DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nhe2 and Slc9a2

DIOPT Version :9

Sequence 1:	NP_001137851.1	Gene:	Nhe2 / 35376	FlyBaseID:	FBgn0040297	Length:	1322	Species:	Drosophila melanogaster
Sequence 2:	NP_001028461.2	Gene:	Slc9a2 / 226999	MGIID:	105075	Length:	814	Species:	Mus musculus

Alignment Length:	891	Identity:	341/891 - (38%)
Similarity:	495/891 - (55%)	Gaps:	119/891 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 LNLGQSAPIDAVDVGLDPTPSARVPRPEPLKSGDENAKGDEGHKMERYPLSSVDFARVKTPFIIG 200
            |:|..:.|..|:...|...|.||.....|.......|.|....:..|.|:.::|:..|:.||.|.
Mouse    22 LSLQVAVPAGALAETLLDAPRARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEIT 86

  Fly   201 IWILSASIAKIGFHMTPKLHLIFPESCLLIVVGVVIGVVLYFCTDVAVSPLTPNTFFFYMLPPII 265
            :|||.||:||||||:..||..|.|||||||:||:::|.:::...:.:...:..:.||.|:||||:
Mouse    87 LWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIV 151

  Fly   266 LDAGYFMPNRLFFDNLGTILLMAVVGTIFNIATIGGSLYACGKMGIYGESETPGLMDVFLFASLI 330
            ||||||||.|.||:|.|||...|||||::|...||.||:...::..:|.|:.. |:...||.|||
Mouse   152 LDAGYFMPTRPFFENFGTIFWYAVVGTLWNSIGIGVSLFGICQIEAFGLSDIT-LLQNLLFGSLI 215

  Fly   331 SAVDPVAVLAVFEEIHVNEILYIVVFGESLLNDAVTVVMYHMMESYNEIGLDKIIAQDIASGVGS 395
            |||||||||||||.|||||.|||:||||||||||||||:|::.:|:.:  :..|...|:.:|:.:
Mouse   216 SAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQ--MKTIQTVDVFAGIAN 278

  Fly   396 FFVVALGGTAIGIIWGFLTGLVTRFTDHVRVIEPIFIFVMAYLAYLNAEIFHMSGILAITFCGIT 460
            ||||.:||..|||:.||:....||||.::|||||:|:|:.:||:|:.||:||:|||:|||.|.:|
Mouse   279 FFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMT 343

  Fly   461 MKNYVESNISQKSHTTVKYALKMLSSSAETIIFMFLGVATVNNMHVWNTWFVVLTIAFCSVFRVI 525
            |..|||.|:||||:||:||.:|||||.:||:||:|:||:||...|.||..||..|:|||.::|.:
Mouse   344 MNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRAL 408

  Fly   526 GVILLSALANRFRLHKLSRVDQFVMSYGGLRGAVAFALVLLVDENVVKQKNMFVTTTIAVIYFTV 590
            ||.:|:.:.|.||...|:..|||:::|||||||:.||||.|:...|..:|.:|:|..|.||:|||
Mouse   409 GVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTV 473

  Fly   591 FLQGITIKPLVKILNVKRANKRKPTMNERIHERFMDHLMAGIEDIVGKTGNYNVRDKFKRFDNRF 655
            |:.||||:|||:.|:|||:||::..::|.||.||.||:..||||:.|..|:...|||||:||:::
Mouse   474 FILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKY 538

  Fly   656 IRPLLIRDLKGAEPK--IIETYSKLTMRDAMEVMRRNPSTIGQMTGTESMSALFRNYTNNYIGGS 718
            :|.||||:   .:||  |:..|.||.::.|:|           |..|..:|.:
Mouse   539 LRKLLIRE---NQPKSSIVSLYKKLEIKHAIE-----------MAETGMISTV------------ 577

  Fly   719 PSLTNLDNTCS----RNLDMAELDYNPSKKDLTDARIHHLLAEELKPYR-RHRRLSYSRHAVDDR 778
            ||..:| |.|.    |.|...|:|           .|..:|:..|  |: |.|.|||:||
Mouse   578 PSFASL-NDCREEKIRKLTPGEMD-----------EIREILSRNL--YQIRQRTLSYNRH----- 623

  Fly   779 DLSTQVNYKMQMNFRRMFNDRKHHKRSKRGASNKEAKENVKQNHVSFHDFQQNGTTKQLTNGTES 843
            :|:..                         .|.::|||.:.:...|..:..:.          ::
Mouse   624 NLTAD-------------------------TSERQAKEILIRRRHSLRESLRK----------DN 653

  Fly   844 SSNHSRKKSYRKRHTHNSLNKYRRLEIAEECQQNPNEINVVGPSDDWDDGLTFTAKSSPDSDRAN 908
            |||..|:.|   ..|...|:..:..::.|:.|:.....|..|.|.|.|..:..|..:.....|
Mouse   654 SSNRERRAS---TSTSRYLSLPKNTKLPEKLQKKKKVSNADGNSSDSDPDVGTTVLNLQPRTR-- 713

  Fly   909 NNSLIAHIQNLPGFDASKARIVVQHYAPKADDNPDTDIESPEQAIGPTAAELILPWRRDRSYQSI 973
                    :.||...:.||.   |.|  |.:...:.|:.|..  :.|:.:.  .|..:|...|:.
Mouse   714 --------RFLPDQFSKKAS---QAY--KMEWKNEVDVGSVR--VPPSVSP--APRSKDGGTQTP 761

  Fly   974 -VAEHPIPEEDRNLSRESDGERRVATPTATESQL------PWKRQG 1012
             :...|:..:|:...|..:.......|.....:|      |..|:|
Mouse   762 GLLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKG 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nhe2	NP_001137851.1	b_cpa1	189..704	CDD:273294	264/516 (51%)
Nhe2	NP_001137851.1	Na_H_Exchanger	199..602	CDD:279355	218/402 (54%)
Slc9a2	NP_001028461.2	b_cpa1	75..631	CDD:273294	286/628 (46%)
		Na_H_Exchanger	85..485	CDD:279355	218/402 (54%)
		NEXCaM_BD	579..685	CDD:293250	34/162 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0025
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000129
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101278
Panther	1	1.100	-	-	LDO	PTHR10110
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2680
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.770