DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and slc9a3.1

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_001106944.1	Gene:	slc9a3.1 / 568258	ZFINID:	ZDB-GENE-060503-545	Length:	832	Species:	Danio rerio

Alignment Length:	858	Identity:	291/858 - (33%)
Similarity:	455/858 - (53%)	Gaps:	138/858 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 SARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIG-FHMTPKL 219
            |..||.|...::  ||..|        .|:.:..:..|:||:::.:|:..|.:||:. ..:...:
Zfish    27 SVEVPNPHHHQT--ENLTG--------LPIVTFKWHHVETPYLVALWVFVAGLAKLSVIQLNHSI 81

  Fly   220 HLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTI 284
            ..:||||.|||::|.::|.::..........|.|:|||:|:||.|||||.|||||:|||.|||.|
Zfish    82 TGVFPESGLLIILGFILGGIVVGADKAQTFKLLPSTFFYYLLPQIILDASYFMPNKLFFRNLGAI 146

  Fly   285 LLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNE 349
            |:.|:.||.:|.|.:|.||:.|.:.|..|:... ||:...||..||:|||||||:|||||:||||
Zfish   147 LIYAIFGTCWNAAAVGLSLWGCHEAGAMGDLNI-GLLQFLLFGGLIAAVDPVAVIAVFEEVHVNE 210

  Fly   350 ILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLT 414
            :|:|:|||||||||.||||:|::.:.:..:|...|.|.:|..|:.||.|||.||:.:|:.:..|.
Zfish   211 VLFILVFGESLLNDGVTVVLYNVFDGFVSLGGPMIDAAEIFKGICSFVVVAFGGSFVGVAFAILL 275

  Fly   415 GLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKY 479
            .|:||.|.||::||..|:|::.||:||..|:..:|.||:.||||:..:.|:.:|:.::|.|||::
Zfish   276 SLLTRCTKHVQIIEAGFVFLVGYLSYLTVEMLSLSAILSTTFCGVCCQKYINANMDERSVTTVRH 340

  Fly   480 ALKMLSSSAETIIFMFLGVATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLS 543
            |:|||::.:||:||:||||..:: .:.||||.|::||:.|..::|:|||.:.:.:.|:|||..:.
Zfish   341 AMKMLANGSETMIFLFLGVTAIDTEIWVWNTGFILLTLLFIFIYRIIGVFMFTWMLNKFRLVPVE 405

  Fly   544 RVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKR 608
            .:||.||||||||||||:.|..::||:.:.:|.:.::||:.|:||||.|||.|:||||:.|.|||
Zfish   406 LIDQVVMSYGGLRGAVAYGLAAMLDESTIPEKKLMISTTLIVVYFTVILQGTTMKPLVQWLKVKR 470

  Fly   609 ANKRKPTMNERIHERFMDHLMAGIEDIVGKTG-NYNVRDKFKRFDNRFIRPLLIRDLKGAEPK-- 670
            |......:.|:::.|..||::|.:|||.|:.| |:..|. :.||:.::|..||::      ||
Zfish   471 AAHSDLKLVEKLNNRAFDHILAAVEDICGRIGDNWWTRG-WNRFEEKYISWLLMK------PKAR 528

  Fly   671 -----IIETYSKLTMRDAMEVMRRNPSTIGQMTGT-------ESMSALFRNY------------- 710
                 :...:.||.:.|||     |..:.|:..|:       |:.:..|:..
Zfish   529 KNRDYLFNIFHKLNLEDAM-----NYVSEGERQGSLAFIRNDEAANVDFKKQFDSEFADVMPDIM 588

  Fly   711 --TNNYIGGSPSLTNL----DNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLS 769
              .:||..|..:::..    |...|.:||:...|   .|..:.|...|.||.:.|...|:|....
Zfish   589 VDMSNYDFGIENISAAAIVKDTIPSVSLDIHGQD---GKNVVDDINAHRLLQQHLYRSRKHHHHK 650

  Fly   770 YSRHAVDDRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTT 834
            |||....    ..|...::|..|:|....|..        |.|.||..|
Zfish   651 YSRSHFS----INQSEEEVQEIFQRTMRSRLE--------SFKSAKMGV---------------- 687

  Fly   835 KQLTNGTESSSNHSRKKSYRKRHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAK 899
                |.|:..:...:|....|.:.|...|.|                 :.|  |:.|.|:
Zfish   688 ----NPTKKITKFHKKDPTDKMNGHTEGNGY-----------------LYG--DEADSGV----- 724

  Fly   900 SSPDSDRANNNSLIAHIQNLPGFDASKARIVVQH--YAPKADDNPDTDIESP------EQAIGPT 956
               .:|.|.:::.:.        |..|....:::  :.|..|....:.:.||      |.::.|:
Zfish   725 ---GADGAISSTFMR--------DTYKMGAGIENPVFMPDMDSPVHSPVHSPPWLLETEMSVAPS 778

  Fly   957 -AAELILPWRRDR 968
             .|:..|||..:|
Zfish   779 QRAQRRLPWTPNR 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	227/531 (43%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	190/404 (47%)
slc9a3.1	NP_001106944.1	b_cpa1	50..563	CDD:273294	226/525 (43%)
slc9a3.1	NP_001106944.1	Na_H_Exchanger	60..465	CDD:279355	191/405 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594228
Domainoid	1	1.000	431	1.000	Domainoid score	I564
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm25967
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2680
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730