Protein Alignment Nhe2 and Slc9b1

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001167444.1
• Gene: Slc9b1 / 365946
• RGDID: 1305087
• Length: 519
• Species: Rattus norvegicus
• Alignment Length: 483
• Identity: 87/483 - (18%)
• Similarity: 177/483 - (36%)
• Gaps: 126/483 - (26%)

  Fly   125 VSQDIVDAVTQLNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERY------ 183
            :..|..|...|.::...||.:         |..:||:.:..|..:......|..:.||.
  Rat     6 IEVDKKDDHLQSSITDQAPEE---------PEPKVPQMKESKMKETQTTKIETEEWEREHSSTSS 61

  Fly   184 ---PLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCT- 244
               |..:|:........:|.:|||..::  ||..:.|.              |.:.|:|:.|.:
  Rat    62 FCPPQGTVNKTITDGVTLIVLWILLWAL--IGQEVLPG--------------GNLFGLVVIFYSA 110

  Fly   245 -------DVAVSPLTPNTFFFYMLPPII--LDAGYFMPN--RLF-FDNLGTILLMAVVGTIFNIA 297
                   :|...|:.|      .|||::  |.||:.:.|  .|: |.::.|....|:..|...|.
  Rat   111 FLGGKIIEVIRIPVVP------PLPPLLGMLLAGFTIRNVPILYKFVHIPTSWSSALRNTALTII 169

  Fly   298 TIGGSL-----------YACGKMGIYGESETPGLMDV------------------FLFASLISAV 333
            .|...|           ..|.::. :|    |.|::.                  ||...::.||
  Rat   170 LIRAGLGLDPQALKHLKGVCLRLS-FG----PCLLEACSAALFSHFIMNFPWQWGFLLGFVLGAV 229

  Fly   334 DPVAV---LAVFEE--IHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASG- 392
            .|..|   :.:.:|  ..|.:.:..::...|.::|.|.:.           |.:..::...:||
  Rat   230 SPAVVVPNMLLLQENGYGVEKGIPTLLVAASSMDDIVAIT-----------GFNTFLSIVFSSGS 283

  Fly   393 VGSFFVVALGGTAIGIIWGFLTGLVTRF---TDHVRVIE--PIFIFVMAYLAYLNAE---IFHMS 449
            |.|..:.:|....||::.|.:.|:..::   .|..|:.:  ...:..|...|.|..:   :....
  Rat   284 VISNILSSLRDVLIGVLVGVVMGIFVQYFPSRDQERLTQRRAFLVLSMCVSAVLGCQHIGLHGSG 348

  Fly   450 GILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSS---AETIIFMFLGV-ATVNNMHVWNTW 510
            |::.:....:..|.:.|..:..:         |:::::   .:.::|..:|. .:|.::......
  Rat   349 GLVTLVLSFMAAKRWAEEKVGVQ---------KLVANTWNIFQPLLFGLVGTEVSVESLESKTIG 404

  Fly   511 FVVLTIAFCSVFRVIGVILLSALAN-RF 537
            ..:.|:....:.|::...:|.:.|| ||
  Rat   405 MCIATLCLALLVRILATFVLMSFANFRF 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	73/410 (18%)
		Na_H_Exchanger	199..602	CDD:279355	73/400 (18%)
Slc9b1	NP_001167444.1	Na_H_Exchanger	145..496	CDD:294713	52/313 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900