Protein Alignment Nhe2 and Slc9a6

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_038956424.1
• Gene: Slc9a6 / 302863
• RGDID: 1563582
• Length: 732
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 189/691 - (27%)
• Similarity: 301/691 - (43%)
• Gaps: 162/691 - (23%)

  Fly   173 KGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIG 237
            :.:|.|:.:...|  :.|..:.|..|:.||:.....|:.       ||    |:.|.::.|:::|
  Rat    63 QAEESHRQDSANL--LIFILLLTLTILTIWLFKHRRARF-------LH----ETGLAMIYGLLVG 114

  Fly   238 VVLYF--------------CTDVAVSPLT------------------------------------ 252
            :||.:              | :|..||.|
  Rat   115 LVLRYGIHVPSDVNNVTLSC-EVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVT 178

  Fly   253 --PNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYAC-GKMGIYGE 314
              |..||..:|||||..|||.:..|.||.|||:||..|.:||..:...||..:|.| ..|.:.|
  Rat   179 FDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTG- 242

  Fly   315 SETPG---LMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESY 376
             :..|   ..|..||.:::||.|||.|||:|.|:.|:..||.::||||:|||||.:|:...:.:|
  Rat   243 -QLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAY 306

  Fly   377 NEIGLDKIIAQDIAS---GVGSFFVVALGGTAIGIIWGFLTGLVTRFTD--HVRVIEPIFIFVMA 436
            ...| |.....|:.:   .:|.|..:..|..|:|...|.:|.|||:||.  ..:::|....|:|:
  Rat   307 QPAG-DNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMS 370

  Fly   437 YLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVA-- 499
            :..:|.||.:..:|::|:.|||||..:|..:|:|.:|....|...::|:..||..||.::|:.
  Rat   371 WSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLF 435

  Fly   500 TVNNMHVWNTWFVVLTIAFCSVF--RVIGVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFA 562
            |..| ||:|..|||  .||.::|  |...:..||.|.|..|..|:....|.:|.:.|||||:|||
  Rat   436 TFQN-HVFNPTFVV--GAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFA 497

  Fly   563 LVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANKRKPTMNERIHERFMD- 626
            |.  :.:.....:.|..:||:.:::|||::.|.....::..|:::...:.....:|..|..:..
  Rat   498 LA--IRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRYYARLWGYRDELRHGLYPQG 560

  Fly   627 -HLMAGIEDIVGKTG---NYNVRDKFKR---------------FDNRFIRPLLIRDLKGAEPKII 672
             |.:.|..|.||...   :..|.|..:|               ||:.:::|||..    :.|.:.
  Rat   561 AHSLFGETDRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTH----SGPPLT 621

  Fly   673 ETY---------------------------SKLTMRDAMEVMRRNPSTIG----------QMTGT 700
            .|.                           |.|.:.|....:....||:.          :..||
  Rat   622 TTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGT 686

  Fly   701 ESMSALFRNYT----NNYIGGS----------PSLTNLDNT 727
            .:..||.|..|    ...|.|:          |:|.:||:|
  Rat   687 STEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDT 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	175/636 (28%)
		Na_H_Exchanger	199..602	CDD:279355	147/467 (31%)
Slc9a6	XP_038956424.1	b_cpa1	94..>540	CDD:273294	146/465 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910