DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and SPAC15A10.06

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_594293.2	Gene:	SPAC15A10.06 / 2542747	PomBaseID:	SPAC15A10.06	Length:	567	Species:	Schizosaccharomyces pombe

Alignment Length:	580	Identity:	152/580 - (26%)
Similarity:	267/580 - (46%)	Gaps:	106/580 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 DENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTPKLHLIFPESCLLIVVG 233
            |::..|.:....|.|...::        ||:.:.::.|.:.  .:::..|......|:.:.:.||
pombe    16 DDDDDGQDPALQELYSSWAL--------FILLVLLIGALLT--SYYVQSKKIRAIHETVISVFVG 70

  Fly   234 VVIGVVLYFCTDVAVSPLTP--NTFFF-YMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFN 295
            :|:|:::.....:.:..:..  :|:|| .:||||||::||.:....||.|:||||..|..||..:
pombe    71 MVVGLIIRVSPGLIIQNMVSFHSTYFFNVLLPPIILNSGYELHQSNFFRNIGTILTFAFAGTFIS 135

  Fly   296 IATIGGSLYACGKMGIYGESETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESL 360
            ..|:|..:|....:.....|.|  .::.....:.:||.|||.|||:|....|::.||.::||||:
pombe   136 AVTLGVLVYIFSFLNFENLSMT--FVEALSMGATLSATDPVTVLAIFNSYKVDQKLYTIIFGESI 198

  Fly   361 LNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGSFFVVALGGTAIGIIWGFLTGLVTRFTDHVR 425
            |||||.:||:..::.:....|...   .:.||:|.|.:.......||:..|.:|.|:.::: ::|
pombe   199 LNDAVAIVMFETLQQFQGKTLHFF---TLFSGIGIFIITFFISLLIGVSIGLITALLLKYS-YLR 259

  Fly   426 ---VIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKMLSSS 487
               .||...|.:|||.:|..:...||||::::.|||||:|:|...|:|.|:..:.||..::|:..
pombe   260 RYPSIESCIILLMAYTSYFFSNGCHMSGVVSLLFCGITLKHYAFFNMSYKAKLSTKYVFRVLAQL 324

  Fly   488 AETIIFMFLGVATVNNMH-VWNTWFVVLTIAFCSVFRVIGVILLSALANRF-RLHKLSRVD---- 546
            :|..||::||::....:. |:...|:::|....:..|.:.|..||.|.|:| |....:.:|
pombe   325 SENFIFIYLGMSLFTQVDLVYKPIFILITTVAVTASRYMNVFPLSNLLNKFHRQRNGNLIDHIPY 389

  Fly   547 --QFVMSYGGLRGAVAFALVL-LVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKR 608
              |.::.:.||||||..||.. ...||....:    .||:.|:..|:.:.|.|...:::||:::.
pombe   390 SYQMMLFWAGLRGAVGVALAAGFEGENAQTLR----ATTLVVVVLTLIIFGGTTARMLEILHIET 450

  Fly   609 A----------------------------------------------------NKRKPTMNERIH 621
            .                                                    ....||:::::.
pombe   451 GVAADVDSDTEIGMLPWQQSPEFDLENSAMELSDASAEPVVVDQQFTTEHFDEGNIAPTLSKKVS 515

  Fly   622 ERFMDHLMAGIEDIVGKTGNYN-----VRDK----FKRFDNRFIRPLLI-RD-LKGAEPK 670
            ..|..:..|        .|.:|     .||.    ..|||...|:|:|: || ||....|
pombe   516 STFEQYQRA--------AGAFNQFFHSSRDDQAQWLTRFDEEVIKPVLLERDNLKNGTKK 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	148/560 (26%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	125/417 (30%)
SPAC15A10.06	NP_594293.2	NhaP	28..469	CDD:223104	131/460 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810