Protein Alignment Nhe2 and Slc9a7

DIOPT Version :10

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: NP_796327.1
• Gene: Slc9a7 / 236727
• MGIID: 2444530
• Length: 726
• Species: Mus musculus
• Alignment Length: 756
• Identity: 203/756 - (26%)
• Similarity: 332/756 - (43%)
• Gaps: 169/756 - (22%)

  Fly    88 WRGMFSKRTLLICALALILGSAQARPNTSAVGVAPRKVSQDIVDAVTQLNLGQSAPIDAVDVGLD 152
            :||: |.|.||:..|.::||.. .|...:|...|..:.|..:.:..|:
Mouse    15 FRGL-SPRLLLLPLLPVLLGRG-LRAGAAASSGAAAEDSSAMEELATE----------------- 60

  Fly   153 PTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTP 217
                               .:.:|.|:.:  .:|.:.|..:.|..|:.||:...  .::.|
Mouse    61 -------------------KEAEESHRQD--SVSLLTFILLLTLTILTIWLFKH--RRVRF---- 98

  Fly   218 KLHLIFPESCLLIVVGVVIGVVLYF-------------CT--DVAVSPL---------------- 251
             ||    |:.|.::.|:::||:|.:             ||  |.|.|.|
Mouse    99 -LH----ETGLAMIYGLIVGVILRYGTPATSGHDKSLSCTQEDRAFSTLLVNVSGKFFEYTLKGE 158

  Fly   252 --------------------TPNTFFFYMLPPIILDAGYFMPNRLFFDNLGTILLMAVVGTIFNI 296
                                .|..||..:|||||..|||.:..|.||.|||:||..|.:||..:.
Mouse   159 ISPGKINNVEQNDMLRKVTFDPEVFFNILLPPIIFHAGYSLKKRHFFRNLGSILAYAFLGTAVSC 223

  Fly   297 ATIGGSLYACGK-MGIYGE-SETPGLMDVFLFASLISAVDPVAVLAVFEEIHVNEILYIVVFGES 359
            ..||..:|...| |.|.|: |:.....|...|.::|||.|||.|||:|.|:|.:..||.::||||
Mouse   224 FIIGNLMYGVVKLMKIVGQLSDKFYYTDCLFFGAIISATDPVTVLAIFNELHADVDLYALLFGES 288

  Fly   360 LLNDAVTVVMYHMMESYNEIGLDKIIAQDIAS---GVGSFFVVALGGTAIGIIWGFLTGLVTRFT 421
            :|||||.:|:...:.:|...||: ..|.|.|:   .||.|..:..|...:|.:.|.:|.|||:||
Mouse   289 VLNDAVAIVLSSSIVAYQPAGLN-THAFDAAAFFKSVGIFLGIFSGSFTMGAVTGVVTALVTKFT 352

  Fly   422 D-H-VRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKML 484
            . | ..::|....|:|::..:|.||....:|::|:.|||||..:|..:|:|.:|.:..|...::|
Mouse   353 KLHCFPLLETALFFLMSWSTFLLAEACGFTGVVAVLFCGITQAHYTYNNLSVESRSRSKQLFEVL 417

  Fly   485 SSSAETIIFMFLGVATVN-NMHVWNTWFVVLTIAFCSVF--RVIGVILLSALANRFRLHKLSRVD 546
            ...||..||.::|:|... ..||::..|::  .||.::|  |...:..||...|..|.||:....
Mouse   418 HFLAENFIFSYMGLALFTFQKHVFSPIFII--GAFVAIFLGRAAHIYPLSFFLNLGRRHKIGWNF 480

  Fly   547 QFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVKRANK 611
            |.:|.:.|||||:||||.:....:..:|  |..|||:.:::|||::.|....|::..||::...:
Mouse   481 QHMMMFSGLRGAMAFALAIRDTASYARQ--MMFTTTLLIVFFTVWVIGGGTTPMLSWLNIRVGVE 543

  Fly   612 RKPTMNERIHERFMDHLMAGIE-----------------DIVGKTGNYNVRDK----FKR---FD 652
            .  ...|..:|....:...|::                 |.:...|....:.:    |:.   ||
Mouse   544 E--LSEEDQNENRWQYFRVGVDPDQDPPPNNDSFQVLQGDGMDSVGGSRTKQESAWIFRLWYIFD 606

  Fly   653 NRFIRPLLIRDLKGAEPKIIET---YSKLTMR--------DAMEVMRRNPS----TIGQMTGTES 702
            :.:::|:|..    :.|.:..|   :..|..|        |..|.:|.:.|    |.|.:|.|..
Mouse   607 HNYLKPILTH----SGPPLTTTLPAWCGLLARCLTSPQVYDNQEPLREDDSDFILTEGDLTLTYG 667

  Fly   703 MSALFRNYTNNYIGGSPSL-------TNLDNTCSRNLDMAE 736
            .|.:..|.:::....|.||       ::.:....|:|.|.:
Mouse   668 DSTVTANGSSSSYTASTSLECGRRTKSSSEEVLERDLGMGD 708

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	Na_H_Exchanger	189..704	CDD:470090	178/614 (29%)
Slc9a7	NP_796327.1	Na_H_Exchanger	93..>552	CDD:470090	152/476 (32%)
		Required for trans-Golgi network localization. /evidence=ECO:0000250|UniProtKB:Q96T83	534..560		4/27 (15%)
		Required for trans-Golgi network localization. /evidence=ECO:0000250|UniProtKB:Q96T83	564..569		0/4 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..726		6/34 (18%)