Protein Alignment Nhe2 and SLC9C2

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_011507728.1
• Gene: SLC9C2 / 284525
• HGNCID: 28664
• Length: 1129
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 92/452 - (20%)
• Similarity: 184/452 - (40%)
• Gaps: 79/452 - (17%)

  Fly   225 ESCLLIVV------GVVIGVVLYFCTDV--AVSPLTPNTFF---FYMLPPII----LDAGYFMPN 274
            ::|.:||:      |.|||.:.|...:|  .|.||...:.|   .|..|.||    ||..::...
Human    50 KNCEVIVLTILSLSGFVIGHMAYNSVEVHQIVYPLLRTSSFSLYSYFSPLIIFMVALDVEFYTLK 114

  Fly   275 RLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVL 339
            ::|:.    :||..::.  |:.|:|     ..|.:.|....::..|....||:..:..:||:..:
Human   115 KMFWQ----VLLTGLIS--FSTASI-----IIGYVVIKFNKDSWDLQSCLLFSITLGIIDPLRSV 168

  Fly   340 AVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGT 404
            ...:.|.:::|...::.||||:..::..:.:..... |.|...  |.:|:..|:...:.: ||..
Human   169 NSLKTIGISKIYIDLIRGESLIICSIASIFFGNFRG-NRIHFS--IFRDLHVGIELSYDI-LGSI 229

  Fly   405 AIG-----IIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNY 464
            ..|     ||...|..:.:....::     |..|.|.|:.:...|...|||.||:...|:.:.:.
Human   230 IFGYWCAKIIQCILADVFSNMLTNI-----ILCFSMVYMTFYIVEFLGMSGTLALAAVGLNLDSL 289

  Fly   465 VESNISQKSHTTVKYALKMLSSSAETIIFMFLGV----ATVNNMHVWNTWFVVLTIAFCSVFRVI 525
               ....|....:...|::.||..|.:|:.|.|:    ..:::.......|:.:.....::.|::
Human   290 ---TFKPKIELVITKFLRIFSSVYEHLIYAFFGIVIGCGELSHYEFHTIPFIFILFTTVNLVRLL 351

  Fly   526 GVILLSALANRFRLHKLSRVD---QFVMSYGGLRGAVAFALVLLVD-----ENVVKQKNMFVTTT 582
            .::|:|.:.    :|.....:   ..|:::.|::|  .|.|:...|     |..|:...||:...
Human   352 TILLVSPIL----MHSNYEYNWRWGVVITWSGIKG--VFNLLWAPDVYNLAERKVEVPQMFILYV 410

  Fly   583 IAVIYFTVFLQGITIKPLVK-----ILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKT 639
            ..:...|:.:....:....:     :|::.|         :.|.:....|    |::||..|
Human   411 QVISLLTMGINSYVMTQSARKLDLCVLSLPR---------QMILQNATQH----IQEIVQNT 459

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	92/452 (20%)
		Na_H_Exchanger	199..602	CDD:279355	84/408 (21%)
SLC9C2	XP_011507728.1	Na_H_Exchanger	98..380	CDD:294713	60/308 (19%)
		Ion_trans	638..>731	CDD:278921
		CAP_ED	873..980	CDD:237999

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158309
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840