Protein Alignment Nhe2 and Nha2

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001247251.1
• Gene: Nha2 / 42710
• FlyBaseID: FBgn0263390
• Length: 714
• Species: Drosophila melanogaster
• Alignment Length: 732
• Identity: 137/732 - (18%)
• Similarity: 259/732 - (35%)
• Gaps: 216/732 - (29%)

  Fly     6 EQDYDSATPALAQQMNLARRACWRIKSYSSESLFKTYASVITDTSANEIDAEAPPPPR------- 63
            :||::....|....:::.|||        ||::   .||::.....:.:..:...|||
  Fly    38 QQDFERDRDANLTPLHMLRRA--------SETV---TASILEPEKEHLLGDKPQVPPRAHGSTAP 91

  Fly    64 ---DKTKTRIEP-------QIAPAKRNSSCTSSDWRGMFSKRTLLICALA----LILGSAQARPN 114
               :..::|.:|       |..|:..|::          :||     |||    :..|:|   |.
  Fly    92 SAIEAKRSRQQPNQWQLQQQQQPSSNNNN----------TKR-----ALAPGDNMTQGAA---PQ 138

  Fly   115 TSAVGVAP----------RKVSQD------------IVDAVTQLNL-------------GQSAPI 144
            .|...:.|          :|:.:|            |:...|.|||             |.|:..
  Fly   139 DSQGDILPTRPLHTKLDIQKIPEDEAGADATQNAATIILTPTSLNLTNTTTQNVAANNAGNSSTT 203

  Fly   145 DAVDVGLDPTPSARVPRPEPLKSGDENA-KGDE--GHKMERYPLSSVDFARVKTPFIIGIWILSA 206
            .:.:....|...:..|.|        || .|||  |.|...|..|.    .|.|..::.:..:..
  Fly   204 TSTNTNYGPGSVSGYPTP--------NATPGDEYKGPKWWLYIRSH----WVNTSELVALLAIFL 256

  Fly   207 SIAKIGFHMTPKLH---LIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFF----------- 257
            .:..:|:.:.|:..   .:......|.|...:.|:::.|   |.:..:....||
  Fly   257 GLWAMGWVLLPEYSQPPTVIMRIAFLFVGAQISGILVTF---VHLPDMLGMLFFGVLYANLGLAN 318

  Fly   258 ------------------FYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLY 304
                              ..:|..:.||...|  .||:|    .||.:.::.||..:|.|.|...
  Fly   319 FEGYQKFELFLREMALINIMLLAGLGLDGDAF--KRLWF----MILRLTLLPTIVEVAAIAGLAN 377

  Fly   305 ACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVF-----EEIHVNEILYIVVFGESLLNDA 364
            ....|        |.|..:.| ..:|:||.|..|:.|.     :.:.:|..::.:::..:..||.
  Fly   378 LTLSM--------PWLWGIAL-GLVITAVSPNVVVTVMLKLKEDRLGLNSGIHTLIYAMTTCNDV 433

  Fly   365 VTVVMYHMMES--YNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTG-----LVTRFTD 422
            |.:.|:.::.|  ::...|.:.:.|. ..|:|           ||:::|:|.|     |.:|...
  Fly   434 VAIFMFGVIISVIFSTTSLTQQVLQG-PIGIG-----------IGLVFGYLYGSMLQYLPSRNAT 486

  Fly   423 HVRVIEPIFIFVMAYLAYLNAEI--FHMSGIL-AITFCGITMKNY-------VESNISQKSHTTV 477
            :...:..:...:...:|.:.:.:  :..:|.| .:|...|....:       ....:..:...:|
  Fly   487 YANGLRFVLTILGGTIAVMGSRVIGYTSAGALGCVTTAFIARIGWRREETRLTPQQLQAQQIASV 551

  Fly   478 KYALKMLSSSAETIIFMFLGVATVNNM---HVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRL 539
            ...|.::....:.:.|..:|.....|:   ||  ..:..|.:...|:||:....|.:...|
  Fly   552 PKRLDLMWKFLKPVSFALIGKEINFNVLQGHV--IGYGALLVLVGSLFRLAFAYLSTYGGN---- 610

  Fly   540 HKLSRVDQFVMSYGGLRGA------------VAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFL 592
              |||.::..::..|...|            :|.|..:...|.:....|:.:.:.:|:| ||.
  Fly   611 --LSRKERAYITISGFPKATVQAALGPVALDMARAASVASPEQLALAGNLLIISVLAII-FTA-- 670

  Fly   593 QGITIKPLVKILNVKRA 609
                  ||..||.::.|
  Fly   671 ------PLGAILMLRLA 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	88/490 (18%)
		Na_H_Exchanger	199..602	CDD:279355	83/471 (18%)
Nha2	NP_001247251.1	Na_H_Exchanger	279..686	CDD:294713	84/450 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900