Protein Alignment Nhe2 and slc9a3.2

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001106951.1
• Gene: slc9a3.2 / 568314
• ZFINID: ZDB-GENE-060503-640
• Length: 851
• Species: Danio rerio
• Alignment Length: 864
• Identity: 294/864 - (34%)
• Similarity: 461/864 - (53%)
• Gaps: 123/864 - (14%)

  Fly   172 AKGDEGHK--MERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGV 234
            :.|:..|.  :...|:.:..:..|:||:::.:|||:..|.|:...:...:..:.|||.|||::|.
Zfish    46 SSGNSSHSATITTLPIVTWKWHHVETPYLVALWILTCWICKLVTELNHNITSVIPESGLLIILGF 110

  Fly   235 VIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATI 299
            ::|.:::.........|.|..||||:||.|||||.|.|||:|||.|||.||:.|::||.:|..|:
Zfish   111 ILGGIVWGADKAQTFKLIPVNFFFYLLPQIILDASYCMPNKLFFGNLGAILVHAIIGTCWNAGTV 175

  Fly   300 GGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDA 364
            |.:|:||.:.|..|.... |.:...||.:|:||||||||:|||||:||||:|||:|||||||||.
Zfish   176 GIALWACYEGGAMGTLNI-GCLQFLLFGALMSAVDPVAVIAVFEEVHVNEVLYILVFGESLLNDG 239

  Fly   365 VTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEP 429
            ||||:|::.:::..:|..||.|.:|..|:.||.|||.||:.:|:::..||.::||.|.:|::||.
Zfish   240 VTVVLYNVFDAFVSLGGPKINAAEIIKGIVSFAVVAFGGSFLGVVFAVLTSMLTRVTKNVQIIEA 304

  Fly   430 IFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFM 494
            .||.|:.||:||.||:..:|.||::||||:..:.|:.:|:.:||.|.::|:||:|::.:||:||:
Zfish   305 GFIIVLGYLSYLTAEMLSLSAILSLTFCGVCCQKYINANMDEKSVTCLRYSLKVLANGSETMIFV 369

  Fly   495 FLGVATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGA 558
            ||||:.:: .:.||||.|::||:.|..|||::||..|:.:.|:.||..:...||.||.|||||||
Zfish   370 FLGVSAIDQTIWVWNTGFILLTLLFIVVFRMMGVFFLNWILNQSRLIPIDLTDQLVMGYGGLRGA 434

  Fly   559 VAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHER 623
            ||:.|...:|||.:.:||:.:.||:.|:||||.|||||:||||..|.||:|.:...|:|.:::.|
Zfish   435 VAYGLAASLDENKIPEKNLMLGTTLIVVYFTVILQGITMKPLVNWLKVKKATQSDLTLNGKLNNR 499

  Fly   624 FMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLI-RDLKGAEPKIIETYSKLTMRDAMEVM 687
            ..:|.:.|:|||.|:.|:......:..|:.:::..||: .:.:....||::.:.||.:.||.:.:
Zfish   500 VFEHTLTGMEDICGRMGDNWWTRHWNHFEEKYVCWLLMTSEARKRNDKILDAFHKLNVEDATKYV 564

  Fly   688 RRNPSTIGQMTGTESMSALFRNYTNNYIGGSP--SLTNLDNTCSRNLDMAELDYNPSKKDLT--- 747
            ..     |:..|:   .|..|:|.:..:....  :|...|.......||:|.|::.....:|
Zfish   565 NE-----GESKGS---LAFIRSYDSASVDFKKKLALEYADIIPDIMADMSEYDFDIDSVPVTSVM 621

  Fly   748 ---------------------DARIHHLLAEELKPYRRHRRLSYSRHAVDDRDLSTQVN-YKMQM 790
                                 |...||||.:.|...||:.|.:|||     ...:|..| .:||.
Zfish   622 KNPIPSVSLDIHEQERRGMSNDLNAHHLLEQHLYKSRRNNRATYSR-----SHYNTSENPDEMQE 681

  Fly   791 NFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKKSYRK 855
            .|:|...:|..        |.|.||..|                    |..:..|.|.:|.:..|
Zfish   682 IFQRTMGNRLE--------SFKSAKMGV--------------------NPAKKVSKHPKKDAPHK 718

  Fly   856 RHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHIQNLP 920
            .:...:               :||..::.|     |:...|:|.|:..|:  |.......:.|..
Zfish   719 PNGKPA---------------DPNRDHLYG-----DEDFEFSADSASSSE--NTCQFPRRVINTT 761

  Fly   921 GFDASKARIVVQHYAPKADDNPDTDIESP--------EQAIGPT-AAELILPW-----RR----- 966
            |     |.:....|.|:.|.:|  .:.:|        ..|:.|: .|:..|||     ||
Zfish   762 G-----AGVDNPAYIPELDTSP--SMRNPPWQTETGHNTAVAPSQRAQGRLPWTPTNLRRLAPLR 819

  Fly   967 --DRSYQSIVAEHPIPEED 983
              .||..|.....|..:|:
Zfish   820 VSSRSTDSFAMPEPAADEE 838

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	222/516 (43%)
slc9a3.2	NP_001106951.1	Na_H_Exchanger	65..584	CDD:470090	225/527 (43%)