DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and slc9a5

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_001106943.1	Gene:	slc9a5 / 565213	ZFINID:	ZDB-GENE-080225-43	Length:	970	Species:	Danio rerio

Alignment Length:	1083	Identity:	383/1083 - (35%)
Similarity:	538/1083 - (49%)	Gaps:	211/1083 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 DAVTQLNL-GQSAP----IDAVDVGLDPTPSARVPR-------------PEPLKSGDENAKGDEG 177
            ||||.|.: |.|.|    :.|......|..:..:||             .||.....|:.:....
Zfish    15 DAVTDLYVTGASLPPKLGVSAAPPATSPVAARYIPREYGHPGIALARSAEEPTTPSTEDGESSHH 79

  Fly   178 H----KMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGV 238
            |    |:.::     :::.|:||:||..|:|.||:|||.||.:.:.....||||:||::|:.:|.
Zfish    80 HGGGFKIVQW-----EWSYVQTPYIIASWLLVASVAKILFHFSQRFTTAVPESCMLILLGLALGT 139

  Fly   239 VLYFCTDVAVSPLTPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSL 303
            |:...:......|.|..||.::||.|:.|||||||.||||||||.||:.|||||::|....|..|
Zfish   140 VVLLASKKQPYQLDPGLFFLFLLPTIVGDAGYFMPARLFFDNLGAILMYAVVGTLWNAFCTGFCL 204

  Fly   304 YACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVV 368
            |.....|:..|....|||:..||.:||||||||||||||||:||||.|:|:||||||||||||||
Zfish   205 YGVKMAGVIDEKVDAGLMEFLLFGALISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVV 269

  Fly   369 MYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIF 433
            :|.:..|:.|:|...:...|...|:.||.:|::|||.:|:|:..:....||||..||:|||:|||
Zfish   270 LYKVYISFVEVGPGNVNTADYFKGIASFLIVSIGGTLVGLIFAVILAFFTRFTKKVRIIEPMFIF 334

  Fly   434 VMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGV 498
            ::.|||||.||:|.:|.||::|||||....|||:||||||.|||||.:|.|:|.||||||:|||:
Zfish   335 LLVYLAYLTAELFSLSAILSLTFCGIGCNKYVEANISQKSRTTVKYTMKTLASIAETIIFIFLGI 399

  Fly   499 ATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFA 562
            :.|: :...|:|..||.|:.|..|||.:|||..:...|.|||..|.::||.||||||||||||||
Zfish   400 SAVDKSKWAWDTGLVVSTLIFILVFRAMGVIGQTWFLNWFRLVPLDKIDQVVMSYGGLRGAVAFA 464

  Fly   563 LVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDH 627
            ||:|:|:..||.|:.||.|||.|::|||..||:|||||||.|.|.|:..||||:||.||||..||
Zfish   465 LVVLLDKEHVKAKDYFVATTIVVVFFTVMFQGLTIKPLVKWLKVPRSTNRKPTINEEIHERAFDH 529

  Fly   628 LMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETYSKLTMRDAMEVMRRNPS 692
            ::|.:|||.|..|.::.|||:::||..::..||:|.....:.::.|.|.|:.:|||:.|:.:..:
Zfish   530 ILAAVEDIAGLNGYHHWRDKWEQFDKNYLSKLLLRKSVYHKSELWEAYQKINIRDAISVIDQGGN 594

  Fly   693 TI-GQMTGTESMSALFRNYTNNYIGGSPSLTNLDNTCSRN-----LDMAELDYNPSKKDLTDARI 751
            .: .......||::.         ...|.:||:.|....|     ||:..:|..|..|...:...
Zfish   595 VLTSARVSLPSMASR---------TSFPEVTNVTNYLRENGSGVCLDLQVIDTVPGAKIEEELET 650

  Fly   752 HHLLAEEL-KPYRRHRRLSYSRHAVDDRDLSTQVNYKMQMNFRRMFNDRK--HHKRSKRGASNKE 813
            ||:||..| ||.||::. .||||.:...:...|.....|.|.|......|  .:||.|:..|.|:
Zfish   651 HHVLAGNLYKPRRRYQS-HYSRHFMTLGEKERQDREVFQRNMRNRLESFKSTRYKRHKKDRSQKK 714

  Fly   814 AK-ENVKQNHVSFHDFQQNGTTKQLTNGTESSSNHSRKKSYRKRHTHNSLNKYRRLEIA----EE 873
            .| .:.|:.                    ::|....|..|::.:..          .:|    ||
Zfish   715 RKGSDAKEQ--------------------DTSDEPRRNVSWQDKDP----------LVAPLATEE 749

  Fly   874 CQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRANNNSLIAHIQNLPGFDASKARIVVQHYAPKA 938
            .:.:|.|::    .|| |.|:.|.|:.:|::                               ||
Zfish   750 DKHDPTEVD----KDD-DVGIIFVARRTPET-------------------------------PK- 777

  Fly   939 DDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPEEDRNLSRESDGERRVATPTAT- 1002
                    |.|:..  |.|.:              |.:.||                .|.|:.|
Zfish   778 --------ERPKSV--PAALD--------------VCQSPI----------------TAPPSLTC 802

  Fly  1003 -ESQLPWKR-QGD-------ECTDAVQQNEFPAW---ASNKEYLAYNSPSATFLGGINKPKQPK- 1054
             |..||||. .|.       |.|..:..:...||   .|:.|.||  ||.|.     .:|..|:
Zfish   803 GEKNLPWKSGMGSLPPCVSVEATKIIPVDLQQAWNQSISSLESLA--SPPAP-----AEPLHPRI 860

  Fly  1055 ---SVIGLFRRESSSSKAGSVGVGSTGAMDSAASGS----------------------ETMVVSM 1094
               |.:|...|..:..|:..|..|......|.:||.                      :.::.|:
Zfish   861 SALSRLGGPLRTPAKDKSAGVDAGLESTTSSPSSGQFKYPMGKEEEEEGALSQQHREMQPLMSSL 925

  Fly  1095 SSQPPNAP-----STSIHNPRLDKRSQSISSSSLGAGAHQLGP 1132
            ...||..|     :....||.:..|| .::....||..|...|
Zfish   926 RPPPPPPPLAAQSAGKRRNPCVYLRS-LVTVPPTGAEPHSRKP 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	263/516 (51%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	220/403 (55%)
slc9a5	NP_001106943.1	b_cpa1	90..675	CDD:273294	287/594 (48%)
		Na_H_Exchanger	100..505	CDD:279355	221/404 (55%)
		NEXCaM_BD	645..>699	CDD:293250	17/54 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594236
Domainoid	1	1.000	431	1.000	Domainoid score	I564
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31247
Inparanoid	1	1.050	548	1.000	Inparanoid score	I1119
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm25967
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	O	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2680
SonicParanoid	1	1.000	-	-		X654
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.780