Protein Alignment Nhe2 and Slc9c1

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_001008762.2
• Gene: Slc9c1 / 288117
• RGDID: 1309075
• Length: 1181
• Species: Rattus norvegicus
• Alignment Length: 691
• Identity: 126/691 - (18%)
• Similarity: 252/691 - (36%)
• Gaps: 214/691 - (30%)

  Fly   201 IWILSASIAKIGFHMTPKLHL---IFPESCLLIVVGVVIGVVLYFCTDV-----AVSPLTPNTFF 257
            |.|||. |..||..:  .:||   ..|...:|.::|....::.:..|.:     |:..:.|:.||
  Rat    39 ILILSL-ICTIGAFL--NMHLKDFPIPLPVILFLIGCCFEILSFASTQIQLYADAIQWMDPDMFF 100

  Fly   258 FYMLPPIILDAGY----FMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETP 318
            ....|.||.:..:    :|..:||:.    |||:.:.|.:.|...|...|.:..|:.:   ...|
  Rat   101 GIFTPVIIFNVAFDMDIYMLQKLFWQ----ILLITIPGFMINYTLILWYLQSVNKLSL---KTIP 158

  Fly   319 GLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYH--MMESYNEIGL 381
            .|    ||::::.:.||:...|...::.::..|..::.|||||...:::::|.  :..|:....:
  Rat   159 WL----LFSAVLISSDPMLTSASIRDLGLSRSLTNLINGESLLTSVISLIIYSAVVQISFKSKHM 219

  Fly   382 DKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLV----------TRFTDHVRVIEPIFIFVMA 436
            :..:|..:.|...|:.|.:           |:||::          |.|.|.|..|  ..||.:.
  Rat   220 NHTLAHKVMSTAWSYLVES-----------FITGILITKAIQLWMATIFGDDVNHI--TLIFSVL 271

  Fly   437 YLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALK--------MLSSSAETIIF 493
            ||.:...|:..||||..:...|:.:.:           |:.|..::        .||.....::|
  Rat   272 YLIFYVCELIGMSGIFTLATIGLFLNS-----------TSFKPGVEAFLLEFWNCLSFIGFLMVF 325

  Fly   494 MFLGVATVNNMHVW----------NTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQF 548
            .|:|:....:.:::          |.:|.::      |.|::..:|:|.:.:|.. |..|....|
  Rat   326 TFIGLLIPAHTYLYISFSDVYYSLNIYFTLI------VLRLLVFLLMSPILSRLG-HGFSWRWAF 383

  Fly   549 VMSYGGLRGAVAFALVLLVDENVV-----KQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKR 608
            :|.:..::|.....:.||:..:.|     ::::..:...::|...|:.:
  Rat   384 IMVWSEMKGTPNINMALLLAYSDVSLGSERERSQILFHGVSVCVITLIV---------------- 432

  Fly   609 ANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRFIRPLLI-----RDLKGAE 668
                                                        ||||.|:.:     ||:...:
  Rat   433 --------------------------------------------NRFILPMAVIKLGLRDVTSTK 453

  Fly   669 PKII----ETYSKLTMRDAM------------------EVMRRNPSTIGQMTGTESMSALFRNYT 711
            .|.:    :.:.:||...||                  .::.:||..:.|...||.......:
  Rat   454 YKSVYYTFQHFQELTKSTAMALKFDKDLANADWNMVDKAIILQNPYALNQEETTEHQKVKCPD-- 516

  Fly   712 NNYIGGSPSLTNLDNTCSRNLDMAELDYNPSKKDLTDARIHHLLAEELKPYRRHRRLSYSRHAVD 776
                            |::.:|..   .|....:|.:.|   ||:.::..|:|..|
  Rat   517 ----------------CNKEIDET---LNIEAMELANRR---LLSAQIASYQRQYR--------- 550

  Fly   777 DRDLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASN-KEAKE 816
             .::.:|...::.:.....|.::|....|.....| .|:|:
  Rat   551 -NEILSQSAMQVLVGAAGSFGEKKGEYMSPENIKNYSESKK 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	109/576 (19%)
		Na_H_Exchanger	199..602	CDD:279355	92/447 (21%)
Slc9c1	NP_001008762.2	Na_H_Exchanger	35..457	CDD:294713	100/522 (19%)
		Crp	890..1077	CDD:223736
		CAP_ED	893..1020	CDD:237999

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840