFLGVS 401

  Fly   500 TVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALV 564
            ||...|.||..||:.|:.||.:.||:||:.|:...|:||:.||:..|||:::|||||||:||:|.
Human   402 TVAGSHHWNWTFVISTLLFCLIARVLGVLGLTWFINKFRIVKLTPKDQFIIAYGGLRGAIAFSLG 466

  Fly   565 LLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLM 629
            .|:|:......::|:|..|.||:||||:||:||:|||.:|.||:..:.|.::||.||.:|:|||:
Human   467 YLLDKKHFPMCDLFLTAIITVIFFTVFVQGMTIRPLVDLLAVKKKQETKRSINEEIHTQFLDHLL 531

  Fly   630 AGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEV-----MRR 689
            .|||||.|..|:::.:||..||:.::::..||...:..||::|..|.|:.|:.|:|:     |.:
Human   532 TGIEDICGHYGHHHWKDKLNRFNKKYVKKCLIAGERSKEPQLIAFYHKMEMKQAIELVESGGMGK 596

  Fly   690 NPSTIGQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDL------TD 748
            .||.:                         |..::.|...::|        ||::.|      .:
Human   597 IPSAV-------------------------STVSMQNIHPKSL--------PSERILPALSKDKE 628

  Fly   749 ARIHHLLAEELKPYRRHRRLSYSRHAV 775
            ..|..:|...|:..|:..| ||:||.:
Human   629 EEIRKILRNNLQKTRQRLR-SYNRHTL 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nhe2NP_001137851.1 b_cpa1 189..704 CDD:273294 264/525 (50%)
Na_H_Exchanger 199..602 CDD:279355 222/408 (54%)
SLC9A1NP_003038.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..79 7/40 (18%)
b_cpa1 95..660 CDD:273294 279/604 (46%)
Na_H_Exchanger 105..503 CDD:279355 221/407 (54%)
Interaction with TESC. /evidence=ECO:0000269|PubMed:30287853 503..545 20/41 (49%)
Interaction with CHP2. /evidence=ECO:0000269|PubMed:21392185 515..545 16/29 (55%)
NEXCaM_BD 602..700 CDD:293250 15/62 (24%)
Interaction with CALM1. /evidence=ECO:0000269|PubMed:30287853 633..815 8/23 (35%)
Interaction with TESC. /evidence=ECO:0000269|PubMed:12809501 633..815 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..815
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158313
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0025
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000129
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101278
Panther 1 1.100 - - O PTHR10110
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.740

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