Protein Alignment Nhe2 and Nhe3

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_723202.2
• Gene: Nhe3 / 33939
• FlyBaseID: FBgn0028703
• Length: 711
• Species: Drosophila melanogaster
• Alignment Length: 687
• Identity: 169/687 - (24%)
• Similarity: 282/687 - (41%)
• Gaps: 152/687 - (22%)

  Fly   171 NAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVV 235
            :||....|:::...|....|....|  ::.||:..       .|....||    |:.|.::.|::
  Fly    26 DAKATLNHRIQSLDLLVFVFLLALT--VLTIWLFK-------HHRVSWLH----ETGLAVIYGLI 77

  Fly   236 IGVVLYFC------TDVAVSP---------LTPNT------------------------------ 255
            :|.::.:.      ..:.|.|         |.|:|
  Fly    78 VGAIIRYAGTSATLVHMQVEPQGVPTYSDKLPPDTLWFRYPVNQTNGTKPPEGIKTYAYVFRGQV 142

  Fly   256 ------------------FFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGS 302
                              ||..:|||||..|||.:..:.||.|||.||..|:|||..:...|||.
  Fly   143 HDVDENEIDLKATFDPEVFFNIILPPIIFYAGYSLKKKYFFRNLGAILTFAIVGTTLSAFLIGGF 207

  Fly   303 LYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTV 367
            :|.|.|:.....|.:...:|...|.:|||..||:.:||:|.::.|:..||.:|.|||:|||||.:
  Fly   208 MYGCVKLMPKYLSSSFTFLDSLYFGALISPTDPLTILAIFNDLRVDVNLYALVLGESVLNDAVAI 272

  Fly   368 VMYHMMESYNE--IGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVR---VI 427
            |:...:::|.|  ....:.........:..||.:.|....||...|.||.|:|:|| .||   ::
  Fly   273 VLSGAIQNYGEHYSNTGEFETTAFLRSLSDFFSIFLLSLMIGAAMGCLTALMTKFT-RVRDFPLL 336

  Fly   428 EPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETII 492
            |.....:|:|..:|.||...::|::|:.||||...:|..:|:|:.|....|...::|:..||..|
  Fly   337 ESALFVLMSYSTFLLAEATELTGVVAVLFCGICQAHYTYNNLSEDSRQRTKQIFELLNFLAENFI 401

  Fly   493 FMFLGVATVN-NMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQFVMSYGGLR 556
            |.::||:... ..|.::..|::......::.|.:.|..||.|.|..|..|:|...|.::.:.|||
  Fly   402 FSYIGVSMFTFPKHHFDAGFIITAFICAAIGRAVNVYPLSWLLNIKRKPKISTNFQHMLFFAGLR 466

  Fly   557 GAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIH 621
            ||::|||.  :...|..::...:|.|..::.|||.:||.....|:..|.:.
  Fly   467 GAMSFALA--IRNTVSDERQTMLTATSLIVIFTVVIQGGAANFLLNWLKIP-------------- 515

  Fly   622 ERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLIRDLKGAEPKIIETY----------- 675
                    .|::|...:..||.|...:...||             :.|:..:.|
  Fly   516 --------VGVDDETEQLNNYQVHSVYNSMDN-------------SHPQTSDGYLQDVEGGGVNR 559

  Fly   676 SKLTMRDAMEVMRRNP--STIGQMTGTES-----------MSALFRNYTNNYIGGSPSLTNLDNT 727
            :|:.:....:.....|  .|.|.:.|...           ::.::.|:...|:  .|.||:...|
  Fly   560 NKMRLSGGTDTNLDTPVDGTNGSLGGASGGRRRNSHEKAILARIWGNFDTKYM--KPLLTHSRPT 622

  Fly   728 CSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRR 764
            ....|.:.   .||..:.||..:   .|.::...:||
  Fly   623 LLETLPVC---CNPIARLLTTTQ---QLTQDGSEFRR 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	151/607 (25%)
		Na_H_Exchanger	199..602	CDD:279355	134/471 (28%)
Nhe3	NP_723202.2	b_cpa1	155..>531	CDD:273294	125/400 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468117
Domainoid	1	1.000	89	1.000	Domainoid score	I412
eggNOG	1	0.900	-	-		E1_COG0025
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	1	1.000	-	-		otm51371
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10110
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.840