Protein Alignment Nhe2 and SLC9A8

DIOPT Version :9

• Sequence 1: NP_001137851.1
• Gene: Nhe2 / 35376
• FlyBaseID: FBgn0040297
• Length: 1322
• Species: Drosophila melanogaster
• Sequence 2: XP_011527038.1
• Gene: SLC9A8 / 23315
• HGNCID: 20728
• Length: 630
• Species: Homo sapiens
• Alignment Length: 610
• Identity: 167/610 - (27%)
• Similarity: 285/610 - (46%)
• Gaps: 95/610 - (15%)

  Fly   153 PTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIGIWILSASIAKIGFHMTP 217
            |||...:   .|:::|::..:.::...|               .....:.:|:..|..:...:..
Human    36 PTPGKPI---LPVQTGEQAQQEEQSSGM---------------TIFFSLLVLAICIILVHLLIRY 82

  Fly   218 KLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLT---------PNTFFFYMLPPIILDAGYFMP 273
            :||.: |||..::.:|:::|.|:..   :....|.         ||.||..:|||||.::||.:.
Human    83 RLHFL-PESVAVVSLGILMGAVIKI---IEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLH 143

  Fly   274 NRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIY--------------GESETPGLMDVF 324
            ...||.|:|:|.|.||.||..:...:||.:|..|: |.:              .......:.|.|
Human   144 KGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQ-GFFFVCVCVFVCFILQADVISKLNMTDSF 207

  Fly   325 LFASLISAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESY------------- 376
            .|.||||||||||.:|:|..:||:.:|.::|||||:|||||::|:.:..|.|
Human   208 AFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTEEKYAPGSCCHLSLVIR 272

  Fly   377 -----NEI----------GLDKIIAQDIA------SGVGSFFVVALGGTAIGIIWGFLTGLVTRF 420
                 .|:          ||.:....|::      ..:..|..:..|..|:|.:.|.::.||.:.
Human   273 IIPGFEEVYFINDHLQTEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKH 337

  Fly   421 TDHVRV--IEPIFIFVMAYLAYLNAEIFHMSGILAITFCGITMKNYVESNISQKSHTTVKYALKM 483
            .|..:.  :|...:.:.|||.|..||...:|||:||.|.||.|.:|...|:|..:...::..|:.
Human   338 IDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRT 402

  Fly   484 LSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVIGVILLSALANRFRLHKLSRVDQF 548
            ::...||.:|.|||::..:..|.:...||:..|......|.:.:..||.|.|.||.||::....|
Human   403 VAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMF 467

  Fly   549 VMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTVFLQGITIKPLVKILNVK--RANK 611
            :|.:.|||||:.:||.|.:|...::::.:..||||.::.||:.|.|.:..||:::::::  :|::
Human   468 IMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHR 532

  Fly   612 R-KPTMNERIHERF-----MDHLMAGIEDIVGKTGNYNVRDKFKRF---DNRFIRPLLIRDLKGA 667
            | |..:|....|:.     .:||....|:  ....:|..|...|.|   |.:::.|...|.|...
Human   533 RNKKDVNLSKTEKMGNTVESEHLSELTEE--EYEAHYIRRQDLKGFVWLDAKYLNPFFTRRLTQE 595

  Fly   668 EPKIIETYSKLTMRDAMEVMRRNPS 692
            :........|.......|.:|:.||
Human   596 DLHHGRIQMKTLTNKWYEEVRQGPS 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	161/574 (28%)
		Na_H_Exchanger	199..602	CDD:279355	140/461 (30%)
SLC9A8	XP_011527038.1	NhaP	60..533	CDD:223104	142/492 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810