DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nhe2 and Slc9a2

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_001106806.1	Gene:	Slc9a2 / 24783	RGDID:	3719	Length:	813	Species:	Rattus norvegicus

Alignment Length:	920	Identity:	346/920 - (37%)
Similarity:	489/920 - (53%)	Gaps:	178/920 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIG 200
            |:|..:.|..|:...|...|.||.....|.......|.|....:..|.|:.::|:..|:.||.|.
  Rat    22 LSLQVAVPAGALAETLLDAPGARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEIT 86

  Fly   201 IWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPII 265
            :|||.||:||||||:..||..|.|||||||:||:::|.:::...:.:...:..:.||.|:||||:
  Rat    87 LWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIV 151

  Fly   266 LDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLI 330
            ||||||||.|.||:|||||...|||||::|...||.||:...::..:|.|:.. |:...||.|||
  Rat   152 LDAGYFMPTRPFFENLGTIFWYAVVGTLWNSIGIGLSLFGICQIEAFGLSDIT-LLQNLLFGSLI 215

  Fly   331 SAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGS 395
            |||||||||||||.|||||.|||:||||||||||||||:|::.:|:.:  :..|...|:.:|:.:
  Rat   216 SAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ--MKTIQTVDVFAGIAN 278

  Fly   396 FFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGIT 460
            ||||.:||..|||:.||:....||||.::|||||:|:|:.:||:|:.||:||:|||:|||.|.:|
  Rat   279 FFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMT 343

  Fly   461 MKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVI 525
            |..|||.|:||||:||:||.:|||||.:||:||:|:||:||...|.||..||..|:|||.::|.:
  Rat   344 MNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRAL 408

  Fly   526 GVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTV 590
            ||.:|:.:.|.||...|:..|||:::|||||||:.||||.|:...|..:|.:|:|..|.||:|||
  Rat   409 GVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTV 473

  Fly   591 FLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRF 655
            |:.||||:|||:.|:|||:||::..::|.||.||.||:..||||:.|..|:...|||||:||:::
  Rat   474 FILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKY 538

  Fly   656 IRPLLIRDLKGAEPK--IIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGS 718
            :|.||||:   .:||  |:..|.||.::.|:|           |..|..:|.:
  Rat   539 LRKLLIRE---NQPKSSIVSLYKKLEIKHAIE-----------MAETGMISTV------------ 577

  Fly   719 PSLTNLDNTCS----RNLDMAELDYNPSKKDLTDARIHHLLAEELKPYR-RHRRLSYSRHAVDDR 778
            ||..:| |.|.    |.|...|:|           .|..:|:..|  |: |.|.|||:||
  Rat   578 PSFASL-NDCREEKIRKLTPGEMD-----------EIREILSRNL--YQIRQRTLSYNRH----- 623

  Fly   779 DLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTES 843
            :|:..                         .|.::|||.:.:.
  Rat   624 NLTAD-------------------------TSERQAKEILIRR---------------------- 641

  Fly   844 SSNHSRKKSYRKRHTHNSLNKYRR--------------LEIAEECQQNPNEINVVGPSDDWD-DG 893
              .||.::|.||   .||||:.||              .::.|:.|:.....|..|.|.|.| ||
  Rat   642 --RHSLRESLRK---DNSLNRERRASTSTSRYLSLPKNTKLPEKLQKKNKVSNADGNSSDSDMDG 701

  Fly   894 LT---------------FTAKSSPDSDRANNNSLIAHIQNLPGFDASKARIVVQHYAPKADDNPD 943
            .|               |:.|:||.......|.:          |...||.            |.
  Rat   702 TTVLNLQPRARRFLPDQFSKKASPAYKMEWKNEV----------DVGSARA------------PP 744

  Fly   944 TDIESPEQAIGPTAAELILPWRRDRSYQSIVAEHPIPEEDRNLSRESDGERRVATPTATESQL-- 1006
            :...:|....|.|....:|             ..|:..:|:...|..:.......|.....:|
  Rat   745 SVTPAPRSKEGGTQTPGVL-------------RQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVR 796

  Fly  1007 ----PWKRQG 1012
                |..|:|
  Rat   797 RASEPGNRKG 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	265/516 (51%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	219/402 (54%)
Slc9a2	NP_001106806.1	b_cpa1	75..631	CDD:273294	287/628 (46%)
		Na_H_Exchanger	85..485	CDD:279355	219/402 (54%)
		NEXCaM_BD	579..685	CDD:293250	37/176 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	649..709		18/62 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..813		16/96 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352304
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	LDO	PTHR10110
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740