DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and Slc9a7

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_796327.1	Gene:	Slc9a7 / 236727	MGIID:	2444530	Length:	726	Species:	Mus musculus

Alignment Length:	756	Identity:	203/756 - (26%)
Similarity:	332/756 - (43%)	Gaps:	169/756 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 WRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLD 152
            :||: |.|.||:..|.::||.. .|...:|...|..:.|..:.:..|:
Mouse    15 FRGL-SPRLLLLPLLPVLLGRG-LRAGAAASSGAAAEDSSAMEELATE----------------- 60

  Fly   153 PTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTP 217
                               .:.:|.|:.:  .:|.:.|..:.|..|:.||:...  .::.|
Mouse    61 -------------------KEAEESHRQD--SVSLLTFILLLTLTILTIWLFKH--RRVRF---- 98

  Fly   218 KLHLIFPESCLLIVVGVVIGVVLYF-------------CT--DVAVSPL---------------- 251
             ||    |:.|.::.|:::||:|.:             ||  |.|.|.|
Mouse    99 -LH----ETGLAMIYGLIVGVILRYGTPATSGHDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGE 158

  Fly   252 --------------------TPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNI 296
                                .|..||..:|||||..|||.:..|.||.|||:||..|.:||..:.
Mouse   159 ISPGKINNVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSC 223

  Fly   297 ATIGGSLYACGK-MGIYGE-SETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGES 359
            ..||..:|...| |.|.|: |:.....|...|.::|||.|||.|||:|.|:|.:..||.::||||
Mouse   224 FIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGES 288

  Fly   360 LLNDAVTVVMYHMMESYNEIGLDKIIAQDIAS---GVGSFFVVALGGTAIGIIWGFLTGLVTRFT 421
            :|||||.:|:...:.:|...||: ..|.|.|:   .||.|..:..|...:|.:.|.:|.|||:||
Mouse   289 VLNDAVAIVLSSSIVAYQPAGLN-THAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFT 352

  Fly   422 D-H-VRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKML 484
            . | ..::|....|:|::..:|.||....:|::|:.|||||..:|..:|:|.:|.:..|...::|
Mouse   353 KLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEVL 417

  Fly   485 SSSAETIIFMFLGVATVN-NMHVWNTWFVVLTIAFCSVF--RVIGVILLSALANRFRLHKLSRVD 546
            ...||..||.::|:|... ..||::..|::  .||.::|  |...:..||...|..|.||:....
Mouse   418 HFLAENFIFSYMGLALFTFQKHVFSPIFII--GAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF 480

  Fly   547 QFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANK 611
            |.:|.:.|||||:||||.:....:..:|  |..|||:.:::|||::.|....|::..||::...:
Mouse   481 QHMMMFSGLRGAMAFALAIRDTASYARQ--MMFTTTLLIVFFTVWVIGGGTTPMLSWLNIRVGVE 543

  Fly   612 RKPTMNERIHERFMDHLMAGIE-----------------DIVGKTGNYNVRDK----FKR---FD 652
            .  ...|..:|....:...|::                 |.:...|....:.:    |:.   ||
Mouse   544 E--LSEEDQNENRWQYFRVGVDPDQDPPPNNDSFQVLQGDGMDSVGGSRTKQESAWIFRLWYIFD 606

  Fly   653 NRFIRPLLIRDLKGAEPKIIET---YSKLTMR--------DAMEVMRRNPS----TIGQMTGTES 702
            :.:::|:|..    :.|.:..|   :..|..|        |..|.:|.:.|    |.|.:|.|..
Mouse   607 HNYLKPILTH----SGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREDDSDFILTEGDLTLTYG 667

  Fly   703 MSALFRNYTNNYIGGSPSL-------TNLDNTCSRNLDMAE 736
            .|.:..|.:::....|.||       ::.:....|:|.|.:
Mouse   668 DSTVTANGSSSSYTASTSLECGRRTKSSSEEVLERDLGMGD 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	178/614 (29%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	151/463 (33%)
Slc9a7	NP_796327.1	b_cpa1	93..>552	CDD:273294	152/476 (32%)
Slc9a7	NP_796327.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	675..726		6/34 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810